Division of Basic Science Research

This division focuses on understanding mechanisms of brain function and behavior in the context of psychiatric disease.

Division Director

Alexxai Kravitz

Associate Professor of Psychiatry

• Phone: 314-273-7956
• Email: alexxai@nospam.wustl.edu

Faculty

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Hongjin Shu

Assistant Professor of Psychiatry

• Phone: 314-362-8658
• Email: shuh@wustl.edu

Yun Ju Sung

Professor of Psychiatry

• Phone: 314-273-1967
• Email: yunju@wustl.edu

David Wozniak

Professor Emeritus of Psychiatry

• Phone: 314-286-1362
• Email: songb@psychiatry.wustl.edu

Carla Yuede

Professor of Psychiatry

• Phone: 314-362-9001
• Email: yuedec@wustl.edu

Charles Zorumski

Samuel B. Guze Professor of Psychiatry

• Phone: 314-747-2680
• Email: zorumskc@wustl.edu

Current Research Publications

• Persistence of vestibular function in the absence of glutamatergic transmission from hair cells
  November 30, 2026
  Persistence of vestibular function in the absence of glutamatergic transmission from hair cellsMukhopadhyay, M., Modgekar, R., Yang-Hood, A., Ohlemiller, K. K., Militchin, V., Xiao, M., Shen, Z., Rensing, N. R., Wong, M., Lee, S. J., Seal, R. P., Holt, J. C., Warchol, M. E., Maloney, S., Yuede, C. M., Rutherford, M. & Pangrsic, T., Dec 2026, In: Scientific reports. 16, 1, 14550.Research output: Contribution to journal › Article › peer-review
• A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia
  November 30, 2026
  A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementiaMirfakhar, F. S., Marsh, J. A., Sato, C., Schache, K. J., Minaya, M. A., Dolle, R. E., Pak, S. C., Silverman, G. A., Perlmutter, D. H., Macauley, S. L. & Karch, C. M., Dec 2026, In: Nature communications. 17, 1, 2699.Research output: Contribution to journal › Article › peer-review
• Association of LRRK2 p.A419V with Parkinson’s Disease in East Asians and analysis of age at onset
  November 30, 2026
  Association of LRRK2 p.A419V with Parkinson’s Disease in East Asians and analysis of age at onsetthe Global Parkinson’s Genetics Program (GP2), Dec 2026, In: npj Parkinson's Disease. 12, 1, 51.Research output: Contribution to journal › Article › peer-review
• Antecedent enhancer activity predicts future susceptibility to seizures in mice
  November 30, 2026
  Antecedent enhancer activity predicts future susceptibility to seizures in miceBoros, B. D., Gachechiladze, M. A., Guo, J., Galloway, D. A., Mueller, S. M., Shabsovich, M., Yen, A., Chen, X., Cammack, A. J., Shen, T., Mitra, R. D., Dougherty, J. D. & Miller, T. M., Dec 2026, In: Nature communications. 17, 1, 300.Research output: Contribution to journal › Article › peer-review
• OMG! A proteomic determinant of neurodegenerative resiliency
  November 30, 2026
  OMG! A proteomic determinant of neurodegenerative resiliencyDuggan, M. R., Oh, H. S. H., Frank, P., Gomez, G. T., Zweibaum, D., Cui, Y., Chen, J., Surapaneni, A., Blew, C. O., Dark, H. E., Joynes, C. M., Kandala, S., Bilgel, M., Farinas, A., Erus, G., Tian, Q., Candia, J., Pucha, K. A., Landman, B. A. & Dumitrescu, L. & 36 others, Hohman, T. J., Lewis, A., Moghekar, A., Siavoshi, F., Ali, M., Liu, M., Xu, Y., Western, D., Kaneko, N., Kato, S., Furuichi, M., Shibayama, M., Katsuno, M., Nishita, Y., Otsuka, R., Gottesman, R. F., Dammer, E. B., Seyfried, N. T., Levey, […]