Andrey Anokhin

Andrey Anokhin

Professor of Psychiatry

Education & Training

  • PhD: Russia Academy of Sciences, Moscow, Russia, 1987
  • MS: Moscow State University, Moscow, Russia, 1981

Research Interests

My research is concerned with linking genetics, brain function, and behavior for a better understanding of the determinants and consequences of substance use disorders and related psychopathology. A major theoretical premise of this work is that a deficit in prefrontally mediated inhibitory self-regulation of behavior constitutes a core component of vulnerability to substance use disorders (SUDs) and related externalizing psychopathology. A detailed characterization of the “disinhibitory” deficit, its genetic bases, developmental trajectory, and pathways by which it leads to addictive behaviors requires an integrative, multidisciplinary approach that combines genetics, cognitive neuroscience, and behavioral assessments. Accordingly, my laboratory is conducting interdisciplinary studies using a combination of neurophysiological (EEG/ERP) methods, neuropsychological, behavioral, and self-report assessments and, more recently, structural and functional magnetic resonance imaging (fMRI). One major goal of these studies is to identify neurocognitive characteristics, or “endophenotypes”, mediating genetic risk for substance use disorders and associated psychopathology using statistical analysis of twin data and molecular genetic methods. Another major goal of our studies is to determine how the use of substances such as alcohol, tobacco, and marijuana leads to long-term changes in brain function, cognition, and behavior. To achieve this goal, we are conducting prospective longitudinal studies and analyzing data from twin pairs who are discordant for substance use.

Key Publications

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    Funded Research Projects

    NICHD(PI):Genetics, the Adolescent Brain, and Addiction Liability: A Longitudinal Twin Study

    NIDA(PI):Neurocognitive Consequences of Adolescent Marijuana Use

    NIDA(PI):Test-Retest Reliability of Putative fMRI Endophenotypes for Substance Abuse Risk

    NIAAA(Significant Contributor):Collaborative Study on the Genetics of Alcoholism (COGA)