Anil Cashikar
Associate Professor of Psychiatry
Associate Professor of Neurology
- Phone: 314-273-1863
- Email: cashikar@nospam.wustl.edu
Additional Titles & Roles
- Associate Professor of Psychiatry
- Member, Hope Center for Neurological Disorders
- Member, Taylor Family Insititute for Innovvative Psychiatric Research
Education & Training
- Ph.D.: Jawaharlal Nehru University, New Delhi, India, 1997
- M.Sc.: Madurai Kamaraj University, Madurai, India, 1991
- B.Sc: Bangalore University, Bengaluru, India, 1989
Research Interests
Neuroinflammation is thought to play an important role in the pathogenesis of various psychiatric and neurological disorders. We are interested in understanding how cholesterol metabolism influences neuroinflammation.
Key Publications
- Wong MY, Lewis M, Doherty JJ, Shi Y, Cashikar AG, Amelianchik A, Tymchuk S, Sullivan PM, Qian M, Covey DF, Petsko GA, Holtzman DM, Paul SM, Luo W, (2020 Jun). 25-Hydroxycholesterol amplifies microglial IL-1ß production in an apoE isoform-dependent manner. J Neuroinflammation. 17(1): 192.
Read publication »25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner. - Izumi Y, Cashikar AG, Krishnan K, Paul SM, Covey DF, Mennerick SJ, Zorumski CF, (2021 Dec). A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol. J Neurosci. 41(49): 10054-10064.
Read publication »A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol. - Cashikar AG, Toral-Rios D, Timm D, Romero J, Strickland M, Long JM, Han X, Holtzman DM, Paul SM, (2023 Apr). Regulation of astrocyte lipid metabolism and ApoE secretionby the microglial oxysterol, 25-hydroxycholesterol. J Lipid Res. 64(4): 100350.
Read publication »Regulation of astrocyte lipid metabolism and ApoE secretionby the microglial oxysterol, 25-hydroxycholesterol. - Strickland MR, Rau MJ, Summers B, Basore K, Wulf J, Jiang H, Chen Y, Ulrich JD, Randolph GJ, Zhang R, Fitzpatrick JAJ, Cashikar AG, Holtzman DM, (2024 Apr). Apolipoprotein E secreted by astrocytes forms antiparallel dimers in discoidal lipoproteins. Neuron. 112(7): 1100-1109.e5.
Read publication »Apolipoprotein E secreted by astrocytes forms antiparallel dimers in discoidal lipoproteins. - Litvinchuk A, Suh JH, Guo JL, Lin K, Davis SS, Bien-Ly N, Tycksen E, Tabor GT, Remolina Serrano J, Manis M, Bao X, Lee C, Bosch M, Perez EJ, Yuede CM, Cashikar AG, Ulrich JD, Di Paolo G, Holtzman DM, (2024 Feb). Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist. Neuron. 112(3): 384-403.e8.
Read publication »Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist. - Serio TR, Cashikar AG, Kowal AS, Sawicki GJ, Moslehi JJ, Serpell L, Arnsdorf MF, Lindquist SL, (2000 Aug). Nucleated conformational conversion and the replication of conformational information by a prion determinant. Science. 289(5483): 1317-21.
Read publication »Nucleated conformational conversion and the replication of conformational information by a prion determinant.
Funded Research Projects
NIA(PI):Role of the microglial immune-oxysterol 25-hydroxycholesterol in mediating neuroinflammation and neurodegeneration in the P301S tau transgenic mouse model of Alzheimer’s disease
NIA(Co-PI):Biology and Pathobiology of apoE in aging and Alzheimer’s Disease-Parent Grant APOE effects on glial lipid metabolism and 25-hydroxycholesteral: Effects on aging and AD-related pathology-Project 2
Cure Alzheimer’s Fund(PI):Development of small molecule inhibitors of cholesterol 25-hydroxylase
BrightFocus Foundation (mentor for Postdoc fellowship): Role of an oxysterol pathway in mediating brain infiltration of lymphocytes in tau-dependent neuroinflammation and neurodegeneration