Miguel Minaya
Assistant Professor of Psychiatry
- Phone: 314-273-8145
- Email: miguel.minaya@nospam.wustl.edu
Education & Training
- Postdoctoral Research Associate: Washington University in Saint Louis School of Medicine, 2022
- Postdoctoral Fellow: Saint Louis University, 2019
- D.Sc.: Universidad Automoma de Madrid, 2015
Major Awards
- Early Career Reviewer program. NIH, This competitive program trains early-career scientists in peer review for NIH grant applications, 2024
- Mentored Research Scientist Development Award (K01), Molecular drivers of tauopathies in stem cell models from diverse human populations, 2023
- Butler-Williams Scholars Program. NIA, This competitive program trains researchers in aging and health disparities., 2023
- Knight ADRC REC, The competitive REC scholar program supports research training in aging and dementia studies, 2022
- Doctoral Student Research Award, This competitive research award by Spain’s Ministry of Science funds and supports PhD research, 2007
- Graduate Research Fellowship, This competitive fellowship trains graduate students for research under faculty guidance, 2005
- Undergraduate Research Award, This competitive research award at UAM, Spain, recognizes and funds outstanding student research, 2004
- The Undergraduate Fellowship, This fellowship by Spain’s Ministry of Science and Education funds and supports student research, 2000
Research Interests
My research primarily focuses on coupling stem cell modeling with genomic approaches to determine whether there is a common molecular mechanism that links the existence of certain MAPT mutations to the surge in tauopathies observed when they are present. To this end, I study transcriptomic profiles of iPSC-neurons, -astrocytes and -microglia carrying disease-related mutations and compare them to isogenic controls created using CRISPR/Cas9 protocols.
My long-term goal is to use ever more powerful novel approaches such as CRISPRi for multimodal genetic screening in human cell lines to understand more deeply the functions of several molecular drivers of disease and how to target these signatures to treat disease.
Recent Publications
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Mutant tau and stress lead to downregulation of long noncoding RNA, SNHG8
Bhagat, R., Minaya, M. A., Renganathan, A., Mehra, M., Marsh, J., Martinez, R., Eteleeb, A. M., Nana, A. L., Spina, S., Seeley, W. W., Grinberg, L. T. & Karch, C. M., Nov 2023, In: Molecular Psychiatry. 28, 11, p. 4489 1 p.
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Long non-coding RNA SNHG8 drives stress granule formation in tauopathies
Bhagat, R., Minaya, M. A., Renganathan, A., Mehra, M., Marsh, J., Martinez, R., Eteleeb, A. M., Nana, A. L., Spina, S., Seeley, W. W., Grinberg, L. T. & Karch, C. M., Nov 2023, In: Molecular Psychiatry. 28, 11, p. 4889-4901 13 p.
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Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation
Filipello, F., You, S. F., Mirfakhar, F. S., Mahali, S., Bollman, B., Acquarone, M., Korvatska, O., Marsh, J. A., Sivaraman, A., Martinez, R., Cantoni, C., De Feo, L., Ghezzi, L., Minaya, M. A., Renganathan, A., Cashikar, A. G., Satoh, J. I., Beatty, W., Iyer, A. K. & Cella, M. & 3 others, , Jun 2023, In: Acta Neuropathologica. 145, 6, p. 749-772 24 p.
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Conserved gene signatures shared among MAPT mutations reveal defects in calcium signaling
Minaya, M. A., Mahali, S., Iyer, A. K., Eteleeb, A. M., Martinez, R., Huang, G., Budde, J., Temple, S., Nana, A. L., Seeley, W. W., Spina, S., Grinberg, L. T., Harari, O. & Karch, C. M., Feb 9 2023, In: Frontiers in Molecular Biosciences. 10, 1051494.