Tamara Hershey

James S. McDonnell Professor of Cognitive Neuroscience in Psychiatry & Radiology

Additional Titles & Roles

  • Director, Neuroimaging Labs Research Center (NIL-RC) @ MIR
  • Director, McDonnell Center for Systems Neuroscience
  • Vice Chair for Translational Research in Psychiatry

Education & Training

  • PhD: Clinical Psychology: Washington University, St. Louis, MO, 1996
  • BA: Psychology: Earlham College, IN, 1988

Research Interests

Neuropathophysiology underlying cognitive and mood aspects of Parkinson’s disease and other dopaminergic disorders.
Neuropathophysiological and behavioral effects of obesity and diabetes.
Using neuroimaging (MRI, fMRI and PET) and neuropsychological techniques, we study:
1) effects of severe hypoglycemia and hyperglycemia on the brain in children and adults with type 1 diabetes mellitus.
2) neurodevelopmental and neurodegenerative changes in Wolfram syndrome
3) relationship between obesity and dopamine receptors in the brain, their relationship to behavioral features and weight loss.
4) effects of Parkinson’s disease on cognitive and mood processes; how deep brain stimulation of the subthalamic nucleus affects brain function.

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Key Publications

Funded Research Projects

NICHD (PI): Tracking Neurodegeneration in Early Wolfram Syndrome
NIDDK (PI): Early Predictors of Brain Health and Development in Youth with T1DM
NINDS (PI): Using Diffuse Optical Tomography to Understand Deep Brain Stimulations Impact on Cortical Networks
NINDS (Co-PI): NINDS Center Core for Brain Imaging
NINDS (Key Personnel): Glucose Metabolism and the Default Mode Network in Health and Disease
NIEHS (Key Personnel): Motor and Cognitive Health Outcomes in a Mn-Exposed African Community
NICHD (Key Personnel): Type One Diabetes in the Brain in Children: Metabolic Interventions
NICHD (Key Personnel): Ischemic Conditioning as a Neurorecovery Agent for Stroke
Children’s Discovery Institute (Key Personnel): Effects of Childhood Malnutrition on Brain Development
NIH/NCATS (Key Personnel): An Endoplasmic Reticulum Calcium Stabilizer for the Treatment of Wolfram Syndrome
DRTC (Co-Investigator): Neuroinflammation in Obesity