Carlos Cruchaga

Additional Titles & Roles

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• Professor of Neurology
• Professor of Genetics
• Professor of Genetics
• Professor of Neurology
• Knight-ADRC Genetics and Hight-throughput Omics Core leader
• DIAN (The Dominantly Inherited Alzheimer Network) Genetics Core co-leader
• Scientific advisor McDonnell Genome Institute (MGI)
• Director NeuroGenomics and Informatics lab

Education & Training

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• Ph.D.: University of Navarra, 2005
• M.S.: University of Navarra, 2002
• B.S.: University of Navarra, 2000

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Research Interests

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Dr. Cruchaga is a human genomicist with expertise in multiomics, informatics, and neurodegeneration. He completed his PhD in Biochemistry and Molecular Biology in 2005 at the University of Navarra in Spain. During his first postdoc with Dr. Pastor he conducted statistical human genetics studies focused on Alzheimer’s disease (AD) and Parkinson’s disease (PD). He then moved to Dr. Goate’s Lab to complete his training in quantitative human genomics. Dr. Cruchaga established his laboratory at Washington University in 2011 to study the genetic architecture of neurodegenerative diseases. His interests are focused on using human genomic and other -omic data (proteomics, metabolomics, and lipidomics) to identify and understand the biological processes that lead to AD, PD, frontotemporal dementia, and other neurodegenerative processes. He is the founding director of the NeuroGenomics and Informatics Center at Washington University.

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Recent Publications

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• Insights into ancestral diversity in Parkinson’s disease risk: a comparative assessment of polygenic risk scores

  the 23andMe Research Team & Global Parkinson’s Genetics Program (GP2), Dec 2025, In: npj Parkinson’s Disease. 11, 1, 201.

• Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer’s disease

  on behalf of Alzheimer’s Disease Genetics Consortium (ADGC), Dec 2025, In: Genome biology. 26, 1, 210.

• Methylome analysis of FTLD patients with TDP-43 pathology identifies epigenetic signatures specific to pathological subtypes

  Vicente, C. T., Niranjan, T., Coopman, E., Faura, J., Alidadiani, S., Schrauwen, C., Matchett, B. J., Heeman, B., Van den Broeck, M., De Coster, W., Nguyen, T., Lau, J. S., Baheti, S., de Pooter, T., De Rijk, P., Strazisar, M., Baker, M., DeJesus-Hernandez, M., Finch, N. C. A. & Pottier, C. & 29 others, van Blitterswijk, M., Asmann, Y., Murray, M. E., Petrucelli, L., King, A., Troakes, C., Al-Sarraj, S., Rissman, R. A., Hiniker, A., Flanagan, M., Evers, B. M., White, C. L., Cruchaga, C., Castellani, R., van Rooij, J. G. J., Mol, M. O., Seelaar, H., van Swieten, J. C., Oskarsson, B., Reichard, R. R., Nguyen, A. T., Josephs, K. A., Petersen, R. C., Ertekin-Taner, N., Boeve, B. F., Graff-Radford, N. R., Weckhuysen, S., Dickson, D. W. & Rademakers, R., Dec 2025, In: Molecular neurodegeneration. 20, 1, 80.

• Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing

  Pottier, C., Küçükali, F., Baker, M., Batzler, A., Jenkins, G. D., van Blitterswijk, M., Vicente, C. T., De Coster, W., Wynants, S., Van de Walle, P., Ross, O. A., Murray, M. E., Faura, J., Haggarty, S. J., van Rooij, J. G. J., Mol, M. O., Hsiung, G. Y. R., Graff, C., Öijerstedt, L. & Neumann, M. & 99 others, Asmann, Y., McDonnell, S. K., Baheti, S., Josephs, K. A., Whitwell, J. L., Bieniek, K. F., Forsberg, L., Heuer, H., Lago, A. L., Geier, E. G., Yokoyama, J. S., Oddi, A. P., Flanagan, M., Mao, Q., Hodges, J. R., Kwok, J. B., Domoto-Reilly, K., Synofzik, M., Wilke, C., Onyike, C., Dickerson, B. C., Evers, B. M., Dugger, B. N., Munoz, D. G., Keith, J., Zinman, L., Rogaeva, E., Suh, E. R., Gefen, T., Geula, C., Weintraub, S., Diehl-Schmid, J., Farlow, M. R., Edbauer, D., Woodruff, B. K., Caselli, R. J., Donker Kaat, L. L., Huey, E. D., Reiman, E. M., Mead, S., King, A., Roeber, S., Nana, A. L., Ertekin-Taner, N., Knopman, D. S., Petersen, R. C., Petrucelli, L., Uitti, R. J., Wszolek, Z. K., Ramos, E. M., Grinberg, L. T., Tempini, M. L. G., Rosen, H. J., Spina, S., Piguet, O., Grossman, M., Trojanowski, J. Q., Keene, C. D., Jin, L. W., Prudlo, J., Geschwind, D. H., Rissman, R. A., Cruchaga, C., Ghetti, B., Halliday, G. M., Beach, T. G., Serrano, G. E., Arzberger, T., Herms, J., Boxer, A. L., Honig, L. S., Vonsattel, J. P., Lopez, O. L., Kofler, J., White, C. L., Gearing, M., Glass, J., Rohrer, J. D., Irwin, D. J., Lee, E. B., Van Deerlin, V., Castellani, R., Mesulam, M. M., Tartaglia, M. C., Finger, E. C., Troakes, C., Al-Sarraj, S., Dalgard, C. L., Miller, B. L., Seelaar, H., Graff-Radford, N. R., Boeve, B. F., Mackenzie, I. R. A., van Swieten, J. C., Seeley, W. W., Sleegers, K., Dickson, D. W., Biernacka, J. M. & Rademakers, R., Dec 2025, In: Nature communications. 16, 1, 3914.

• European and African ancestry-specific plasma protein-QTL and metabolite-QTL analyses identify ancestry-specific T2D effector proteins and metabolites

  Yang, C., Gorijala, P., Timsina, J., Wang, L., Liu, M., Wang, C., Brock, W., Wang, Y., Urano, F., Sung, Y. J. & Cruchaga, C., Dec 2025, In: Nature communications. 16, 1, 7412.

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Funded Research Projects

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