Abhirami Kannan Iyer

Education & Training

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• Ph.D.: Indiana University Indianapolis, 2016
• Ph.D.: Indiana University Indianapolis, 2016
• M.S.: University of Mumbai, 2009
• B.S.: University of Mumbai, 2007

Major Awards

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• CurePSP Pipeline and Pathway Grant, March 1, 2025 – February 28, 2027
• George Bartzokis Travel Award, New Vision Research, 11th Annual Charleston Conferences on Alzheimer’s Disease, 2023
• Hope Center for Neurological Disorders and the Washington University Institute of Clinical and Translational Sciences, Just-in-time (JIT) core usage award, 2022
• Indiana University School of Medicine postdoctoral travel grant for the Society for Neuroscience meeting, 2017
• Indiana University School of Medicine graduate student travel grant for the American Association of Immunologists meeting, 2014
• Indiana University Simon Cancer Center Annual Cancer Research Day, Honorable Mention in Basic Science Category by Graduate Student, 2013
• Junior Research Fellowship, Council of Scientific & Industrial Research, India, 2010

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Research Interests

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Neurodegeneration, Neuroimmunology, microglia, astrocytes

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Recent Publications

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• Targeted ASO-mediated Atp1a2 knockdown in astrocytes reduces SOD1 aggregation and accelerates disease onset in mutant SOD1 mice

  Iyer, K., Schoch, K. M., Verbeck, A., Galasso, G., Chen, H., Smith, S., Oldenborg, A., Miller, T. M., Karch, C. M. & Bonni, A., Nov 2023, In: PloS one. 18, 11 November, e0294731.

• Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation

  Filipello, F., You, S. F., Mirfakhar, F. S., Mahali, S., Bollman, B., Acquarone, M., Korvatska, O., Marsh, J. A., Sivaraman, A., Martinez, R., Cantoni, C., De Feo, L., Ghezzi, L., Minaya, M. A., Renganathan, A., Cashikar, A. G., Satoh, J. I., Beatty, W., Iyer, A. K. & Cella, M. & 3 others, Raskind, W. H., Piccio, L. & Karch, C. M., Jun 2023, In: Acta Neuropathologica. 145, 6, p. 749-772 24 p.

• Conserved gene signatures shared among MAPT mutations reveal defects in calcium signaling

  Minaya, M. A., Mahali, S., Iyer, A. K., Eteleeb, A. M., Martinez, R., Huang, G., Budde, J., Temple, S., Nana, A. L., Seeley, W. W., Spina, S., Grinberg, L. T., Harari, O. & Karch, C. M., Feb 9 2023, In: Frontiers in Molecular Biosciences. 10, 1051494.

• Cellular Sources and Neuroprotective Roles of Interleukin-10 in the Facial Motor Nucleus after Axotomy

  Runge, E. M., Setter, D. O., Iyer, A. K., Regele, E. J., Kennedy, F. M., Sanders, V. M. & Jones, K. J., Oct 2022, In: Cells. 11, 19, 3167.

• CD4+ T cell expression of the IL-10 receptor is necessary for facial motoneuron survival after axotomy

  Runge, E. M., Iyer, A. K., Setter, D. O., Kennedy, F. M., Sanders, V. M. & Jones, K. J., Apr 17 2020, In: Journal of Neuroinflammation. 17, 1, 121.

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