Education & Training
- Residency: Washington University, St. Louis, MO, 2004
- ScD: Johns Hopkins University, Baltimore, Maryland, 1998
- MPH: Johns Hopkins University, Baltimore, Maryland, 1995
- MD: National Taiwan University, Taipei, Taiwan, 1993
- World Congress of Psychiatric Genetics Travel Award, 2009
- APA Resident Research Award, 2004
- Eli Robins Award, Washington University Department of Psychiatry, 2004
Areas of Clinical Interest
Schizophrenia, Mood Disorder, Addiction, Personality Disorder, Community Psychiatry, Telepsychiatry, Cancer Psychiatry
1. Precision medicine
2. Clinical trials
3. Genetics of smoking cessation and treatment
4. Implementation of smoking cessation treatment
5. Cross-population and longitudinal studies
6. Public health genomics
- Chen LS, Baker T, Brownson RC, Carney RM, Jorenby D, Hartz S, Smock N, Johnson M, Ziedonis D, Bierut LJ, (2016 Nov). Smoking Cessation and Electronic Cigarettes in Community Mental Health Centers: Patient and Provider Perspectives. Community Ment Health J. .
Read publication »Smoking Cessation and Electronic Cigarettes in Community Mental Health Centers: Patient and Provider Perspectives.
- Chen LS, Baker T, Hung RJ, Horton A, Culverhouse R, Hartz S, Saccone N, Cheng I, Deng B, Han Y, Hansen HM, Horsman J, Kim C, Rosenberger A, Aben KK, Andrew AS, Chang SC, Saum KU, Dienemann H, Hatsukami DK, Johnson EO, Pande M, Wrensch MR, McLaughlin J, Skaug V, van der Heijden EH, Wampfler J, Wenzlaff A, Woll P, Zienolddiny S, Bickeböller H, Brenner H, Duell EJ, Haugen A, Brüske I, Kiemeney LA, Lazarus P, Le Marchand L, Liu G, Mayordomo J, Risch A, Schwartz AG, Teare MD, Wu X, Wiencke JK, Yang P, Zhang ZF, Spitz MR, Amos CI, Bierut LJ, (2016 Sep). Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes – A Meta-Analysis. EBioMedicine. 11: 219-226.
Read publication »Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes – A Meta-Analysis.
- Chen LS, Hung RJ., Baker TB, Horton A, Culverhouse R, Saccone NL, Cheng I, Deng B, et al, Spitz, MR, Kraft P, Amos CI, Bierut LJ, 2015. CHRNA5 Risk Variant Predicts Delayed Smoking Cessation and Earlier Lung Cancer Diagnosis-A Meta-Analysis. J Natl Cancer Inst. 2015 Apr 14;107(5)
Read publication »CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis–a meta-analysis.
- Chen LS, Bloom AJ, Baker TB, Smith SS, Piper ME, Martinez M, Saccone N, Hatsukami D, Goate A, Bierut L (2014 Jan). Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene (CYP2A6). Addiction. 109(1): 128-37.
Read publication »Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene (CYP2A6).
- Chen LS, Baker TB, Piper ME, Breslau N, Cannon DS, Doheny KF, Gogarten SM, Johnson EO, Saccone NL, Wang JC, Weiss RB, Goate AM, Bierut LJ (2012 Jul 1). Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation success. Am J Psychiatry. 169(7): 735-42.
Read publication »Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation success.
- Chen LS, Baker, TB, Korpecki, JM, Johnson KE, Hook JP, Brownson RC, Bierut LJ. Low-burden strategies to promote smoking cessation treatment in patients with serious mental illness. Psychiatric Services. 2018 in press.
Read publication »Smoking and genetic risk variation across populations of European, Asian, and African American ancestry–a meta-analysis of chromosome 15q25.
Funded Research Projects
NIDA (PI): Genetically Informed Smoking Cessation Trial
NCI (Supplement PI): Cancer Center Tobacco Cessation
NIDA (Co-I): Nicotine Dependence to Smoking Cessation: Sequencing Common and Rare Variants
NCI (Co-I): Integrative Analysis of Lung Cancer Etiology and Risk
Taiwan NHRI (Co-I): Genetic Study of Addiction and Smoking Cessation