Abhirami Kannan Iyer

Education & Training

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• • PhD: Indiana University School of Medicine, Indianapolis, IN, 2016

Major Awards

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• • George Bartzokis Travel Award, New Vision Research, 11th Annual Charleston Conferences on Alzheimer’s Disease, 2023

Hope Center for Neurological Disorders and the Washington University Institute of Clinical and Translational Sciences, Just-in-time (JIT) core usage award, 2022

Indiana University School of Medicine postdoctoral travel grant for the Society for Neuroscience meeting, 2017

Indiana University School of Medicine graduate student travel grant for the American Association of Immunologists meeting, 2014

Indiana University Simon Cancer Center Annual Cancer Research Day, Honorable Mention in Basic Science Category by Graduate Student, 2013

Junior Research Fellowship, Council of Scientific & Industrial Research, India, 2010

Research Interests

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Neurodegeneration, Neuroimmunology, microglia, astrocytes

Visit lab website

Key Publications

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• Filipello F, You SF, Mirfakhar FS, Mahali S, Bollman B, Acquarone M, Korvatska O, Marsh JA, Sivaraman A, Martinez R, Cantoni C, De Feo L, Ghezzi L, Minaya MA, Renganathan A, Cashikar AG, Satoh JI, Beatty W, Iyer AK, Cella M, Raskind WH, Piccio L, Karch CM, (2023 Jun). Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation. Acta Neuropathol. 145(6): 749-772.
  Read publication »Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation.
• Minaya MA, Mahali S, Iyer AK, Eteleeb AM, Martinez R, Huang G, Budde J, Temple S, Nana AL, Seeley WW, Spina S, Grinberg LT, Harari O, Karch CM, (2023 Feb). Conserved gene signatures shared among MAPT mutations reveal defects in calcium signaling. Front Mol Biosci. 2023 Feb 9;10:1051494. doi: 10.3389/fmolb.2023.1051494
  Read publication »Conserved gene signatures shared among MAPT mutations reveal defects in calcium signaling.
• You SF, Brase L, Filipello F, Iyer AK, Del-Aguila J, He J, D’Oliveira Albanus R, Budde J, Norton J, Gentsch J, Dräger NM, Sattler SM, Kampmann M, Piccio L, Morris JC, Perrin RJ, McDade E, , Paul SM, Cashikar AG, Benitez BA, Harari O, Karch CM, (2023 Feb). MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state. medRxiv.
  Read publication »MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state.
• Runge EM, Setter DO, Iyer AK, Regele EJ, Kennedy FM, Sanders VM, Jones KJ, (2022 Oct). Cellular Sources and Neuroprotective Roles of Interleukin-10 in the Facial Motor Nucleus after Axotomy. Cells. 11(19): 3167. doi: 10.3390/cells11193167
  Read publication »Cellular Sources and Neuroprotective Roles of Interleukin-10 in the Facial Motor Nucleus after Axotomy.
• Runge EM, Iyer AK, Setter DO, Kennedy FM, Sanders VM, Jones KJ, (2020 Apr). CD4+ T cell expression of the IL-10 receptor is necessary for facial motoneuron survival after axotomy. J Neuroinflammation. 17(1): 121.
  Read publication »CD4+ T cell expression of the IL-10 receptor is necessary for facial motoneuron survival after axotomy.
• Liu J, Gallo RM, Khan MA, Iyer AK, Kratzke IM, Brutkiewicz RR, (2019 Feb). JNK2 modulates the CD1d-dependent and -independent activation of iNKT cells. Eur J Immunol. 49(2): 255-265.
  Read publication »JNK2 modulates the CD1d-dependent and -independent activation of iNKT cells.

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