Charles Zorumski
Samuel B. Guze Professor of Psychiatry
- Phone: 314-747-2680
- Email: zorumskc@nospam.wustl.edu
Additional Titles & Roles
- Director of the Taylor Family Institute for Innovative Psychiatric Research
- Professor of Neuroscience
- Chair, Center for Brain Research in Mood Disorders
Education & Training
- Residency: Washington University, St. Louis, MO, 1982
- M.D.: Saint Louis University, 1978
- B.A.: Saint Louis University, 1974
Major Awards
- Listed in America’s Top Doctors, Castle Connolly Medical Ltd, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019
- Listed in Best Doctors in America (Best Doctors, Inc), 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019
- Institute of Medicine, Forum on Neuroscience, 2009, 2010, 2011, 2012, 2013, 2014
- NIMH Board of Scientific Counselors (Intramural Program), 2009, 2010, 2011, 2012, 2013
- National Academy of Medicine (Institute of Medicine), National Academy of Sciences, 2012
Areas of Clinical Interest
Electroconvulsive therapy
Brain Stimulation Methods
Treatment refractory depression
Research Interests
Our laboratory is interested in physiology and pharmacology of amino acid neurotransmitters with emphasis on the regulation of responses at glutamate and GABA receptors. In our studies we use a variety of methods to examine modulation of the N-methyl-D-aspartate (NMDA) and AMPA/kainate classes of glutamate receptors. We are also examining the role of glutamate reeptors in synaptic transmission and long-term potentiation in the hippocampus. Other studies are directed at understanding the modulation of GABA and glutamate receptors by neurosteroids and oxysterols. Our clinical studies are examining the benefits and risks of electroconvulsive therapy (ECT) in various groups of patients with psychiatric disorders, including the use of ECT as a maintenance therapy.
Special Populations, Data Sets and Facilities
Facilities are available for preparing in vitro hippocampal cell cultures and hippocampal slices. Equipment for intra- and extracellular electrophysiological recording from cultured cells, tissue slices or living animals.
Recent Publications
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ARCH × Φ: Sterols and the evolution of gated biological execution
Rahman, T. & Zorumski, C. F., Jul 2026, In: BioSystems. 265, 105812.
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Rapid antidepressant potential of nitrous oxide: current state and major questions
Zorumski, C. F., Cichon, J., Izumi, Y., Zeffiro, T., Mennerick, S., Nagele, P. & Conway, C. R., Jun 2026, In: Molecular Psychiatry. 31, 6, p. 3022-3032 11 p.
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Structure-activity relationships of steroid and sterol neuromodulators on inflammatory markers in a murine microglial cell line
Shu, H. J., Covey, D. F., Zorumski, C. F. & Mennerick, S., May 2026, In: Journal of Steroid Biochemistry and Molecular Biology. 259, 106969.
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Durability of the benefit of vagus nerve stimulation in markedly treatment-resistant major depression: a RECOVER trial report
Conway, C. R., Rush, A. J., Aaronson, S. T., Bunker, M. T., Gordon, C., George, M. S., Riva-Posse, P., Allen, R. M., Nahas, Z., Kriedt, C. L., Zajecka, J., Dunner, D. L., Quevedo, J., Sheline, Y., Duffy, W., Mickey, B. J., Stedman, M., Alva, G., Manu, L. & Tran, Q. & 12 others, , Jan 1 2026, In: International Journal of Neuropsychopharmacology. 29, 1, pyaf080.
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An Exploratory Study of Machine Learning-Based Open-Angle Glaucoma Detection Using Specific Autoantibodies
Takada, N., Ishikawa, M., Ninomiya, T., Izumi, Y., Sato, K., Kunikata, H., Yokoyama, Y., Tsuda, S., Fukuda, E., Yamaguchi, K., Ono, C., Kirihara, T., Shintani, C., Hanyuda, A., Goshima, N., Zorumski, C. F. & Nakazawa, T., Dec 2025, In: Biomedicines. 13, 12, 3031.