Muhammad Ali

Education & Training

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• Ph.D.: University of Luxembourg, 2019
• Ph.D.: University of Luxembourg, 2019
• M.S.: Universität des Saarlandes, 2014
• M.S.: Government College University, Faisalabad, 2013
• B.S.: Government College University, Faisalabad, 2010

Major Awards

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• EURON Mobility Grant, 2019
• Joint Programme – Neurodegenerative Disease (JPND) Doctoral Fellowship, 2015

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Research Interests

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Dr. Muhammad Ali is an Assistant Professor in the Department of Psychiatry at Washington University School of Medicine in St. Louis (WashU). His research focuses on identifying biomarkers and therapeutic targets for neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD). His work leverages large-scale, multi-platform proteomic datasets to uncover disease-specific and shared molecular signatures across tissues (cerebrospinal fluid and plasma) and disease stages.

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Recent Publications

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• OMG! A proteomic determinant of neurodegenerative resiliency

  Duggan, M. R., Oh, H. S. H., Frank, P., Gomez, G. T., Zweibaum, D., Cui, Y., Chen, J., Surapaneni, A., Blew, C. O., Dark, H. E., Joynes, C. M., Kandala, S., Bilgel, M., Farinas, A., Erus, G., Tian, Q., Candia, J., Pucha, K. A., Landman, B. A. & Dumitrescu, L. & 36 others, Hohman, T. J., Lewis, A., Moghekar, A., Siavoshi, F., Ali, M., Liu, M., Xu, Y., Western, D., Kaneko, N., Kato, S., Furuichi, M., Shibayama, M., Katsuno, M., Nishita, Y., Otsuka, R., Gottesman, R. F., Dammer, E. B., Seyfried, N. T., Levey, A. I., Erik, E. C., Mormino, E., Wagner, A. D., Poston, K. L., Kapogiannis, D., Grams, M. E., Bhargava, P., Waga, I., Davatzikos, C., Resnick, S. M., Ferrucci, L., Bennett, D. A., Cruchaga, C., Wyss-Coray, T., Kivimäki, M., Coresh, J. & Walker, K. A., Dec 2026, In: Molecular neurodegeneration. 21, 1, 9.

• Understanding Neurodegenerative Diseases From the −Omics Perspective: Lessons Learnt

  Ibanez, L., Pottier, C., Beric, A., Western, D., Ali, M. & Cruchaga, C., Mar 2026, In: Annals of neurology. 99, 3, p. 566-587 22 p.

• APOE-stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer’s Disease

  Li, F., Chen, Y., Western, D., Ali, M., Liu, M., Gong, K., Xu, Y., Lowery, J., Holtzman, D. M., Robins, C., Eicher, J. D., Huang, Y. N., Liu, S. W., Park, T., Saykin, A. J., Nho, K., Moqri, M., Mohs, R. C., Farinas, A. & Moran-Losada, P. & 3 others, Oh, H. S. H., Wyss-Coray, T. & Cruchaga, C., 2026, (Accepted/In press) In: Advanced Science.

• CSF proteomic profiling with amyloid and tau pathology identifies distinctive sex-specific alteration of multiple proteins involved in Alzheimer’s disease

  The Alzheimer’s Disease Neuroimaging Initiative (ADNI), Jan 2026, In: Alzheimer’s and Dementia. 22, 1, e71063.

• Temporal transcriptomic changes in the THY-Tau22 mouse model of tauopathy display cell type- and sex-specific differences

  Ali, M., Garcia, P., Lunkes, L. P., Sciortino, A., Thomas, M. H., Heurtaux, T., Grzyb, K., Halder, R., Skupin, A., Buée, L., Blum, D., Buttini, M. & Glaab, E., Dec 2025, In: Acta Neuropathologica Communications. 13, 1, 93.

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