Additional Titles & Roles
- Associate Professor of Neurology
- Member, Hope Center for Neurological Disorders
- Member, Taylor Family Insititute for Innovative Psychiatric Research
Education & Training
- Ph.D.: Jawaharlal Nehru University, 1997
- M.S.: Madurai Kamaraj University, 1991
- B.S.: Bangalore University, 1989
Research Interests
Neuroinflammation is thought to play an important role in the pathogenesis of various psychiatric and neurological disorders. We are interested in understanding how cholesterol metabolism influences neuroinflammation.
Recent Publications
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25-hydroxycholesterol promotes brain cytokine production and leukocyte infiltration in a mouse model of lipopolysaccharide-induced neuroinflammation
Romero, J., Toral-Rios, D., Yu, J., Paul, S. & Cashikar, A. G., Dec 2024, In: Journal of Neuroinflammation. 21, 1, 251.
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Neurosteroids mediate and modulate the effects of pro-inflammatory stimulation and toll-like receptors on hippocampal plasticity and learning
Izumi, Y., O’Dell, K. A., Cashikar, A. G., Paul, S., Covey, D. F., Mennerick, S. J. & Zorumski, C. F., Jun 2024, In: PloS one. 19, 6 June, e0304481.
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Erratum: Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist (Neuron (2024) 112(3) (384–403.e8), (S0896627323008048), (10.1016/j.neuron.2023.10.023))
Litvinchuk, A., Suh, J. H., Guo, J. L., Lin, K., Davis, S. S., Bien-Ly, N., Tycksen, E., Tabor, G. T., Serrano, J. R., Manis, M., Bao, X., Lee, C., Bosch, M., Perez, E. J., Yuede, C. M., Cashikar, A. G., Ulrich, J. D., Di Paolo, G. & Holtzman, D. M., Jun 19 2024, In: Neuron. 112, 12, p. 2079 1 p.
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Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy
Toral-Rios, D., Long, J. M., Ulrich, J. D., Yu, J., Strickland, M. R., Han, X., Holtzman, D. M., Cashikar, A. G. & Paul, S. M., Apr 1 2024, In: Journal of Experimental Medicine. 221, 4, e20232000.