Division of Basic Science Research

This division focuses on understanding mechanisms of brain function and behavior in the context of psychiatric disease.

Division Director

Alexxai Kravitz

Associate Professor of Psychiatry

• Phone: 314-273-7956
• Email: alexxai@nospam.wustl.edu

Faculty

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Kevin Noguchi

Associate Professor of Psychiatry

• Phone: 314-362-7007
• Email: noguchik@wustl.edu

Lari Niko-Petteri Nykanen

Instructor in Psychiatry

• Phone: 314-362-4476
• Email: nnykanen@wustl.edu

Marco Pignatelli

Assistant Professor of Psychiatry

• Phone: 314-273-3733
• Email: marco.pignatelli@wustl.edu

Yun Ju Sung

Professor of Psychiatry

• Phone: 314-273-1967
• Email: yunju@wustl.edu

Carla Yuede

Professor of Psychiatry

• Phone: 314-362-9001
• Email: yuedec@wustl.edu

Charles Zorumski

Samuel B. Guze Professor of Psychiatry

• Phone: 314-747-2680
• Email: zorumskc@wustl.edu

Current Research Publications

• Lifespan in rodents with MYT1L heterozygous mutation
  December 1, 2025
  Lifespan in rodents with MYT1L heterozygous mutationSchreiber, A., Swift, R. G., Wilson, L., Kroll, K. L., Dougherty, J. & Maloney, S., Dec 2025, In: Scientific reports. 15, 1, 4998.Research output: Contribution to journal › Article › peer-review
• Single-cell technology grows up: Leveraging high-resolution omics approaches to understand neurodevelopmental disorders
  June 1, 2025
  Single-cell technology grows up: Leveraging high-resolution omics approaches to understand neurodevelopmental disordersDougherty, J. D., Sarafinovska, S., Chaturvedi, S. M., Law, T. E., Akinwe, T. M. & Gabel, H. W., Jun 2025, In: Current Opinion in Neurobiology. 92, 102990.Research output: Contribution to journal › Review article › peer-review
• Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control
  April 7, 2025
  Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology controlCai, Z., Wang, S., Cao, S., Chen, Y., Penati, S., Peng, V., Yuede, C. M., Beatty, W. L., Lin, K., Zhu, Y., Zhou, Y. & Colonna, M., Apr 7 2025, In: The Journal of experimental medicine. 222, 4Research output: Contribution to journal › Article › peer-review
• The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway
  February 25, 2025
  The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathwayChen, H., Ferguson, C. J., Mitchell, D. C., Risch, I., Titus, A., Paulo, J. A., Hwang, A., Beck, L. K., Lin, T. H., Gu, W., Song, S. K., Yuede, C. M., Yano, H., Griffith, O. L., Griffith, M., Gygi, S. P., Bonni, A. & Kim, A. H., Feb 25 2025, In: Cell Reports. 44, 2, 115231.Research output: Contribution to journal › Article › peer-review
• ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep
  February 25, 2025
  ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleepConstantino, N. J., Carroll, C. M., Williams, H. C., Vekaria, H. J., Yuede, C. M., Saito, K., Sheehan, P. W., Snipes, J. A., Raichle, M. E., Musiek, E. S., Sullivan, P. G., Morganti, J. M., Johnson, L. A. & Macauley, S. L., Feb 25 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 8, e2416578122.Research output: Contribution to journal › Article › peer-review