Dr. Kelly N Botteron

Kelly Botteron

Professor of Psychiatry (Child)

Additional Titles & Roles

  • Professor of Radiology

Education & Training

  • Fellowship: Washington University, St. Louis, MO at St. Louis Children’s Hospital, 1993
  • Residency: Washington University, St. Louis, MO, 1991
  • M.D.: University of Kansas Medical Center, 1988
  • B.A.: University of Kansas, 1984

Major Awards

  • Peer selected for inclusion in St. Louis’s Best Doctors, 1999, 2000, 2001, 2002, 2003, 2004, 2005
  • Presidential Early Career Award for Scientists and Engineers; Executive Office of the President of the United States, 2001
  • Selected by NIH program staff to speak at the annual K Awardee meeting as a mentor, 2001
  • Betty Wahlstedt Memorial Scholarship – for outstanding achievement and academic promise in Anthropology, Psychology or Sociology, 1984
  • Kansas State University Dean’s Scholar Scholarship, 1980

Areas of Clinical Interest

Child and adolescent psychiatry, early onset depression, autism, pervasive developmental disorder, obsessive compulsive disorder, Tourette’s disorder, bipolar affective disorder, schizophrenia, neuropsychiatry

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Research Interests

My research investigates structural brain differences in children and adolescents with affective disorders, attention deficit disorder and autism. Including examination of structural MRI differences in discordant twin populations. We are involved in a longitudinal study to characterize very early brain development with MRI in infants at risk for developing autism and infants with Fragile X and Down Syndrome. In addition, in order to better understand structural abnormalities which we and others are demonstrating in children with psychiatric disorders, we are seeking to better characterize the progress of normal structural development and associated cognitive & behavioral development, by MRI, in healthy control populations. This research is done in collaboration with Robert McKinstry, M.D., Ph.D (Radiology), John R. Pruett, M.D., Ph.D. (Psychiatry), Natasha Marrus M.D., Ph.D. (Psychiatry), Josh Simony M.D. (Radiology) John N. Constantino, MD (Psychiatry, Pediatrics), Steve Petersen PhD (Neurology, Radiology) Alex Todorov, Ph.D. (Psychiatry), Deanna Barch, Ph.D. (Psychology); and David Van Essen, Ph.D. (Anatomy).

Secondary to ongoing neurodevelopmental changes, image analysis methodologies need specific validation and potential modifications for use in child populations. We are involved with Dr. Alan Evans (Montreal Neurological Institute) and Dr. Michael Miller and Dr. Tilak Ratnanather’s lab (Johns Hopkins University) on the application of newer image analysis techniques, including automated 3-D, high resolution, warping atlases for child and adolescent populations.

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Recent Publications

  • Longitudinal profiles of executive function in autistic and non-autistic children at high likelihood of autism

    IBIS Network, Dec 2026, In: Journal of neurodevelopmental disorders. 18, 1, 21.

  • Association of Maternal Smoking During Pregnancy With Childhood Blood Pressure and Hypertension in the ECHO Cohort

    Shorey-Kendrick, L. E., Ladd-Acosta, C., Zhao, H., Aschner, J. L., Breton, C. V., Camargo, C. A., Cassidy-Bushrow, A. E., Colicino, E., Dabelea, D., Dunlop, A. L., Farzan, S. F., Ferrara, A., Gern, J. E., Hertz-Picciotto, I., Karagas, M. R., Karr, C. J., Lester, B., Leve, L. D., Moore, B. F. & Neiderhiser, J. M. & 289 others, Oken, E., O’Shea, T. M., Sanderson, K., Stanford, J. B., Trasande, L., Weiss, S. T., Wright, R. J., Zhao, Q., Zhu, Y., McEvoy, C. T., Spindel, E. R., Smith, P. B., Newby, L. K., Adair, L., Jacobson, L. P., Catellier, D., McGrath, M., Douglas, C., Duggal, P., Knapp, E., Kress, A., Blackwell, C. K., Mansolf, M. A., Lai, J. S., Ho, E., Cella, D., Gershon, R., Macy, M. L., Das, S. R., Freedman, J. E., Mallal, S. A., McLean, J. A., Shah, R. V., Shilts, M. H., Alshawabkeh, A. N., Cordero, J. F., Meeker, J., Trasande, L., Camargo, C. A., Hasegawa, K., Zhu, Z., Sullivan, A. F., Dabelea, D., Perng, W., Bekelman, T. A., Wilkening, G., Magzamen, S., Moore, B. F., Starling, A. P., Rinehart, D. J., Mitchell, D. K., D’Sa, V., Deoni, S. C. L., Mueller, H. G., Duarte, C. S., Monk, C., Canino, G., Posner, J., Murray, T., Lugo-Candelas, C., Dunlop, A. L., Brennan, P. A., Hockett, C., Elliott, A., Ferrara, A., Croen, L. A., Hedderson, M. M., Ainsworth, J., Bacharier, L. B., Bendixsen, C. G., Gern, J. E., Gold, D. R., Hartert, T. V., Jackson, D. J., Johnson, C. C., Joseph, C. L. M., Kattan, M., Hershey, G. K. K., Lemanske, R. F., Lynch, S. V., Miller, R. L., O’Connor, G. T., Ober, C., Ownby, D., Rivera-Spoljaric, K., Ryan, P. H., Seroogy, C. M., Singh, A. M., Wood, R. A., Zoratti, E. M., Habre, R., Farzan, S., Gilliland, F. D., Hertz-Picciotto, I., Bennett, D. H., Schweitzer, J. B., Schmidt, R. J., LaSalle, J. M., Hipwell, A. E., Karr, C. J., Bush, N. R., LeWinn, K. Z., Sathyanarayana, S., Zhao, Q., Tylavsky, F., Carroll, K. N., Loftus, C. T., Leve, L. D., Ganiban, J. M., Neiderhiser, J. M., Weiss, S. T., Litonjua, A. A., McEvoy, C. T., Spindel, E. R., Tepper, R. S., Newschaffer, C. J., Lyall, K., Volk, H. E., Landa, R., Ozonoff, S., Piven, J., Hazlett, H., Pandey, J., Schultz, R., Dager, S., Botteron, K., Messinger, D., Stone, W., Ames, J., O’Connor, T. G., Miller, R. K., Oken, E., Hacker, M. R., James-Todd, T., O’Shea, T. M., Fry, R. C., Frazier, J. A., Singh, R., Rollins, C., Montgomery, A., Vaidya, R., Joseph, R. M., Washburn, L. K., Gogcu, S., Bear, K., Rollins, J. V., Hooper, S. R., Taylor, G., Jackson, W., Thompson, A., Daniels, J., Hernandez, M., Lu, K., Msall, M., Lenski, M., Obeid, R., Pastyrnak, S. L., Jensen, E., Sakai, C., Santos, H., Kerver, J. M., Paneth, N., Barone, C. J., Elliott, M. R., Ruden, D. M., Fussman, C., Herbstman, J. B., Margolis, A., Schantz, S. L., Geiger, S. D., Aguiar, A., Tabb, K., Strakovsky, R., Woodruff, T., Morello-Frosch, R., Padula, A., Stanford, J. B., Porucznik, C. A., Giardino, A. P., Wright, R. J., Wright, R. O., Collett, B., Baumann-Blackmore, N., Gangnon, R., Jackson, D. J., McKennan, C. G., Wilson, J., Altman, M., Aschner, J. L., Stroustrup, A., Merhar, S. L., Moore, P. E., Pryhuber, G. S., Hudak, M., Lyndaker, A. M. R., Lampland, A. L., Rochelson, B., Jan, S., Blitz, M. J., Katzow, M. W., Brown, Z., Chiuzan, C., Rafael, T., Lewis, D., Meirowitz, N., Poindexter, B., Gebretsadik, T., Osmundson, S., Straughen, J. K., Eapen, A., Cassidy-Bushrow, A., Wegienka, G., Sitarik, A., Woodcroft, K., Urquhart, A., Levin, A., Johnson-Hooper, T., Davidson, B., Ma, T., Barrett, E. S., Blaser, M. J., Dominguez-Bello, M. G., Horton, D. B., Jimenez, M., Rosen, T., Palomares, K., Avalos, L. A., Zhu, Y., Hunt, K. J., Newman, R. B., Bloom, M. S., Alkis, M. H., Roberts, J. R., Mumford, S. L., Burris, H. H., DeMauro, S. B., Yee, L. M., Hamvas, A., Olidipo, A. F., Haddad, A. S., Eiland, L. R., Spillane, N. T., Suri, K. N., Fisher, S. A., Goldstein, J. A., Mithal, L. B., DeRegnier, R. A. O., Maitre, N. L., Nguyen, R. H. N., JaKa, M. M., Sidebottom, A. C., Paidas, M. J., Potter, J. N. E., Ruby, N., Duthely, L., Jayakumar, A., Young, K., Maldonado, I., Miller, M., Slaughter, J. L., Keim, S. A., Lynch, C. D., Venkatesh, K. K., Whitworth, K. W., Symanski, E., Northrup, T. F., Mendez-Figueroa, H., Mosquera, R. A., Karagas, M. R., Madan, J. C., MacKenzie, D. M., Lewis, J. L., Rennie, B. J., Leventhal, B. L., Kim, Y. S., Bishop, S., Nozadi, S. S., Luo, L., Lester, B. M., Marsit, C. J., Everson, T., Loncar, C. M., McGowan, E. C., Sheinkopf, S. J., Carter, B. S., Check, J., Helderman, J. B., Neal, C. R. & Smith, L. M., Feb 17 2026, In: Circulation. 153, 7, p. 536-539 4 p.

  • Human cortical organoids recapitulate inter-individual variability in infant brain-growth trajectories

    The Infant Brain Imaging Study Network, Jan 8 2026, In: Cell Stem Cell. 33, 1, p. 142-156.e7

  • Predicting Cognitive Outcomes by Mapping White Matter Tracts to Surface

    Hong, Y., Azrak, O., Wolff, J. J., Swanson, M. R., Elison, J. T., Gerig, G., Pruett, J., Vachet, C., Botteron, K. N., Dager, S. R., Estes, A. M., Hazlett, H. C., Schultz, R., Shen, M. D., Zwaigenbaum, L., Evans, A., Collins, D. L., Fonov, V. S., Cornea, E. & Girault, J. B. & 7 others, Foster, M., Kim, S. H., Garic, D., Prieto, J. C., Piven, J., Gilmore, J. H. & Styner, M., 2026, Machine Learning in Medical Imaging – 16th International Workshop, MLMI 2025, Held in Conjunction with MICCAI 2025, Proceedings. Cui, Z., Rekik, I., Suk, H.-I., Ouyang, X., Sun, K. & Wang, S. (eds.). Springer Science and Business Media Deutschland GmbH, p. 594-603 10 p. (Lecture Notes in Computer Science; vol. 16241 LNCS).

  • Phenotype Representation and Analysis via Discriminative Atypicality (PRADA) to Capture the Structural Heterogeneity of Autism Spectrum Disorder

    Onemli, E., Mahmood, A., Azrak, O., Garic, D., Swanson, M. R., Grzadzinski, R., Mata, K., Shen, M. D., Girault, J. B., St. John, T., Pandey, J., Zwaigenbaum, L., Estes, A. M., Shen, A. M., Dager, S. R., Schultz, R. T., Botteron, K. N., Evans, A. C., Elison, J. T. & Yacoub, E. & 8 others, Kim, S. H., McKinstry, R., Gerig, G., Hazlett, H. C., Marrus, N., Piven, J., Pruett, J. & Styner, M., 2026, Medical Image Computing and Computer Assisted Intervention, MICCAI 2025 – 28th International Conference, 2025, Proceedings. Gee, J. C., Hong, J., Sudre, C. H., Golland, P., Alexander, D. C., Iglesias, J. E., Venkataraman, A. & Kim, J. H. (eds.). Springer Science and Business Media Deutschland GmbH, p. 473-483 11 p. (Lecture Notes in Computer Science; vol. 15961 LNCS).

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