Education & Training
- Postdoctoral Research Associate: Washington University, St. louis, MO, USA, 2023
- PhD in Computational systems biology: University of Luxembourg, Luxembourg., 2019
- MSc in Bioinformatics: Saarland University, Germany, 2014
- MS in Bioinformatics: Government College University, Faisalabad, Pakistan, 2012
- BS(H) in Bioinformatics: Government College University, Faisalabad, Pakistan, 2010
Major Awards
- EURON Mobility Grant, 2019
- Joint Programme – Neurodegenerative Disease (JPND) Doctoral Fellowship, 2015
Research Interests
My research interests lie in the intersection of Bioinformatics and computational systems biology. Currently, I am working on the integrative machine learning analysis of proteomics data from disease-related case-control studies, focusing on biomarker development for the neurodegenerative disorders e.g. Alzheimer’s and Parkinson’s disease.
Key Publications
- Ali M, Archer DB, … , Cruchaga C, (2023 Apr). Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease. Acta Neuropathol Commun. 11(1): 68. https://doi.org/10.1186/s40478-023-01563-4
Read publication »Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease. - Ali M, Sung YJ, … , Cruchaga C, (2022 May). Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk. PLoS One. 17(5): e0267298. https://doi.org/10.1371/journal.pone.0267298
Read publication »Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk. - Timsina J, Ali M, … , Cruchaga C, (2024 Jan). Harmonization of CSF and imaging biomarkers for Alzheimer’s disease biomarkers: need and practical applications for genetics studies and preclinical classification. Neurobiology of Disease. https://doi.org/10.1016/j.nbd.2023.106373
Read publication »Single-Cell Transcriptional Profiling and Gene Regulatory Network Modeling in Tg2576 Mice Reveal Gender-Dependent Molecular Features Preceding Alzheimer-Like Pathologies. - Jung S, Appleton E, Ali M, … , del Sol A, (2021 Mar). A computer-guided design tool to increase the efficiency of cellular conversions. Nat Commun 12, 1659. https://doi.org/10.1038/s41467-021-21801-4
Read publication »Harmonization of CSF and imaging biomarkers for Alzheimer’s disease biomarkers: need and practical applications for genetics studies and preclinical classification. - Bigley TM, Xiong M, Ali M, … , Holtzman DM, (2022 Jan). Murine roseolovirus does not accelerate amyloid-ß pathology and human roseoloviruses are not over-represented in Alzheimer disease brains. Mol Neurodegener. 17(1): 10. https://doi.org/10.1186/s13024-021-00514-8
Read publication »Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains. - Ali M, Huarte OU, … , Glaab E, (2022 Aug). Single-Cell Transcriptional Profiling and Gene Regulatory Network Modeling in Tg2576 Mice Reveal Gender-Dependent Molecular Features Preceding Alzheimer-Like Pathologies. Mol Neurobiol. 61(2): 541-566. https://doi.org/10.1007/s12035-022-02985-2
Read publication »Altered sphingolipid function in Alzheimer’s disease; a gene regulatory network approach.