Nuri Farber

Professor of Psychiatry

Additional Titles & Roles

  • Director, Psychiatry Residency Training Program
  • Co-Director, Animal Neuropathology Core Facility
  • Inpatient Attending
  • ECT Attending

Education & Training

  • Residency: Washington University, St. Louis, MO, 1993
  • MD: Washington University, St. Louis, MO, 1989
  • BA: Washington University, St. Louis, MO, 1985

Major Awards

  • Resident Mentoring Award, 2015
  • Excellence in Teaching Award, 2013
  • Excellence in Teaching Award, 1993
  • The Sandoz Award, In recognition of superior academic achievement and contribution to health care, 1989

Areas of Clinical Interest

psychosis, ECT, Alzheimer’s disease, intellectual disabilities, schizophrenia, major depression, psychopharmacology

Research Interests

My research focuses are both clinical and basic science. Clinically I am currently studying the use of ketamine for treatment resistant depression. Our current goal is to evaluate the utility of a 96-hour subchronic dosing approach. In basic science I focus on the ability of neuroactive chemicals/compounds, prescribed drugs, and abused drugs to injure/kill neurons and glia in the CNS. Most of these agents appear to produce injury by inhibiting neuronal activity (e.g. NMDA antagonists, GABA mimetics, anticonvulsants). Other agents (e.g. solvents) have a less clear mechanism. Techniques used in the lab are pharmacological, histochemical (light and EM), neuroanatomical and cognitive/behavioral in nature. Results could be important for understanding childhood developmental disorders like mental retardation, autism, ADHD, Fetal Alcohol Syndrome as well as adult disorders such as schizophrenia, bipolar disorder and Alzheimer’s disease.

Key Publications

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Funded Research Projects

James S. McDonnell Foundation(Significant Contributor):Reconstructing Consciousness and Cognition, Phase 2
NICHD(Significant Contributor):Washington University Intellectual and Developmental Disabilities Research Center
Missouri SCIDRP(Significant Contributor):Anesthesia Induced Apoptosis in the Developing Spinal Cord
NIDDK(Significant Contributor):Targeting Endoplasmic Reticulum for the Treatment of Wolfram Syndrome
ICTS(PI):Maintaining Response to Ketamine in Patients with Major Depression
NCATS(Significant Contributor):An Endoplasmic Reticulum Calcium Stabilizer for the Treatment of Wolfram Syndrome
NICHD(Significant Contributor):Anesthesia Toxicity in Neonatal Primate Brain
NIMH(Significant Contributor):Washington University Psychiatry Residency Research Education Program
NIMH(Significant Contributor):Brain and Cognitive Dynamics Following Electroconvulsive Therapy and Concurrent Anesthetic