Kelly Botteron

Kelly Botteron

Professor of Psychiatry (Child)

Additional Titles & Roles

  • Professor of Radiology

Education & Training

  • Fellowship: Washington University, St. Louis, MO at St. Louis Children’s Hospital, 1993
  • Residency: Washington University, St. Louis, MO, 1991
  • M.D.: University of Kansas Medical Center, 1988
  • B.A.: University of Kansas, 1984

Major Awards

  • Peer selected for inclusion in St. Louis’s Best Doctors, 1999, 2000, 2001, 2002, 2003, 2004, 2005
  • Presidential Early Career Award for Scientists and Engineers; Executive Office of the President of the United States, 2001
  • Selected by NIH program staff to speak at the annual K Awardee meeting as a mentor, 2001
  • Betty Wahlstedt Memorial Scholarship – for outstanding achievement and academic promise in Anthropology, Psychology or Sociology, 1984
  • Kansas State University Dean’s Scholar Scholarship, 1980

Areas of Clinical Interest

Child and adolescent psychiatry, early onset depression, autism, pervasive developmental disorder, obsessive compulsive disorder, Tourette’s disorder, bipolar affective disorder, schizophrenia, neuropsychiatry

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Research Interests

My research investigates structural brain differences in children and adolescents with affective disorders, attention deficit disorder and autism. Including examination of structural MRI differences in discordant twin populations. We are involved in a longitudinal study to characterize very early brain development with MRI in infants at risk for developing autism and infants with Fragile X and Down Syndrome. In addition, in order to better understand structural abnormalities which we and others are demonstrating in children with psychiatric disorders, we are seeking to better characterize the progress of normal structural development and associated cognitive & behavioral development, by MRI, in healthy control populations. This research is done in collaboration with Robert McKinstry, M.D., Ph.D (Radiology), John R. Pruett, M.D., Ph.D. (Psychiatry), Natasha Marrus M.D., Ph.D. (Psychiatry), Josh Simony M.D. (Radiology) John N. Constantino, MD (Psychiatry, Pediatrics), Steve Petersen PhD (Neurology, Radiology) Alex Todorov, Ph.D. (Psychiatry), Deanna Barch, Ph.D. (Psychology); and David Van Essen, Ph.D. (Anatomy).

Secondary to ongoing neurodevelopmental changes, image analysis methodologies need specific validation and potential modifications for use in child populations. We are involved with Dr. Alan Evans (Montreal Neurological Institute) and Dr. Michael Miller and Dr. Tilak Ratnanather’s lab (Johns Hopkins University) on the application of newer image analysis techniques, including automated 3-D, high resolution, warping atlases for child and adolescent populations.

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Recent Publications

  • Evaluating canonical babbling ratios extracted from day-long audio recordings in infants later diagnosed with autism spectrum disorder

    Meera, S. S., Swaminathan, D., Pawar, R., Yankowitz, L., Donovan, K., Khuu, K., Parish-Morris, J., Warren, S. F., Estes, A., Zwaigenbaum, L., Clements, M., Anderson, D. V., Schultz, R. T., Hazlett, H. C., John, T. S., Pandey, J., Marrus, N., Botteron, K., Dager, S. R. & Swanson, M. R. & 2 others, Watson, L. R. & Piven, J., Jun 2025, In: Infant Behavior and Development. 79, 102059.

  • Clarifying the developmental association between gesture and later vocabulary for autistic children

    for the IBIS Network, Jun 2025, In: Infant Behavior and Development. 79, 102058.

  • White matter microstructure in school-age children with down syndrome

    Garic, D., Al-Ali, K. W., Nasir, A., Azrak, O., Grzadzinski, R. L., McKinstry, R. C., Wolff, J. J., Lee, C. M., Pandey, J., Schultz, R. T., St. John, T., Dager, S. R., Estes, A. M., Gerig, G., Zwaigenbaum, L., Marrus, N., Botteron, K. N., Piven, J., Styner, M. & Hazlett, H. C. & 1 others, Shen, M. D., Jun 2025, In: Developmental Cognitive Neuroscience. 73, 101540.

  • Brain volumes, cognitive, and adaptive skills in school-age children with Down syndrome

    for the IBIS Network, Dec 2024, In: Journal of neurodevelopmental disorders. 16, 1, 70.

  • Host factors are associated with vaginal microbiome structure in pregnancy in the ECHO Cohort Consortium

    McKee, K., Bassis, C. M., Golob, J., Palazzolo, B., Sen, A., Comstock, S. S., Rosas-Salazar, C., Stanford, J. B., O’Connor, T., Gern, J. E., Paneth, N., Dunlop, A. L., Smith, P. B., Newby, L. K., Adair, L., Jacobson, L. P., Catellier, D., McGrath, M., Douglas, C. & Duggal, P. & 271 others, Knapp, E., Kress, A., Blackwell, C. K., Mansolf, M. A., Lai, J. S., Ho, E., Cella, D., Gershon, R., Macy, M. L., Das, S. R., Freedman, J. E., Mallal, S. A., McLean, J. A., Shah, R. V., Shilts, M. H., Alshawabkeh, A. N., Cordero, J. F., Meeker, J., Trasande, L., Camargo, C. A., Hasegawa, K., Zhu, Z., Sullivan, A. F., Dabelea, D., Perng, W., Bekelman, T. A., Wilkening, G., Magzamen, S., Moore, B. F., Starling, A. P., Rinehart, D. J., Mitchell, D. K., D’Sa, V., Deoni, S. C. L., Mueller, H. G., Duarte, C. S., Monk, C., Canino, G., Posner, J., Murray, T., Lugo-Candelas, C., Dunlop, A. L., Brennan, P. A., Hockett, C., Elliott, A., Ferrara, A., Croen, L. A., Hedderson, M. M., Ainsworth, J., Bacharier, L. B., Bendixsen, C. G., Gern, J. E., Gold, D. R., Hartert, T. V., Jackson, D. J., Johnson, C. C., Joseph, C. L. M., Kattan, M., Hershey, G. K. K., Lemanske, R. F., Lynch, S. V., Miller, R. L., O’Connor, G. T., Ober, C., Ownby, D., Rivera-Spoljaric, K., Ryan, P. H., Seroogy, C. M., Singh, A. M., Wood, R. A., Zoratti, E. M., Habre, R., Farzan, S., Gilliland, F. D., Hertz-Picciotto, I., Bennett, D. H., Schweitzer, J. B., Schmidt, R. J., LaSalle, J. M., Hipwell, A. E., Keenan, K. E., Karr, C. J., Bush, N. R., LeWinn, K. Z., Sathyanarayana, S., Zhao, Q., Tylavsky, F., Carroll, K. N., Loftus, C. T., Leve, L. D., Ganiban, J. M., Neiderhiser, J. M., Weiss, S. T., Litonjua, A. A., McEvoy, C. T., Spindel, E. R., Tepper, R. S., Newschaffer, C. J., Lyall, K., Volk, H. E., Landa, R., Ozonoff, S., Piven, J., Hazlett, H., Pandey, J., Schultz, R., Dager, S., Botteron, K., Messinger, D., Stone, W., Ames, J., O’Connor, T. G., Miller, R. K., Oken, E., Hacker, M. R., James-Todd, T., O’Shea, T. M., Fry, R. C., Frazier, J. A., Singh, R., Rollins, C., Montgomery, A., Vaidya, R., Joseph, R. M., Washburn, L. K., Gogcu, S., Bear, K., Rollins, J. V., Hooper, S. R., Taylor, G., Jackson, W., Thompson, A., Daniels, J., Hernandez, M., Lu, K., Msall, M., Lenski, M., Obeid, R., Pastyrnak, S. L., Jensen, E., Sakai, C., Santos, H., Kerver, J. M., Paneth, N., Barone, C. J., Elliott, M. R., Ruden, D. M., Fussman, C., Herbstman, J. B., Margolis, A., Schantz, S. L., Geiger, S. D., Aguiar, A., Tabb, K., Strakovsky, R., Woodruff, T., Morello-Frosch, R., Padula, A., Stanford, J. B., Porucznik, C. A., Giardino, A. P., Wright, R. J., Wright, R. O., Collett, B., Baumann-Blackmore, N., Gangnon, R., Jackson, D. J., McKennan, C. G., Wilson, J., Altman, M., Aschner, J. L., Stroustrup, A., Merhar, S. L., Moore, P. E., Pryhuber, G. S., Hudak, M., Lyndaker, A. M. R., Lampland, A. L., Rochelson, B., Jan, S., Blitz, M. J., Katzow, M. W., Brown, Z., Chiuzan, C., Rafael, T., Lewis, D., Meirowitz, N., Poindexter, B., Gebretsadik, T., Osmundson, S., Straughen, J. K., Eapen, A., Cassidy-Bushrow, A., Wegienka, G., Sitarik, A., Woodcroft, K., Urquhart, A., Levin, A., Johnson-Hooper, T., Davidson, B., Ma, T., Barrett, E. S., Blaser, M. J., Dominguez-Bello, M. G., Horton, D. B., Jimenez, M., Rosen, T., Palomares, K., Avalos, L. A., Zhu, Y., Hunt, K. J., Newman, R. B., Bloom, M. S., Alkis, M. H., Roberts, J. R., Mumford, S. L., Burris, H. H., DeMauro, S. B., Yee, L. M., Hamvas, A., Olidipo, A. F., Haddad, A. S., Eiland, L. R., Spillane, N. T., Suri, K. N., Fisher, S. A., Goldstein, J. A., Mithal, L. B., DeRegnier, R. A. O., Maitre, N. L., Nguyen, R. H. N., JaKa, M. M., Sidebottom, A. C., Paidas, M. J., Potter, J. N. E., Ruby, N., Duthely, L., Jayakumar, A., Young, K., Maldonado, I., Miller, M., Slaughter, J. L., Keim, S. A., Lynch, C. D., Venkatesh, K. K., Whitworth, K. W., Symanski, E., Northrup, T. F., Mendez-Figueroa, H., Mosquera, R. A., Karagas, M. R., Madan, J. C., MacKenzie, D. M., Lewis, J. L., Rennie, B. J., Leventhal, B. L., Kim, Y. S., Bishop, S., Nozadi, S. S., Luo, L., Lester, B. M., Marsit, C. J., Everson, T., Loncar, C. M., McGowan, E. C., Sheinkopf, S. J., Carter, B. S., Check, J., Helderman, J. B., Neal, C. R. & Smith, L. M., Dec 2024, In: Scientific reports. 14, 1, 11798.

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