Pamela Madden

Education & Training

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• Postdoctoral Fellowship: Washington University, St. Louis, MO, 1994
• Ph.D.: University of Pittsburgh, 1992
• M.S.: University of Pittsburgh, 1983
• B.S.: University of Pittsburgh, 1978

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Research Interests

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Dr. Madden has considerable expertise in diagnostic assessment and phenotype operationalization for genetic studies. She has a strong interest in the application of new genetic approaches in addiction research, pioneering the use of quantitative trait approaches in her own studies focused on cigarette smoking and tobacco dependence.

Her current research involves leadership of an international gene mapping project in which genetically informative data was collected from the Australian and Finnish families, to identify genes that contribute to vulnerability to dependence on nicotine and heavy smoking. This project includes extensive assessment also of alcohol use disorders and consumption patterns, because of their strong comorbidity with smoking and nicotine dependence.

In addition to her research activities, Dr. Madden has mentored several post-doctoral scholars in addiction genetics research and co-mentored many more with Dr. Andrew Heath. Together with Dr. John Rice, she co-directs a NIDA-funded R25 educational and training program which includes both US and foreign nationals for the development of statistical methods applied to addiction.

Recent Publications

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• Ethnic and racial differences in children and young people with respiratory and neurological post-acute sequelae of SARS-CoV-2: an electronic health record-based cohort study from the RECOVER Initiative

  RECOVER EHR and & RECOVER Pediatric Cohorts, Feb 2025, In: EClinicalMedicine. 80, 103042.

• Childhood Experiences of Corporal Punishment and Associated Intimate Partner Violence Perpetration and Victimization in Adulthood: Results from a Longitudinal Twin Study

  Poulsen, A., Mathews, B., Egan, N., Garwood-Gowers, A., Forder, P., Loxton, D., Madden, P., Heath, A. & Nelson, E., 2025, (Accepted/In press) In: Journal of Family Violence. 100044.

• Characterizing Long COVID in Children and Adolescents

  Gross, R. S., Thaweethai, T., Kleinman, L. C., Snowden, J. N., Rosenzweig, E. B., Milner, J. D., Tantisira, K. G., Rhee, K. E., Jernigan, T. L., Kinser, P. A., Salisbury, A. L., Warburton, D., Mohandas, S., Wood, J. C., Newburger, J. W., Truong, D. T., Flaherman, V. J., Metz, T. D., Karlson, E. W. & Chibnik, L. B. & 123 others, Pant, D. B., Krishnamoorthy, A., Gallagher, R., Lamendola-Essel, M. F., Hasson, D. C., Katz, S. D., Yin, S., Dreyer, B. P., Carmilani, M., Coombs, K., Fitzgerald, M. L., Güthe, N., Hornig, M., Letts, R. J., Peddie, A. K., Taylor, B. D., Foulkes, A. S., Stockwell, M. S., Balaraman, V., Bogie, A., Bukulmez, H., Dozor, A. J., Eckrich, D., Elliott, A. J., Evans, D. N., Farkas, J. S., Faustino, E. V. S., Fischer, L., Gaur, S., Harahsheh, A. S., Hasan, U. N., Hsia, D. S., Huerta-Montañez, G., Hummel, K. D., Kadish, M. P., Kaelber, D. C., Krishnan, S., Kosut, J. S., Larrabee, J., Lim, P. P. C., Michelow, I. C., Oliveira, C. R., Raissy, H., Rosario-Pabon, Z., Ross, J. L., Sato, A. I., Stevenson, M. D., Talavera-Barber, M. M., Teufel, R. J., Weakley, K. E., Zimmerman, E., Bind, M. A. C., Chan, J., Guan, Z., Morse, R. E., Reeder, H. T., Akshoomoff, N., Aschner, J. L., Bhattacharjee, R., Cottrell, L. A., Cowan, K., D’Sa, V. A., Fiks, A. G., Gennaro, M. L., Irby, K., Khare, M., Guttierrez, J. L., McCulloh, R. J., Narang, S., Ness-Cochinwala, M., Nolan, S., Palumbo, P., Ryu, J., Salazar, J. C., Selvarangan, R., Stein, C. R., Werzberger, A., Zempsky, W. T., Aupperle, R., Baker, F. C., Banich, M. T., Barch, D. M., Baskin-Sommers, A., Bjork, J. M., Bookheimer, S. Y., Brown, S. A., Casey, B. J., Chang, L., Clark, D. B., Dale, A. M., Dapretto, M., Ernst, T. M., Fair, D. A., Feldstein Ewing, S. W., Foxe, J. J., Freedman, E. G., Friedman, N. P., Garavan, H., Gee, D. G., Gonzalez, R., Gray, K. M., Heitzeg, M. M., Herting, M. M., Jacobus, J., Laird, A. R., Larson, C. L., Lisdahl, K. M., Luciana, M., Luna, B., Madden, P. A. F., McGlade, E. C., Müller-Oehring, E. M., Nagel, B. J., Neale, M. C., Paulus, M. P., Potter, A. S., Renshaw, P. F., Sowell, E. R., Squeglia, L. M., Tapert, S., Uddin, L. Q., Wilson, S. & Yurgelun-Todd, D. A., Oct 8 2024, In: JAMA. 332, 14, p. 1174-1188 15 p.

• Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals

  Million Veteran Program, Zhou, H., Kember, R. L., Deak, J. D., Xu, H., Toikumo, S., Yuan, K., Lind, P. A., Farajzadeh, L., Wang, L., Hatoum, A. S., Johnson, J., Lee, H., Mallard, T. T., Xu, J., Johnston, K. J. A., Johnson, E. C., Nielsen, T. T., Galimberti, M. & Dao, C. & 30 others, Levey, D. F., Overstreet, C., Byrne, E. M., Gillespie, N. A., Gordon, S., Hickie, I. B., Whitfield, J. B., Xu, K., Zhao, H., Huckins, L. M., Davis, L. K., Sanchez-Roige, S., Madden, P. A. F., Heath, A. C., Medland, S. E., Martin, N. G., Ge, T., Smoller, J. W., Hougaard, D. M., Børglum, A. D., Demontis, D., Krystal, J. H., Gaziano, J. M., Edenberg, H. J., Agrawal, A., Zhao, H., Justice, A. C., Stein, M. B., Kranzler, H. R. & Gelernter, J., Dec 2023, In: Nature medicine. 29, 12, p. 3184-3192 9 p.

• Methamphetamine-induced region-specific transcriptomic and epigenetic changes in the brain of male rats

  Miao, B., Xing, X., Bazylianska, V., Madden, P., Moszczynska, A. & Zhang, B., Dec 2023, In: Communications Biology. 6, 1, 991.

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Funded Research Projects

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View NIH Research