Missouri Twin Registry

Resource for genetic epidemiological and other clinical research

The Missouri Twin Study (MOTWIN) is composed of 1,630 male and female twins identified from the Missouri Twin Registry from 1996 through 2002 as part of a genetic epidemiological study of ADHD. Of these, 70 twins also participated in MOAFTS, and 1,521 of the 1,560 unique to MOTWIN had complete information on all 18 DSM-IV ADHD symptoms by parental report. Unlike MOAFTS and ATAP (below) which are population representative samples, a mild selective sampling scheme was applied during the recruitment of MOTWIN families: if either twin exhibited three or more present or past inattentive symptoms on a brief screening interview (N=564 families). In addition, an additional 104 families with a child with a CBCL anxious/withdrawn subscale score in the upper 95th percentile and 183 randomly selected families (across birth years) were enrolled in MOTWIN to address issues of rater bias and to serve as controls, respectively.19

Parental reports on offspring were collected with the Missouri Assessment for Genetic Studies of Children (MAGIC), a semi-structured interview based on DSM-IV diagnoses.20 The MAGIC demonstrates high inter-rater reliability and excellent stability of diagnosis for parental and offspring report of ADHD (alpha ≥ 0.79).20

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763481/