Celeste Karch

Education & Training

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• Ph.D.: University of Florida, 2009

Major Awards

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• Chan Zuckerberg Initiative Neurodegeneration Challenge Network Investigator, 2019
• Dominantly Inherited Alzheimer’s Disease Young Investigator Award, 2017
• Charleston Conference on Alzheimer’s Disease Early Career Investigator, 2015
• NIH Early Career Reviewer, 2014
• Butler-Williams Scholar, 2013

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Research Interests

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neurodegeneration, neurogenetics, functional genomics, Alzheimer’s disease, frontotemporal dementia, tau, amyloid precursor protein, induced pluripotent stem cells (iPSC), cell and molecular biology, molecular mechanisms

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Recent Publications

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• GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau

  Acosta Ingram, D., Turkes, E., Kim, T. Y., Vo, S., Sweeney, N., Bonte, M. A., Rutherford, R., Julian, D. L., Pan, M., Marsh, J., Argouarch, A. R., Wu, M., Scharre, D. W., Bell, E. H., Honig, L. S., Vonsattel, J. P., Serrano, G. E., Beach, T. G., Karch, C. M. & Kao, A. W. & 3 others, Hester, M. E., Han, X. & Fu, H., Dec 2025, In: Nature communications. 16, 1, 3312.

• Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer’s disease

  Dominantly Inherited Alzheimer Network (DIAN), Dec 2025, In: Alzheimer’s Research and Therapy. 17, 1, 5.

• Somatic and Stem Cell Bank to study the contribution of African ancestry to dementia: African iPSC Initiative

  Maina, M. B., Isah, M. B., Marsh, J. A., Muhammad, Z., Babazau, L., Idris, A. A., Aladyeva, E., Miller, N., Starr, E., Miller, K. J., Lee, S., Minaya, M., Wray, S., Harari, O., Goni, B. W., Serpell, L. C. & Karch, C. M., Apr 2025, In: Alzheimer’s and Dementia. 21, 4, e70145.

• Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia

  on behalf of the Dominantly Inherited Alzheimer Network, Apr 2025, In: Nature medicine. 31, 4, p. 1267-1275 9 p., 1711.e15.

• Evaluating pathogenicity of variants of unknown significance in APP, PSEN1, and PSEN2

  Marsh, J. A., Huang, G., Bowling, K., Renton, A. E., Ziegemeier, E., Ball, T., Pottier, C., Cruchaga, C., Day, G., Bateman, R., Llibre-Guerra, J. J., McDade, E. & Karch, C. M., Apr 2025, In: Neurotherapeutics. 22, 3, e00527.

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Funded Research Projects

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