Division of Basic Science Research

This division focuses on understanding mechanisms of brain function and behavior in the context of psychiatric disease.

Division Director

Alexxai Kravitz

Associate Professor of Psychiatry

• Phone: 314-273-7956
• Email: alexxai@nospam.wustl.edu

Faculty

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Yun Ju Sung

Professor of Psychiatry

• Phone: 314-273-1967
• Email: yunju@wustl.edu

Carla Yuede

Professor of Psychiatry

• Phone: 314-362-9001
• Email: yuedec@wustl.edu

Charles Zorumski

Samuel B. Guze Professor of Psychiatry

• Phone: 314-747-2680
• Email: zorumskc@wustl.edu

Current Research Publications

• Persistence of vestibular function in the absence of glutamatergic transmission from hair cells
  November 30, 2026
  Persistence of vestibular function in the absence of glutamatergic transmission from hair cellsMukhopadhyay, M., Modgekar, R., Yang-Hood, A., Ohlemiller, K. K., Militchin, V., Xiao, M., Shen, Z., Rensing, N. R., Wong, M., Lee, S. J., Seal, R. P., Holt, J. C., Warchol, M. E., Maloney, S. E., Yuede, C. M., Rutherford, M. A. & Pangrsic, T., Dec 2026, In: Scientific reports. 16, 1, 14550.Research output: Contribution to journal › Article › peer-review
• Genetic modifiers of APOE-ε4-associated cognitive decline
  November 30, 2026
  Genetic modifiers of APOE-ε4-associated cognitive declineThe Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer's Disease Genetics Consortium (ADGC) & The Alzheimer's Disease Sequencing Project (ADSP), Dec 2026, In: Nature communications. 17, 1, 2982.Research output: Contribution to journal › Article › peer-review
• Early syndecan-4 upregulation predicts cognitive and pathological trajectories in Alzheimer disease
  November 30, 2026
  Early syndecan-4 upregulation predicts cognitive and pathological trajectories in Alzheimer diseaseTarawneh, R., Moulder, K. L., Topouza, D. G., Kar, A., Qian, H. T., Pankratz, V. S., Timsina, J., Franklin, E. E., Schindler, S. E., Perrin, R. J., Ances, B. M., Benzinger, T. L. S., Hassenstab, J., Morris, J. C., Holtzman, D. M. & Cruchaga, C., Dec 2026, In: Alzheimer's Research and Therapy. 18, 1, 152.Research output: Contribution to journal › Article › peer-review
• Unraveling the genetic architecture of non-Huntington chorea: a biobank-scale study of rare variants and repeat expansions
  November 30, 2026
  Unraveling the genetic architecture of non-Huntington chorea: a biobank-scale study of rare variants and repeat expansionsSpanish Study Group for Genetics of Chorea members, Dec 2026, In: npj Genomic Medicine. 11, 1, 33.Research output: Contribution to journal › Article › peer-review
• A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia
  November 30, 2026
  A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementiaMirfakhar, F. S., Marsh, J. A., Sato, C., Schache, K. J., Minaya, M. A., Dolle, R. E., Pak, S. C., Silverman, G. A., Perlmutter, D. H., Macauley, S. L. & Karch, C. M., Dec 2026, In: Nature communications. 17, 1, 2699.Research output: Contribution to journal › Article › peer-review