Carlos Cruchaga

Additional Titles & Roles

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• Professor of Neurology
• Professor of Genetics
• Professor of Genetics
• Professor of Neurology
• Knight-ADRC Genetics and Hight-throughput Omics Core leader
• DIAN (The Dominantly Inherited Alzheimer Network) Genetics Core co-leader
• Scientific advisor McDonnell Genome Institute (MGI)
• Director NeuroGenomics and Informatics lab

Education & Training

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• Ph.D.: University of Navarra, 2005
• M.S.: University of Navarra, 2002
• B.S.: University of Navarra, 2000

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Research Interests

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Dr. Cruchaga is a human genomicist with expertise in multiomics, informatics, and neurodegeneration. He completed his PhD in Biochemistry and Molecular Biology in 2005 at the University of Navarra in Spain. During his first postdoc with Dr. Pastor he conducted statistical human genetics studies focused on Alzheimer’s disease (AD) and Parkinson’s disease (PD). He then moved to Dr. Goate’s Lab to complete his training in quantitative human genomics. Dr. Cruchaga established his laboratory at Washington University in 2011 to study the genetic architecture of neurodegenerative diseases. His interests are focused on using human genomic and other -omic data (proteomics, metabolomics, and lipidomics) to identify and understand the biological processes that lead to AD, PD, frontotemporal dementia, and other neurodegenerative processes. He is the founding director of the NeuroGenomics and Informatics Center at Washington University.

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Recent Publications

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• OMG! A proteomic determinant of neurodegenerative resiliency

  Duggan, M. R., Oh, H. S. H., Frank, P., Gomez, G. T., Zweibaum, D., Cui, Y., Chen, J., Surapaneni, A., Blew, C. O., Dark, H. E., Joynes, C. M., Kandala, S., Bilgel, M., Farinas, A., Erus, G., Tian, Q., Candia, J., Pucha, K. A., Landman, B. A. & Dumitrescu, L. & 36 others, Hohman, T. J., Lewis, A., Moghekar, A., Siavoshi, F., Ali, M., Liu, M., Xu, Y., Western, D., Kaneko, N., Kato, S., Furuichi, M., Shibayama, M., Katsuno, M., Nishita, Y., Otsuka, R., Gottesman, R. F., Dammer, E. B., Seyfried, N. T., Levey, A. I., Erik, E. C., Mormino, E., Wagner, A. D., Poston, K. L., Kapogiannis, D., Grams, M. E., Bhargava, P., Waga, I., Davatzikos, C., Resnick, S. M., Ferrucci, L., Bennett, D. A., Cruchaga, C., Wyss-Coray, T., Kivimäki, M., Coresh, J. & Walker, K. A., Dec 2026, In: Molecular neurodegeneration. 21, 1, 9.

• Association of LRRK2 p.A419V with Parkinson’s Disease in East Asians and analysis of age at onset

  the Global Parkinson’s Genetics Program (GP2), Dec 2026, In: npj Parkinson’s Disease. 12, 1, 51.

• Predicting accumulation and age at onset of amyloid-β from genetic risk and resilience for Alzheimer’s disease

  O’Brien, E. K., Cox, T., Fernandez, S., Bourgeat, P., Porter, T., Goudey, B., Doecke, J. D., Masters, C. L., Fripp, J., Nho, K., Villemagne, V. L., Cruchaga, C., Rowe, C. C., Saykin, A. J., Doré, V. & Laws, S. M., Jul 2026, In: EBioMedicine. 129, 106329.

• Retraction notice to “Generation of a gene-corrected human isogenic iPSC line from an Alzheimer’s disease iPSC line carrying thePSEN1 H163Rmutation” [Stem Cell Res. 79 (2024) 103495]

  Dominantly Inherited Alzheimer Network DIAN, Jun 2026, In: Stem Cell Research. 93, 103956.

• Usage and positivity rates of Alzheimer’s disease biomarkers in a memory clinic

  Hofmann, A., Saef, B., Powell, W. J. B., Paczynski, M., Ponisio, M. R., Vila-Castelar, C., Posey, Z., Oh, I. Y., Hofford, M. R., Aldinger, M., Bateman, R. J., Raji, C. A., Benzinger, T. L. S., Cruchaga, C., Dow, A., Buckley, R., Xiong, C., Morris, J. C., Snider, B. J. & Gupta, A. & 1 others, Schindler, S. E., May 2026, In: Alzheimer’s and Dementia. 22, 5, e71442.

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Funded Research Projects

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