Education & Training
- Ph.D.: Russia Academy of Science, 1987
- M.S.: Moscow State University, 1981
Research Interests
My research is concerned with linking genetics, brain function, and behavior for a better understanding of the determinants and consequences of substance use disorders and related psychopathology. A major theoretical premise of this work is that a deficit in prefrontally mediated inhibitory self-regulation of behavior constitutes a core component of vulnerability to substance use disorders (SUDs) and related externalizing psychopathology. A detailed characterization of the “disinhibitory” deficit, its genetic bases, developmental trajectory, and pathways by which it leads to addictive behaviors requires an integrative, multidisciplinary approach that combines genetics, cognitive neuroscience, and behavioral assessments. Accordingly, my laboratory is conducting interdisciplinary studies using a combination of neurophysiological (EEG/ERP) methods, neuropsychological, behavioral, and self-report assessments and, more recently, structural and functional magnetic resonance imaging (fMRI). One major goal of these studies is to identify neurocognitive characteristics, or “endophenotypes”, mediating genetic risk for substance use disorders and associated psychopathology using statistical analysis of twin data and molecular genetic methods. Another major goal of our studies is to determine how the use of substances such as alcohol, tobacco, and marijuana leads to long-term changes in brain function, cognition, and behavior. To achieve this goal, we are conducting prospective longitudinal studies and analyzing data from twin pairs who are discordant for substance use.
Recent Publications
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Correction to: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction (Nature Neuroscience, (2021), 24, 10, (1367-1376), 10.1038/s41593-021-00908-3)
COGA Collaborators, Jan 2025, In: Nature neuroscience. 28, 1, p. 213 1 p.
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Hippocampal volumes in UK Biobank are associated with APOE only in older adults
Chaloemtoem, A., Thornton, V., Chang, Y., Anokhin, A. P., Belloy, M. E., Bijsterbosch, J., Gordon, B. A., Hartz, S. M. & Bierut, L. J., Oct 1 2024, In: Alzheimer’s and Dementia: Diagnosis, Assessment and Disease Monitoring. 16, 4, e70024.
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Examining associations between genetic and neural risk for externalizing behaviors in adolescence and early adulthood
Brislin, S. J., Salvatore, J. E., Meyers, J. M., Kamarajan, C., Plawecki, M. H., Edenberg, H. J., Kuperman, S., Tischfield, J., Hesselbrock, V., Anokhin, A. P., Chorlian, D. B., Schuckit, M. A., Nurnberger, J. I., Bauer, L., Pandey, G., Pandey, A. K., Kramer, J. R., Chan, G., Porjesz, B. & Dick, D. M., Jan 19 2024, In: Psychological medicine. 54, 2, p. 267-277 11 p.
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Childhood trauma is associated with developmental trajectories of EEG coherence, alcohol-related outcomes, and PTSD symptoms
COGA Investigators, 2024, (Accepted/In press) In: Psychological medicine.
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Kenya Psychosis-Risk Outcomes Study (KePROS): Development of an Accelerated Medicine Partnership Schizophrenia-Aligned Project in Africa
Mamah, D., Mutiso, V., Musyimi, C., Harms, M. P., Anokhin, A. P., Chen, S. S., Torous, J., Muyela, L., Nashed, J., Al-Hosni, Y., Odera, A., Yarber, A., Golosheykin, S., Faghankhani, M., Sneed, M. & Ndetei, D. M., Jan 1 2024, In: Schizophrenia Bulletin Open. 5, 1, sgae009.