Charles Zorumski

Samuel B. Guze Professor of Psychiatry

Additional Titles & Roles


  • Head of the Department of Psychiatry
  • Director, Taylor Family Institute for Innovative Psychiatric Research
  • Chair, Center for Brain Research in Mood Disorders

Education & Training


  • Residency: Washington University, St. Louis, MO, 1982
  • MD: Washington University, St. Louis, MO, 1978
  • BA: Saint Louis University, St. Louis, MO, 1974

Major Awards


  • Listed in America’s Top Doctors, Castle Connolly Medical Ltd, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019
  • Listed in Best Doctors in America (Best Doctors, Inc), 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019
  • NIMH Board of Scientific Counselors (Intramural Program), 2009, 2010, 2011, 2012, 2013
  • Institute of Medicine, Forum on Neuroscience, 2009, 2010, 2011, 2012, 2013, 2014
  • National Academy of Medicine (Institute of Medicine), National Academy of Sciences, 2012

Areas of Clinical Interest


Electroconvulsive therapy
Brain Stimulation Methods
Treatment refractory depression

Research Interests


Our laboratory is interested in physiology and pharmacology of amino acid neurotransmitters with emphasis on the regulation of responses at glutamate and GABA receptors. In our studies we use a variety of methods to examine modulation of the N-methyl-D-aspartate (NMDA) and AMPA/kainate classes of glutamate receptors. We are also examining the role of glutamate reeptors in synaptic transmission and long-term potentiation in the hippocampus. Other studies are directed at understanding the modulation of GABA and glutamate receptors by neurosteroids and oxysterols. Our clinical studies are examining the benefits and risks of electroconvulsive therapy (ECT) in various groups of patients with psychiatric disorders, including the use of ECT as a maintenance therapy.

Special Populations, Data Sets and Facilities
Facilities are available for preparing in vitro hippocampal cell cultures and hippocampal slices. Equipment for intra- and extracellular electrophysiological recording from cultured cells, tissue slices or living animals.

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Key Publications


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Funded Research Projects


NIMH(co-PI):Oxysterols and NMDAR Function
NIMH: Neurosteroids & Proximal Inhibition in the Hippocampus