Anil Cashikar

Additional Titles & Roles

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• Associate Professor of Neurology
• Member, Hope Center for Neurological Disorders
• Member, Taylor Family Insititute for Innovative Psychiatric Research

Education & Training

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• Ph.D.: Jawaharlal Nehru University, 1997
• M.S.: Madurai Kamaraj University, 1991
• B.S.: Bangalore University, 1989

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Research Interests

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Neuroinflammation is thought to play an important role in the pathogenesis of various psychiatric and neurological disorders. We are interested in understanding how cholesterol metabolism influences neuroinflammation.

Recent Publications

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• The phytosterol 24(S)-saringosterol alters lipid homeostasis and inflammatory pathways in a cell-specific manner

  Singh, M., Yu, J., Vanmierlo, T., Mulder, M. T., Paul, S. M. & Cashikar, A. G., Jun 2026, In: Biomedicine and Pharmacotherapy. 199, 119506.

• Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice

  Tabor, G. T., Litvinchuk, A., Chen, Y., Allison, A., Sun, E. W., van Lengerich, B., Davis, S. S., West, E., Schlachetzki, J. C. M., Zeng, C., Hu, H., Lin, P. B., Sharma, P., Chen, X., Parhizkar, S., Song, S., Bao, X., Senthil, L., Iyer, A. K. & You, S. F. & 17 others, Serrano, J. R., Manis, M., Franke, E., Cashikar, A. G., Yuede, C. M., Suh, J. H., Karch, C. M., Folick, A., Koliwad, S. K., Farese, R. V., Walther, T., Huang, E. J., Artyomov, M., Glass, C. K., Di Paolo, G., Ulrich, J. D. & Holtzman, D. M., Jan 27 2026, In: Cell Reports. 45, 1, 116841.

• 25-hydroxycholesterol promotes brain cytokine production and leukocyte infiltration in a mouse model of lipopolysaccharide-induced neuroinflammation

  Romero, J., Toral-Rios, D., Yu, J., Paul, S. M. & Cashikar, A. G., Dec 2024, In: Journal of Neuroinflammation. 21, 1, 251.

• Erratum: Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist (Neuron (2024) 112(3) (384–403.e8), (S0896627323008048), (10.1016/j.neuron.2023.10.023))

  Litvinchuk, A., Suh, J. H., Guo, J. L., Lin, K., Davis, S. S., Bien-Ly, N., Tycksen, E., Tabor, G. T., Serrano, J. R., Manis, M., Bao, X., Lee, C., Bosch, M., Perez, E. J., Yuede, C. M., Cashikar, A. G., Ulrich, J. D., Di Paolo, G. & Holtzman, D. M., Jun 19 2024, In: Neuron. 112, 12, p. 2079 1 p.

• Neurosteroids mediate and modulate the effects of pro-inflammatory stimulation and toll-like receptors on hippocampal plasticity and learning

  Izumi, Y., O’Dell, K. A., Cashikar, A. G., Paul, S., Covey, D. F., Mennerick, S. J. & Zorumski, C. F., Jun 2024, In: PloS one. 19, 6 June, e0304481.

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Funded Research Projects

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