Carlos Cruchaga

Professor of Psychiatry

Additional Titles & Roles

  • Knight-ADRC Genetics and Hight-throughput Omics Core leader
  • DIAN (The Dominantly Inherited Alzheimer Network) Genetics Core co-leader
  • Scientific advisor McDonnell Genome Institute (MGI)
  • Director NeuroGenomics and Informatics lab

Education & Training

  • PhD: Molecular and Cell Biology: University of Navarra, Pamplona, Spain, 2005
  • BA: Biochemistry and Molecular Biology: University of Navarra, Pamplona, Spain, 2002

Research Interests

Genetic and multi-omic approaches to identify novel variants, genes and pathways implicated on neurodegeneration, with the ultimate goal of understanding the biology of neurodegenerative diseases

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Key Publications

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Funded Research Projects

NIH-funded projects:
NIA (PI):Identification and Characterization of AD Risk Pathways using Multi-dimensional “OMICS” Data

NIA (PI):The Familial Alzheimer Sequencing (FASe) Project

NIA (PI): Identifying Rare Variants that Increase Risk for Alzheimer’s Disease

NIA (PI): Using Quantitative Traits to Identify Novel Genes for Alzheimer’s Disease and Other Complex Traits

NIA (PI): Phenotypic and Genetic Analysis of Soluble TREM2 in Cerebrospinal Fluid in AD

NIA (Site-PI):The National Institute on Aging (NIA) Late Onset of Alzheimer’s Disease (LOAD) Family Based Study (FBS)

NIA (Core Leader): Alzheimer’s Disease Research Center

NIA (Core Leader): Dominantly Inherited Alzheimer Network

NIA (Core Leader):DIAN-TU: Next Generation Prevention Trial

Alzheimer’s Association (PI): Functional Chracterization of Coding Risk Variants in TREM2 and PLD3

McDonnell Center for Cellular and Molecular Neurobiology (Co-PI):Characterization of the Brain Cellular Population Structure Altered in Alzheimer’s Disease

NIA (Investigator): Defining the Mechanisms by Which MS4A Genes Regulate TREM2 in Alzheimer Disease

Chan Zuckerberg Initiative/CZI (Co-PI): Molecular Mechanisms of the Central Regulator of TREM2 Dysfunction

Michael J. Fox Foundation for Parkinson’s Research (PI) :Leveraging Multi-Omics Data to Identify Common Pathways and Biomarkers for AD and PD

Alector LLC (PI): Mendelian Randomization for Unbiased Biomarker Discovery for AD

Biogen (PI): Identifying Genetic Variants Associated with Stroke Outcomes