Celeste Karch

Education & Training

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• Ph.D.: University of Florida, 2009

Major Awards

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• Chan Zuckerberg Initiative Neurodegeneration Challenge Network Investigator, 2019
• Dominantly Inherited Alzheimer’s Disease Young Investigator Award, 2017
• Charleston Conference on Alzheimer’s Disease Early Career Investigator, 2015
• NIH Early Career Reviewer, 2014
• Butler-Williams Scholar, 2013

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Research Interests

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neurodegeneration, neurogenetics, functional genomics, Alzheimer’s disease, frontotemporal dementia, tau, amyloid precursor protein, induced pluripotent stem cells (iPSC), cell and molecular biology, molecular mechanisms

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Recent Publications

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• Lactate metabolism links reactive microglia, amyloid pathology, and Aβ dynamics

  Ashley, C. C., Constantino, N. J., Pettit-Mee, R. J., Snipes, J. A., Saito, K., Irmen, R. E., Zhang, R., Neary, E. M., Lanning, M. J., Karch, C. M., Johnson, L. A., Morganti, J. M. & Macauley, S. L., Dec 2026, In: Journal of Neuroinflammation. 23, 1, 201.

• A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia

  Mirfakhar, F. S., Marsh, J. A., Sato, C., Schache, K. J., Minaya, M. A., Dolle, R. E., Pak, S. C., Silverman, G. A., Perlmutter, D. H., Macauley, S. L. & Karch, C. M., Dec 2026, In: Nature communications. 17, 1, 2699.

• Retraction notice to “Generation of a gene-corrected human isogenic iPSC line from an Alzheimer’s disease iPSC line carrying thePSEN1 H163Rmutation” [Stem Cell Res. 79 (2024) 103495]

  Dominantly Inherited Alzheimer Network DIAN, Jun 2026, In: Stem Cell Research. 93, 103956.

• Integrative genomic and functional analyses reveal NINL as a modulator of tau aggregation

  Swift, S. K., Huang, G., Cochran, J. N., D’Oliveira Albanus, R., Minaya, M. A., Castruita, P. A., Zhang, R., Miller, K. J., Starr, E., Galasso, G., Marsh, J. A., Kao, A. W., Harari, O., Yokoyama, J. S. & Karch, C. M., Apr 2026, In: Alzheimer’s and Dementia. 22, 4, e71352.

• Longitudinal subcortical volume changes and their correlations with multiple PET and fluid biomarkers in dominantly inherited Alzheimer’s disease

  Choo, I. H., Park, H., Gordon, B. A., Bateman, R. J., Bateman, R., Daniels, A. J., Courtney, L., Ziegemeier, A., Skrbec, K., Hellm, C., Martin, M., Ziegemeier, E., Bartzel, J., McDade, E., Libre-Guerra, J. J., Supnet-Bell, C., Xiong, C., Xu, X., Lu, R. & Wang, G. & 106 others, Li, Y., Nie, Y., Gremminger, E., Perrin, R. J., Franklin, E., Ibanez, L., Jerome, G., Stauber, J., Baker, B., Minton, M., Cruchaga, C., Goate, A. M., Renton, A. E., Picarello, D. M., Fulton-Howard, B., Benzinger, T. L. S., Gordon, B. A., Banks, J., Hornbeck, R., Chen, A., Chen, C., Flores, S., Goyal, M., Hobbs, D., Joseph-Mathurin, N., Jackson, K., Keefe, S., Koudelis, D., Massoumzadeh, P., McCullough, A., McKay, N., Nicklaus, J., Pulizos, C., Wang, Q., Sabaredzovic, E., Scott, J., Simmons, A., Rizzo, J., Vlassenko, A., Wang, Y., Hassenstab, J., Smith, J., Stout, S., Aschenbrenner, A. J., Karch, C. M., Marsh, J., Morris, J. C., Holzman, D. M., Barthélemy, N. R., Xu, J., Berman, S. B., Ikonomovic, S., Day, G. S., Graff-Radford, N. R., Farlow, M., Chhatwal, J. P., Ikeuchi, T., Kasuga, K., Ishiguro, T., Ishii, K., Senda, M., Niimi, Y., Huey, E. D., Salloway, S., Devenney, E., Schofield, P. R., Brooks, W. S., Bechara, J. A., Martins, R., Fox, N. C., Cash, D. M., Ryan, N. S., Jucker, M., Laske, C., Timofejavaite, R., Kuder-Buletta, E., Graber-Sultan, S., la Fougère, C., Reischl, G., Obermueller, U., Levin, J., Rödenbeck, Y., Vöglein, J., Lee, J. H., Roh, J. H., Vitali, P., Allegri, R. F., Mendez, P. C., Surace, E., Vazquez, S., Aguillon, D., Leon, Y. M., Ramirez, L., Serna, L., Baena, A., Bocanegra, Y., Levey, A. I., Johnson, E. C. B., Seyfried, N. T., Ringman, J., Fagan, A. M., Mori, H., Masters, C., Nobles, J. M., Sanchez-Valle, R. & Lopera, F., Apr 2026, In: Journal of Prevention of Alzheimer’s Disease. 13, 4, 100513.

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Funded Research Projects

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