Division of Basic Science Research

This division focuses on understanding mechanisms of brain function and behavior in the context of psychiatric disease.

Division Director

Alexxai Kravitz

Associate Professor of Psychiatry

• Phone: 314-273-7956
• Email: alexxai@nospam.wustl.edu

Faculty

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Yun Ju Sung

Professor of Psychiatry

• Phone: 314-273-1967
• Email: yunju@wustl.edu

Carla Yuede

Professor of Psychiatry

• Phone: 314-362-9001
• Email: yuedec@wustl.edu

Charles Zorumski

Samuel B. Guze Professor of Psychiatry

• Phone: 314-747-2680
• Email: zorumskc@wustl.edu

Current Research Publications

• Antecedent enhancer activity predicts future susceptibility to seizures in mice
  November 30, 2026
  Antecedent enhancer activity predicts future susceptibility to seizures in miceBoros, B. D., Gachechiladze, M. A., Guo, J., Galloway, D. A., Mueller, S. M., Shabsovich, M., Yen, A., Chen, X., Cammack, A. J., Shen, T., Mitra, R. D., Dougherty, J. D. & Miller, T. M., Dec 2026, In: Nature communications. 17, 1, 300.Research output: Contribution to journal › Article › peer-review
• Association of LRRK2 p.A419V with Parkinson’s Disease in East Asians and analysis of age at onset
  November 30, 2026
  Association of LRRK2 p.A419V with Parkinson’s Disease in East Asians and analysis of age at onsetthe Global Parkinson’s Genetics Program (GP2), Dec 2026, In: npj Parkinson's Disease. 12, 1, 51.Research output: Contribution to journal › Article › peer-review
• A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia
  November 30, 2026
  A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementiaMirfakhar, F. S., Marsh, J. A., Sato, C., Schache, K. J., Minaya, M. A., Dolle, R. E., Pak, S. C., Silverman, G. A., Perlmutter, D. H., Macauley, S. L. & Karch, C. M., Dec 2026, In: Nature communications. 17, 1, 2699.Research output: Contribution to journal › Article › peer-review
• OMG! A proteomic determinant of neurodegenerative resiliency
  November 30, 2026
  OMG! A proteomic determinant of neurodegenerative resiliencyDuggan, M. R., Oh, H. S. H., Frank, P., Gomez, G. T., Zweibaum, D., Cui, Y., Chen, J., Surapaneni, A., Blew, C. O., Dark, H. E., Joynes, C. M., Kandala, S., Bilgel, M., Farinas, A., Erus, G., Tian, Q., Candia, J., Pucha, K. A., Landman, B. A. & Dumitrescu, L. & 36 others, Hohman, T. J., Lewis, A., Moghekar, A., Siavoshi, F., Ali, M., Liu, M., Xu, Y., Western, D., Kaneko, N., Kato, S., Furuichi, M., Shibayama, M., Katsuno, M., Nishita, Y., Otsuka, R., Gottesman, R. F., Dammer, E. B., Seyfried, N. T., Levey, […]
• Retraction notice to “Generation of a gene-corrected human isogenic iPSC line from an Alzheimer’s disease iPSC line carrying thePSEN1 H163Rmutation” [Stem Cell Res. 79 (2024) 103495]
  May 31, 2026
  Retraction notice to “Generation of a gene-corrected human isogenic iPSC line from an Alzheimer’s disease iPSC line carrying thePSEN1 H163Rmutation” [Stem Cell Res. 79 (2024) 103495]Dominantly Inherited Alzheimer Network DIAN, Jun 2026, In: Stem Cell Research. 93, 103956.Research output: Contribution to journal › Comment/debate