Division of Basic Science Research

This division focuses on understanding mechanisms of brain function and behavior in the context of psychiatric disease.

Division Director

Alexxai Kravitz

Associate Professor of Psychiatry

• Phone: 314-273-7956
• Email: alexxai@nospam.wustl.edu

Faculty

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Hongjin Shu

Instructor in Psychiatry

• Phone: 314-362-8658
• Email: shuh@wustl.edu

Yun Ju Sung

Professor of Psychiatry

• Phone: 314-273-1967
• Email: yunju@wustl.edu

Carla Yuede

Professor of Psychiatry

• Phone: 314-362-9001
• Email: yuedec@wustl.edu

Charles Zorumski

Samuel B. Guze Professor of Psychiatry

• Phone: 314-747-2680
• Email: zorumskc@wustl.edu

Current Research Publications

• The LRRK2 p.L1795F variant causes Parkinson’s disease in the European population
  December 1, 2025
  The LRRK2 p.L1795F variant causes Parkinson’s disease in the European populationthe Global Parkinson’s Genetics Program (GP2), Dec 2025, In: npj Parkinson's Disease. 11, 1, 58.Research output: Contribution to journal › Article › peer-review
• The gain-of-function UBE3A^Q588E variant causes Angelman-like neurodevelopmental phenotypes in mice
  December 1, 2025
  The gain-of-function UBE3AQ588E variant causes Angelman-like neurodevelopmental phenotypes in miceWeston, K. P., Gunelson, A. M., Maloney, S., Ge, X., Stelzer, J. A., Kim, K. S., Collier, S., Mindt, M. M., Agajanian, M. J., Major, M. B., Goldfarb, D., Noguchi, K. & Yi, J., Dec 2025, In: Scientific reports. 15, 1, 9152.Research output: Contribution to journal › Article › peer-review
• Lifespan in rodents with MYT1L heterozygous mutation
  December 1, 2025
  Lifespan in rodents with MYT1L heterozygous mutationSchreiber, A., Swift, R. G., Wilson, L., Kroll, K. L., Dougherty, J. & Maloney, S., Dec 2025, In: Scientific reports. 15, 1, 4998.Research output: Contribution to journal › Article › peer-review
• Cross-ancestry genome-wide association study identifies implications of SORL1 in cerebral beta-amyloid deposition
  December 1, 2025
  Cross-ancestry genome-wide association study identifies implications of SORL1 in cerebral beta-amyloid depositionKim, J. P., Jung, S. H., Jang, B., Cho, M., Song, M., Kim, J., Kim, B., Lee, H., Shin, D., Lee, E. H., Jang, H., Kim, B. H., Ham, H., Kim, D., Raj, T., Cruchaga, C., Kim, H. J., Na, D. L., Seo, S. W. & Won, H. H., Dec 2025, In: Nature communications. 16, 1, 3150.Research output: Contribution to journal › Article › peer-review
• Effects of acute pro-inflammatory stimulation and 25-hydroxycholesterol on hippocampal plasticity and learning involve NLRP3 inflammasome and cellular stress responses
  December 1, 2025
  Effects of acute pro-inflammatory stimulation and 25-hydroxycholesterol on hippocampal plasticity and learning involve NLRP3 inflammasome and cellular stress responsesIzumi, Y., O’Dell, K. A., Mennerick, S. & Zorumski, C., Dec 2025, In: Scientific reports. 15, 1, 6149.Research output: Contribution to journal › Article › peer-review