Professor of Psychiatry
- Phone: 314-362-2462
- Email: firstname.lastname@example.org
Additional Titles & Roles
- Director, Psychiatry Residency Training Program
- Co-Director, Animal Neuropathology Core Facility
- Inpatient Attending
- ECT Attending
Education & Training
- Residency: Washington University, St. Louis, MO, 1993
- MD: Washington University, St. Louis, MO, 1989
- BA: Washington University, St. Louis, MO, 1985
- Resident Mentoring Award, 2015
- Excellence in Teaching Award, 2013
- Excellence in Teaching Award, 1993
- The Sandoz Award, In recognition of superior academic achievement and contribution to health care, 1989
Areas of Clinical Interest
psychosis, ECT, Alzheimer’s disease, intellectual disabilities, schizophrenia, major depression, psychopharmacology
My research focuses are both clinical and basic science. Clinically I am currently studying the use of ketamine for treatment resistant depression. Our current goal is to evaluate the utility of a 96-hour subchronic dosing approach. In basic science I focus on the ability of neuroactive chemicals/compounds, prescribed drugs, and abused drugs to injure/kill neurons and glia in the CNS. Most of these agents appear to produce injury by inhibiting neuronal activity (e.g. NMDA antagonists, GABA mimetics, anticonvulsants). Other agents (e.g. solvents) have a less clear mechanism. Techniques used in the lab are pharmacological, histochemical (light and EM), neuroanatomical and cognitive/behavioral in nature. Results could be important for understanding childhood developmental disorders like mental retardation, autism, ADHD, Fetal Alcohol Syndrome as well as adult disorders such as schizophrenia, bipolar disorder and Alzheimer’s disease.
- Lenze EJ, Farber NB, Kharasch E, Schweiger J, Yingling M, Olney J, Newcomer JW (2016 Apr). Ninety-six hour ketamine infusion with co-administered clonidine for treatment-resistant depression: A pilot randomised controlled trial. World J Biol Psychiatry. (3):230-8
Read publication »Acute D2/D3 dopaminergic agonism but chronic D2/D3 antagonism prevents NMDA antagonist neurotoxicity.
- Farber NB, (2018 Nov). NMDA Antagonists for Treatment-Resistant Depression. Handb Exp Pharmacol.
Read publication »NMDA Antagonists for Treatment-Resistant Depression.
- Newcomer JW, Farber NB, Jevtovic-Todorovic V, Selke G, Melson AK, Hershey T, Craft S, Olney JW (1999 Feb). Ketamine-induced NMDA receptor hypofunction as a model of memory impairment and psychosis. Neuropsychopharmacology. 20(2): 106-18.
Read publication »Ketamine-induced NMDA receptor hypofunction as a model of memory impairment and psychosis.
- Farber NB (2003 Nov). The NMDA receptor hypofunction model of psychosis. Ann N Y Acad Sci. 1003119-30.
Read publication »The NMDA receptor hypofunction model of psychosis.
- Noguchi KK, Cabrera OH, Swiney BS, Salinas-Contreras P, Smith JK, Farber NB (2015 Nov). Hedgehog regulates cerebellar progenitor cell and medulloblastoma apoptosis. Neurobiol Dis. 83:35-43.
Read publication »Glucocorticoid receptor stimulation and the regulation of neonatal cerebellar neural progenitor cell apoptosis.
- Farber NB, Creeley CE, Olney JW (2010 Oct). Alcohol-induced neuroapoptosis in the fetal macaque brain. Neurobiol Dis. 40(1): 200-6.
Read publication »Alcohol-induced neuroapoptosis in the fetal macaque brain.
Funded Research Projects
James S. McDonnell Foundation(Significant Contributor):Reconstructing Consciousness and Cognition, Phase 2
NICHD(Significant Contributor):Washington University Intellectual and Developmental Disabilities Research Center
Missouri SCIDRP(Significant Contributor):Anesthesia Induced Apoptosis in the Developing Spinal Cord
NIDDK(Significant Contributor):Targeting Endoplasmic Reticulum for the Treatment of Wolfram Syndrome
ICTS(PI):Maintaining Response to Ketamine in Patients with Major Depression
NCATS(Significant Contributor):An Endoplasmic Reticulum Calcium Stabilizer for the Treatment of Wolfram Syndrome
NICHD(Significant Contributor):Anesthesia Toxicity in Neonatal Primate Brain
NIMH(Significant Contributor):Washington University Psychiatry Residency Research Education Program
NIMH(Significant Contributor):Brain and Cognitive Dynamics Following Electroconvulsive Therapy and Concurrent Anesthetic