Carlos Cruchaga

Additional Titles & Roles

---

• Professor of Neurology
• Professor of Genetics
• Professor of Genetics
• Professor of Neurology
• Knight-ADRC Genetics and Hight-throughput Omics Core leader
• DIAN (The Dominantly Inherited Alzheimer Network) Genetics Core co-leader
• Scientific advisor McDonnell Genome Institute (MGI)
• Director NeuroGenomics and Informatics lab

Education & Training

---

• Ph.D.: University of Navarra, 2005
• M.S.: University of Navarra, 2002
• B.S.: University of Navarra, 2000

View clinician profile

Research Interests

---

Dr. Cruchaga is a human genomicist with expertise in multiomics, informatics, and neurodegeneration. He completed his PhD in Biochemistry and Molecular Biology in 2005 at the University of Navarra in Spain. During his first postdoc with Dr. Pastor he conducted statistical human genetics studies focused on Alzheimer’s disease (AD) and Parkinson’s disease (PD). He then moved to Dr. Goate’s Lab to complete his training in quantitative human genomics. Dr. Cruchaga established his laboratory at Washington University in 2011 to study the genetic architecture of neurodegenerative diseases. His interests are focused on using human genomic and other -omic data (proteomics, metabolomics, and lipidomics) to identify and understand the biological processes that lead to AD, PD, frontotemporal dementia, and other neurodegenerative processes. He is the founding director of the NeuroGenomics and Informatics Center at Washington University.

Visit lab website

Recent Publications

---

• Genome-wide association and population-tailored polygenic risk for Parkinson’s disease in Taiwan

  East Asian Parkinson Disease Genomics Consortium & Global Parkinson’s Genetics Program, Dec 2026, In: npj Parkinson’s Disease. 12, 1, 191.

• Exploring MAPT-containing H1 and H2 haplotypes in Parkinson’s disease across diverse populations

  the Latin American Research Consortium on the Genetics of Parkinson’s Disease (LARGE-PD) & the Global Parkinson’s Genetics Program (GP2), Dec 2026, In: npj Parkinson’s Disease. 12, 1, 187.

• GWAS meta-analysis of cerebrospinal fluid Alzheimer’s biomarkers reveals loci regulating lipids, brain volume and autophagy

  Timsina, J., Jiang, C., McCartney, D. L., Tao, F., Dalmasso, M. C., Najar, J., Anastasi, F., Ohlei, O., Puerta Fuentes, R., Yang, C., Bradley, J., Western, D., Ali, M., Wang, C., Yang, C., Wu, Y., Liu, M., Budde, J., Williams, J. & Mahoney, R. & 135 others, Castillo Morales, A., Hohman, T. J., Dumitrescu, L., Wang, T. C., Tesi, N., Kern, S., Waern, M., Skoog, I., van Harten, A., Pijnenburg, Y. A. L., van der Flier, W. M., Sánchez-Juan, P., Rodriguez-Rodriguez, E., Kleineidam, L., Peters, O., Schneider, A., Küçükali, F., Bellenguez, C., Grenier-Boley, B., Heikkinen, S., de Rojas, I., Rujescu, D., Scherbaum, N., Hausner, L., Düzel, E., Grimmer, T., Wiltfang, J., Vandenberghe, R., Engelborghs, S., Heilmann-Heimbach, S., Schmid, M., Tegos, T., Scarmeas, N., Dols-Icardo, O., Moreno, F., Pérez-Tur, J., Bullido, M. J., Sánchez-Valle, R., Álvarez, V., García-González, P., Mir, P., Real, L. M., Piñol-Ripoll, G., García-Alberca, J. M., Seelaar, H., Ramakers, I., Papma, J., Hulsman, M., Laske, C., Teipel, S., Priller, J., Perneczky, R., Buerger, K., Nöthen, M. M., Lewczuk, P., Kornhuber, J., Hampel, H., Giegling, I., Goldhardt, O., Diehl-Schmid, J., Andrade, V., Heneka, M. M. T., Frölich, L., Vogelgsang, J., Graff, C., Thonberg, H., Ullgren, A., Papenberg, G., Deleuze, J. F., Dufouil, C., Wagner, M., Jessen, F., Holstege, H., van Duijn, C., Lebouvier, T., Hannon, O., Leinonen, V., Soininen, H., Herukka, S. K., Giedraitis, V., Löwenmark, M., Kilander, L., Genius, P., Rodríguez, B., Luckett, E. S., Navarro, A., Cano, A., Marquié, M., Blennow, K., Zetterberg, H., Lleo, A., Boada, M., Ruiz, A., Lee, V. M. Y., Van Deerlin, V. M., Deming, Y., Johnson, S. C., Engelman, C. D., Pastor, P., Alvarez, I., Peskind, E. R., Heslegrave, A. J., Saykin, A. J., Nho, K., Schindler, S. E., Morris, J. C., Holtzman, D. M., McDade, E., Renton, A. E., Goate, A., Ibanez, L., Riemenschneider, M., Albert, M. S., Laws, S. M., Porter, T., O’Brien, E. K., Shaw, L. M., Tijms, B. M., Ingelsson, M., Visser, P. J., Hiltunen, M., Sleegers, K., Ritchie, C. W., Sims, R., Belloy, M., Lambert, J. C., Vilor-Tejedor, N., Fernández, M. V., Li, Q. S., Nagle, M. W., Marioni, R. E., Ramirez, A., Bertram, L., van der Lee, S. J. & Cruchaga, C., Dec 2026, In: Nature communications. 17, 1, 7385.

• Genome-wide association study of copy number variations in Parkinson’s disease

  the Global Parkinson Genetics Program (GP2) & Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease (COURAGE-PD) consortium, Dec 2026, In: npj Parkinson’s Disease. 12, 1, 160.

• Author Correction: TMEM175, SCARB2 and CTSB associations with Parkinson’s disease risk across populations (npj Parkinson’s Disease, (2025), 11, 1, (348), 10.1038/s41531-025-01180-z)

  the Global Parkinson’s Genetic Program (GP2), Dec 2026, In: npj Parkinson’s Disease. 12, 1, 93.

See more publications

See NCBI publications

Funded Research Projects

---

View NIH Research