Charles Zorumski

Additional Titles & Roles

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• Director of the Taylor Family Institute for Innovative Psychiatric Research
• Professor of Neuroscience
• Chair, Center for Brain Research in Mood Disorders

Education & Training

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• Residency: Washington University, St. Louis, MO, 1982
• M.D.: Saint Louis University, 1978
• B.A.: Saint Louis University, 1974

Major Awards

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• Listed in America’s Top Doctors, Castle Connolly Medical Ltd, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019
• Listed in Best Doctors in America (Best Doctors, Inc), 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019
• Institute of Medicine, Forum on Neuroscience, 2009, 2010, 2011, 2012, 2013, 2014
• NIMH Board of Scientific Counselors (Intramural Program), 2009, 2010, 2011, 2012, 2013
• National Academy of Medicine (Institute of Medicine), National Academy of Sciences, 2012

Areas of Clinical Interest

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Electroconvulsive therapy
Brain Stimulation Methods
Treatment refractory depression

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Research Interests

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Our laboratory is interested in physiology and pharmacology of amino acid neurotransmitters with emphasis on the regulation of responses at glutamate and GABA receptors. In our studies we use a variety of methods to examine modulation of the N-methyl-D-aspartate (NMDA) and AMPA/kainate classes of glutamate receptors. We are also examining the role of glutamate reeptors in synaptic transmission and long-term potentiation in the hippocampus. Other studies are directed at understanding the modulation of GABA and glutamate receptors by neurosteroids and oxysterols. Our clinical studies are examining the benefits and risks of electroconvulsive therapy (ECT) in various groups of patients with psychiatric disorders, including the use of ECT as a maintenance therapy.

Special Populations, Data Sets and Facilities
Facilities are available for preparing in vitro hippocampal cell cultures and hippocampal slices. Equipment for intra- and extracellular electrophysiological recording from cultured cells, tissue slices or living animals.

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Recent Publications

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• Nitrous oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect

  Cichon, J., Joseph, T. T., Lu, X., Wasilczuk, A. Z., Kelz, M. B., Mennerick, S. J., Zorumski, C. F. & Nagele, P., Dec 2025, In: Nature communications. 16, 1, 2999.

• Effects of acute pro-inflammatory stimulation and 25-hydroxycholesterol on hippocampal plasticity and learning involve NLRP3 inflammasome and cellular stress responses

  Izumi, Y., O’Dell, K. A., Mennerick, S. & Zorumski, C., Dec 2025, In: Scientific reports. 15, 1, 6149.

• New directions in neurosteroid therapeutics in neuropsychiatry

  Zorumski, C. F., Covey, D. F., Izumi, Y., Evers, A. S., Maguire, J. L. & Mennerick, S. J., May 2025, In: Neuroscience and Biobehavioral Reviews. 172, 106119.

• δ-Containing GABA_A receptors on parvalbumin interneurons modulate neuronal excitability and network dynamics in the mouse medial prefrontal cortex

  Lu, X., Shu, H. J., Lambert, P. M., Benz, A., Zorumski, C. F. & Mennerick, S., Apr 1 2025, In: Journal of neurophysiology. 133, 4, p. 1003-1013 11 p.

• Proteome-Wide Analysis of Autoantibodies in Open-Angle Glaucoma in Japanese Population: A Pilot Study

  Takada, N., Ishikawa, M., Sato, K., Kunikata, H., Ninomiya, T., Hanyuda, A., Fukuda, E., Yamaguchi, K., Ono, C., Kirihara, T., Shintani, C., Tsusu, C., Osanai, A., Goshima, N., Izumi, Y., Zorumski, C. F. & Nakazawa, T., Mar 2025, In: Biomedicines. 13, 3, 718.

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