Faculty

Grants

Principal Investigator Funded Research
Arpana Agrawal, PhD NIDA(PI):Cannabis, Depression and Suicidal Thoughts and Behaviors

NIDA(PI):Cannabis and Tobacco Involvement: A Twin Study

NIDA(Co-PI):Non-Dependent Opioid Misusers as GWAS Controls

NIDA(PI):Delineating the Role of Genetic Influences on Cannabis Involvement

NIMH(co-PI):7/7 Psychiatric Genomics Consortium: Finding Actionable Variation

Andrey P. Anokhin, PhD NICHD(PI):Genetics, the Adolescent Brain, and Addiction Liability: A Longitudinal Twin Study
NIDA(PI):Neurocognitive Consequences of Adolescent Marijuana Use
NIDA(PI):Test-Retest Reliability of Putative fMRI Endophenotypes for Substance Abuse Risk
NIAAA(Significant Contributor):Collaborative Study on the Genetics of Alcoholism (COGA)
Andy Belden, PhD NIMH(PI):Neurobehavioral Correlates of Emotion Regulation in Healthy & Depressed Children

McDonnell Center for Systems Neuroscience (PI): Neurobiological Correlates of Cognitive Emotion Regulation in Healthy Children

NIMH(Key Personnel):Preschool Mood Disorders: Developmental Continuity and School Age Outcomes

1K01MH090515-01
Laura Jean Bierut, MD NIAAA (Co-PI):Collaborative Study on the Genetics of Alcoholism
NIDA (PI): Nicotine Dependence to Smoking Cessation: Sequencing Common and Rare Variants
NIDA (PI): Washington University Career Development Program in Drug Abuse and Addiction
NIDA (Co-investigator): Smoking, Suicide and Mental Health: Using Policy Change to Probe Causality
NIDA (Co-investigator): Integrating Epigenomics in Human Brain and Genomics of Nicotine Dependence
NIDA (Co-investigator): Enhancing Discovery of HIV Host Genetics Using Drug Abuse and Other Interactions
NIMH (Co-investigator): Center for Genomic Studies on Mental Disorders
NCI (Key Personnel): Cancer Center Support Grant
Kevin J. Black, MD NIMH(PI):The New Tics study: A novel approach to pathophysiology and cause of tic disorders
Michael J. Fox Foundation for Parkinson's Research(PI):Dopamine Buffering Capacity Measured by PHMRI as a Novel Biomarker of Disease Progression in PD
NIDDK(Significant Contributor):Early Predictors of Brain Health and Development in Youth with T1DM
Tourette Association of America(Significant Contributor):Testing a Pathophysiological Model of Complex Tics
Tourette Association of America(Significant Contributor):Network Architecture of the Brain in Tourette Syndrome and its Phenotypic Subgroups
Barnes-Jewish Hospital Foundation(Significant Contributor):Complex Effects of Dietary Manipulation on Metabolic Function, Inflammation and Health
NICHD(Key Personnel):Tracking Neurodegeneration in Early Wolfram Syndrome
Neurocrine Biosciences, Inc.(site PI):An Open-Label, Safety and Tolerability Study of NBI-98854 for the Treatment of Subjects with Tourette Syndrome (NBI-98854-1601)
Joseph Bloom, PhD NIDA(PI):Novel Approaches to Investigate Genetic Correlates of Smoking Behaviors
Kelly N. Botteron, MD NIMH (PI):Neuroimaging in Early Onset Depression: Longitudinal Assessment of Brain Changes
NICHD(Site PI):A Longitudinal MRI Study of Infants at Risk for Autism
NIMH(Site PI):3D Shape Analysis for Computational Anatomy
NICHD(Site PI):A Longitudinal MRI Study of Brain Development in Infants with Fragile X Syndrome
NIMH(PI):Novel Cortical Limbic Analysis in Twins Discordant for ADHD
NIMH(Co-PI):Neuroimaging in Early Onset Depression: Longitudinal Assessment of Brain Changes
Kathleen K. Bucholz, PhD
NIAAA(Significant Contributor):Distinctions Between Black and White Young Women in the Course of Alcohol Use
NIAAA(Significant Contributor):Enriching Alcoholism Cohort and Population Studies
NIAAA(Significant Contributor):Collaborative Study on the Genetics of Alcoholism (COGA)
NIAAA(Significant Contributor):Outcomes of Recurrent DUI-Moms & their Children
NIAAA(PI):Outcomes of Recurrent DUI-Moms & Their Children
NIAAA(Significant Contributor):Neighborhood, Family and Individual Factors in Adolescent Drinking
NIAAA(Significant Contributor):Pharmacokinetics and Subjective Responses to Alcohol after Bariatric Surgery
NIDA(Significant Contributor):Cannabis, Depression and Suicidal Thoughts and Behaviors

Robert M. Carney, PhD NHLBI (PI): Omega-3 for Depression and Other Cardiac Risk Factors
NHLBI (Co-Investigator): Depression and Rehospitalization in Patients with Heart Failure


Patricia Cavazos-Rehg, PhD NIDA(PI):Building on Bridging the Gap: Environmental Influences on Teen Substance Use
NIDA(PI):Implications of Social Media Content and Engagement for Alcohol and Marijuana Use
NIMH(PI):Understanding Depression Displays on Twitter and Identifying Ways to Intervene
NIMH(PI):Investigating the Promotion of Eating Disorders on Twitter: Implications for Online Intervention
Li-Shiun Chen, MD NIDA (PI): Genetic and Environmental Risks for Smoking Characteristics and Cessation
NIDA (PI): Genetically Informed Smoking Cessation Trial
Vesselin Chorbov, PhD NIAAA(PI):Behavior and Epigenetic Effects of Chronic Alcohol Exposure in Rats and Human DNA
Theodore Cicero, PhD NIDA(PI):Biomedical Research Training in Drug Abuse
NIDA(Key Personnel):Prescription Drug Misuse, Abuse and Dependence
NIDA(Key Personnel):Understanding the Scope and Magnitude of Prescription Drug Diversion
Barnes-Jewish Hospital Foundation(PI):Characteristics of Prescription Drug Abusers
Unrestricted grant from Denver Health and Hospital Authority
C. Robert Cloninger, MD, PhD NIAAA (SUNY)(Key Personnel):Collaborative Study on the Genetics of Alcoholism
NIMH(PI):Molecular Genetics of Schizophrenia
NIMH(Key Personnel):Mapping Abnormal Neurodevelopment in Schizophrenia
John Constantino, MD Administration for Children and Families (Co-PI)
Buffering Toxic Stress: Novel Application of Intensive Group-based Parent Training

Missouri Department of Mental Health (PI): Autism Spectrum Disorder Wait list Reduction and Training Services

CDC (PI): Metropolitan St. Louis Autism & Developmental Disabilities Surveillance & Epidemiology

NIMH (Co- PI): ACE Network: A Comprehensive Approach to the Identification of Autism Susceptibility Genes

NICHD (PI): Washington University Intellectual and Developmental Disabilities Research Center

NICHD (PI): Sex Specific Modulation of ASD liability: compensatory mechanisms and recurrence (IDDRC)

St. Louis County Children’s Service Fund (PI): Comprehensive Approach to Unmet Mental Health Needs of Preschool Children in Foster Care, Phase 1

NICHD (PI): Early Quantitative Characterization of Reciprocal Social Behavior

CDC (PI): Missouri Autism Centers of Excellence Collaborative Study to Explore Early Development
Charles Conway, MD American Foundation of Suicide Prevention (Co-PI). Adjunctive Nitrous Oxide for Acute Suicidal Ideation in Unipolar Depressed Hospitalized Patients.

Assurex Health (PI). Combinatorial Pharmacogenomics Testing in Treatment-Naïve Major Depressive Disorder (MDD).

Brain and Behavior Research Foundation (Co-I). Inhaled Nitrous Oxide for Treatment-Resistant Depression: Optimizing Dosing Strategies.

Stanley Medical Research Institute (Co-PI). Nitrous Oxide for Bipolar Depression.

NIMH R21 (Co-PI). Targeting Affective Circuits Using the N-methyl-D-Aspartate (NMDA) Antagonist Nitrous Oxide.

McDonnell Center for Systems Neuroscience (Co-PI): Assessing Effects of Nitrous Oxide Inhalation on Functional Connectivity.

Taylor Family Institute for Innovative Psychiatric Research (PI): Biological and Psychological Phenomenology Studies of Treatment-Resistant Depressive Disorder.
Carlos Cruchaga, PhD NIA(PI): Identifying Rare Variants that Increase Risk for Alzheimer's Disease
NINDS(Co-PI):Genetic Architecture of Acute Human Brain Ischemia
NIA(PI): Identification of genetic variants associated with rate of disease progression
BrightFocus Foundation(PI):Identification of Novel CSF Endophenotypes and Genetic Variants for AD by Mendelian Randomization
American Federation for Aging Research, Inc.(PI):Identification of Additional Risk Variants and Functional Characterization of TREM2 and PLD3
Anonymous Foundation(PI):Exome Sequencing in Alzheimer's Disease Families to Identify Novel Variants Implicated in Disease RI
NIA(Key Personnel):Integrated Alzheimer's Disease Sequence Analysis
Genentech, Inc.(Key Personnel):Identification of Rare Variants Implicated in Alzheimer's Disease (AD) Risk by Next-Generation Sequencing of UNC5C in a Large Series of AD Cases and Controls
NIA(Key Personnel):Use of Endophenotypes in the Search for Alzheimer's Disease Risk Genes
NINDS(Key Personnel):Translational Neuroscientist and The Hope Center
Pfizer Biomedical Research Program(Key Personnel):Neuroinflammation: Potential Role as a Biomarker and Treatment Target for Alzheimer's Disease, Project 3
Barnes-Jewish Hospital Foundation(Key Personnel):Genetics of Brain Repair
Joseph Dougherty, PhD NINDS, R00 (PI): Serotonin, Autism, and investigating cell types for CNS disorders 09/30/09-11/30/13
NIH, R21 (Co-PI): Translation profiling and nanoscale localization of synaptic transcripts12/01/12-11/30/15
NIH, R21 (Co-PI):Tools to enhance study of remak schwann cells 09/30/12-08/31/15
Malinckrodt Foundation (PI):Induction of specific neuronal types from adult fibroblasts 6/11-6/14
Hope Center(Co-PI):Isolating Cell-Type Specific miRNAs from Mice 11/11-11/13
Children's Discovery Institute (Co-PI): Building Tool for Regenerative Medicine to specify and pattern
Pluripotent Neural Crest cells 02/01/13-01/31/16
NARSAD (PI) Independent Investigator Grant 9/15/16-9/14/18
NIMH R01 (PI): Regulation of Mammalian Social Behavior by the GTF2I Family of Proteins 05/01/15-6/30/20
NIDA R21( Co-PI):Using transgenic mice to examine the role of cnih3 variants in opioid dependence 4/1/16-3/31/21
NIMH U01 (Co-PI):An inducible molecular memory system to record transient states of CNS cells9/1/15-8/31/18
NIHGRI R01 (Co-PI): Massively parallel characterization of cis-regulatory elements in the brain 07/01/15-6/30/19
NIDA R21 (PI): Development of a novel approach to study alternative translation in the CNS 07/01/14-06/30/16
Nuri Farber, MD James S. McDonnell Foundation(Significant Contributor):Reconstructing Consciousness and Cognition, Phase 2
NICHD(Significant Contributor):Washington University Intellectual and Developmental Disabilities Research Center
Missouri SCIDRP(Significant Contributor):Anesthesia Induced Apoptosis in the Developing Spinal Cord
NIDDK(Significant Contributor):Targeting Endoplasmic Reticulum for the Treatment of Wolfram Syndrome
ICTS(PI):Maintaining Response to Ketamine in Patients with Major Depression
NICHD(Significant Contributor):Anesthesia Toxicity in Neonatal Primate Brain
Ellen Fitzsimmons-Craft, PhD Missouri Mental Health Foundation(Significant Contributor):Missouri Eating Disorders Council Healthy Body Image Program Project Coordination
Missouri Mental Health Foundation(Significant Contributor):Missouri Eating Disorders Council Ozark Training Program Project Coordination
NIMH(Significant Contributor):Using Technology to Improve Eating Disorders Treatment
NIMH(Significant Contributor):Implementation of Evidence-Based Treatments for On-Campus Eating Disorders
NIMH(Co-I):Investigating the Promotion of Eating Disorders on Twitter: Implications for Online Intervention
Kenneth Freedland, PhD NHLBI(Key Personnel):Omega-3 for Depression and Other Cardiac Risk Factors
NHLBI(PI):Depression and Rehospitalization in Patients with Heart Failure
NHLBI(PI) Stepped Care for Depression in Heart Failure
Michael Gaffrey, PhD Klingenstein Third Generation Foundation Fellowship (PI): Neural circuitry of Preschool Onset Major Depressive Disorder

McDonnell Center for Systems Neuroscience (PI): Functional brain activity and organization in preschool age children with a history of maternal depression

McDonnell Center for Systems Neuroscience (Co-I): Baby on the Brain: Neurobiological mechanisms of caregiving associated with postpartum depression

NIMH K23 (PI): Functional brain network development in early childhood depression

NIMH R01 (PI): Neurodevelopmental trajectories of reward processing in very early emerging risk for depression
Paul Glaser, MD, PhD Simons Foundation Autism Research Initiative(PI):Clinical Site Network for the National Autism Cohort
ICTS(Significant Contributor):Combined Effects of Propranolol and Early Behavioral Intervention on ASD
CDC(Significant Contributor):Metropolitan St. Louis Autism & Developmental Disabilities Surveillance & Epidemiology
CDC(Significant Contributor):Missouri Autism Centers of Excellence Collaborative (MACEC): SEED Early Development Study
Anne Glowinski, MD, MPE NICHD (Co-Investigator): Early quantitative characterization of reciprocal social behavior
CHADS ER Project, Wash U PI
Julia Grant, PhD NIDA(Key Personnel):Cannabis Use, Abuse and Dependence: Exploring Phenotypes
NIAAA(Key Personnel):Molecular Epidemiology of Alcoholism 3 - EDAC Families
NIDA(Key Personnel):Gene Environment in Outcomes of Offspring of Twins with Substance Use Disorders
NIAAA(Key Personnel):Early Alcohol Use Onset: Influence of Religion-Spiritual Dimension
NIAAA(Key Personnel):Offspring of Twins: G, E and GxE Risks for Alcoholism
NIDA(Key Personnel):The Genetics of Vulnerability to Nicotine Addictions
Deanna Greene, PhD NIMH K01 (PI): Predicting outcome in children with tic disorders using neuroimaging data

Intellectual and Developmental Disabilities Research Center (PI): Characterizing the individualized functional connectome in development

Tourette Syndrome Association (PI): Network architecture of the brain in Tourette syndrome and its phenotypic subgroups

McDonnell Center for Systems Neuroscience (PI): Preliminary investigation of motor and cognitive inhibition in children with Tourette syndrome
Richard Grucza, PhD, MPE NIDA(PI): Smoking, Suicide, and Mental Health: Using Policy Change to Probe Causality.

NIDA (MPI): Cannabis, Depression and Suicidal Thoughts and Behaviors.

Oscar Harari, PhD NIA(Key Personnel):Optimizing Combinatorial GWAS of Alzheimer Disease High-throughput Data
NIDA(Significant Contributor):Research Education Program in Aspects of Statistical Genetics and Addiction
NIA(Significant Contributor):Identifying Rare Variants that Increase Risk for Alzheimer's Disease
NIA(Significant Contributor):Using Quantitative Traits to Identify Novel Genes for Alzheimer's Disease and Other Complex Traits
Knight ADRC(PI):Cell-free DNA and RNA as Alzheimer's Disease Diagnostic Tools
NIH(PI):Identification and Characterization of Genetic and Molecular Networks of Alzheimer Disease Pathology
Michael Harms, PhD NICHD(Significant Contributor):Genetics, the Adolescent Brain, and Addiction Liability: A Longitudinal Twin Study
NIMH(Significant Contributor):Neuroimaging in Early Onset Depression: Longitudinal Assessment of Brain Changes
NIMH(Significant Contributor):The Neural Meta-Structure of Psychopathology
Office of the Director(Significant Contributor): Mediators and Moderators of Effects of Environmental Exposures on Neurodevelopment and Health Outcomes in Early Childhood
NIMH(Significant Contributor):Connectomics in Psychiatric Classification
NIAAA(Significant Contributor):Alcohol and the Brain: Leveraging the Human Connectome Project
NIAAA(Significant Contributor):Neuroanatomical Validation of ERP Endophenotypes for Alcoholism
NIDA(Significant Contributor):Test-Retest Reliability of Putative fMRI Endophenotypes for Substance Abuse Risk
NIDA(Significant Contributor):3/13 ABCD-USA Consortium: Twin Research Project
NIA(Significant Contributor):Mapping the Human Connectome During Typical Aging
NIMH(Significant Contributor):Connectome Coordination Facility
NIMH(Significant Contributor):Mapping the Human Connectome During Typical Development
NIMH(Significant Contributor):Neurodevelopmental Trajectories of Reward Processing in Very Early Emerging Risk for Depression
Sarah Hartz, MD, PhD NIDA(PI):Novel Use of GWAS for Improved Understanding of Nicotine Dependence

ICTS(PI):Return of Results in Genetic Studies
Andrew Heath, DPhil NICHD(Key Personnel):Early Quantitative Characterization of Reciprocal Social Behavior
NICHD(Significant Contributor):Genetics, the Adolescent Brain, and Addiction Liability: A Longitudinal Twin Study
NIAAA(Significant Contributor):Outcomes of Recurrent DUI-Moms & Their Children
NIMH(Significant Contributor):The Neural Meta-Structure of Psychopathology
NICHD(Significant Contributor):A Twin Study of Food Addiction
NIAAA(PI):Center on Women and Alcoholism
NIDA(Key Personnel):Cannabis and Tobacco Involvement: A Twin Study
NIAAA(Key Personnel):Age at First Drink and Alcoholism: Intersection of Genes and Environment
NIDDK(Key Personnel):Metagenomic Studies of the Gut Microbiomes of Obese and Lean Twins
NIAAA(PI):Gene-Environment Interplay in Alcoholism
NIAAA(Key Personnel):Neuroanatomical Validation of EEG/ERP Endophenotypes for Alcoholism
NIAAA(Key Personnel):Neighborhood, Family and Individual Factors in Adolescent Drinking
NIH(Significant Contributor):Drug Use in African American Children of Sisters Discordant for Marriage-at-Birth
NIAAA(PI):Novel Screen for Chronic Excessive Alcohol Use
NIAAA(Significant Contributor):Alcohol and the Brain: Leveraging the Human Connectome Project
NIAAA(Significant Contributor):Neuroanatomical Validation of ERP Endophenotypes for Alcoholism
NIAAA(Significant Contributor):Distinctions Between Black and White Young Women in the Course of Alcohol Use
NIDA(Significant Contributor):3/13 ABCD-USA Consortium: Twin Research Project
NIDDK(Key Personnel):Metagenomic Studies of Gut Microbiomes of Obese and Lean Twins - Biospecimen Collection Core A
NIAAA(PI):Biomedical Training in Alcoholism Research
NIMH(Key Personnel):Mapping the Human Connectome: Structure, Function, and Heritability
Tamara Hershey, PhD NICHD (PI): Tracking Neurodegeneration in Early Wolfram Syndrome
NIDDK (PI): Early Predictors of Brain Health and Development in Youth with T1DM
NINDS (PI): Using Diffuse Optical Tomography to Understand Deep Brain Stimulations Impact on Cortical Networks
NIA (Key Personnel): Remediating Age Related Cognitive Decline: Mindfulness-Based Stress Reduction and Exercise
NINDS (Key Personnel): Glucose Metabolism and the Default Mode Network in Health and Disease
NIEHS (Key Personnel): Imaging Biomarkers of Neurotoxicity in Welders
NIEHS (Key Personnel): Motor and Cognitive Health Outcomes in a Mn-Exposed African Community
NICHD (Key Personnel): Type One Diabetes in the Brain in Children: Metabolic Interventions
NICHD (Key Personnel): Ischemic Conditioning as a Neurorecovery Agent for Stroke
Children's Discovery Institute (Key Personnel): Effects of Childhood Malnutrition on Brain Development
Barnes-Jewish Hospital Foundation (Key Personnel): Complex Effects of Dietary Manipulation on Metabolic Function, Inflammation and Health
NIDDK (Key Personnel): Clinical Trial of Dantrolene Sodium in Patients with Wolfram Syndrome
Barry Hong, PhD, ABPP HRSA (Key Personnel): National Living Donor Assistance Center

NIH (Co-Investigator): National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Yukitoshi Izumi, MD, PhD Juvenile Diabetes Research Foundation(Key Personnel):Hypoglycemia-Induced Synaptic Dysfunction in the Developing Brain
NIMH(Key Personnel):Modulation of Hippocampal Synaptic Plasticity
Celeste Karch, PhD NIA:Genetic Disruption of Tau Metabolism in Tauopathies

BrightFocus Foundation:Defining the Role of Phospholipase D3 in Alzheimer's Disease Pathogenesis

McDonnell Center for Cellular and Molecular Neurobiology:The role of MAPT mutations on tau kinetics in a human neuronal model of frontotemporal dementia

Hope Center Pilot: Neuronal subtype-specific vulnerability in tauopathies using reprogramming methods in human somatic and stem cells

Rainwater Charitable Foundation:Observational Study of Familial Frontotemporal Dementia Caused by MAPT Mutations

Rainwater Charitable Foundation(Key Personnel):MAPT A152T/Tauopathy Systems Neuropathology Project

Sara L. Kornfield, PhD PTSD and Pregancy: Psychophysiology, response to treatment & pregnancy outcome
NIH Project #: 5K23MH102360-02

Eric Lenze, MD NCATS(Significant Contributor):Maximizing the Impact of the Multicenter Clinical Trial Enterprise
NIMH(PI):2/3 Buprenorphine for Treatment-resistant Late-life Depression
NIMH(PI):Enhanced Medical Rehabilitation for Older Adults
NIMH(Significant Contributor):2/3 Buprenorphine for Treatment-resistant Late-life Depression
James S. McDonnell Foundation(Significant Contributor):Reconstructing Consciousness and Cognition, Phase 2
NIMH(PI):Mechanisms of Cognitive Decline in Late-Life Anxiety Disorders
Patient-Centered Outcomes Research Institute(PI):Re-engineering Geriatric Post-acute Rehabilitation for Higher Engagement and Higher Intensity
NIMH(Key Personnel):An Efficient Method of Testing Pharmacological Enhancement for Treating Anxiety
NIMH(PI):2/3 Antiglucocorticoid Therapy for Cognitive Dysfunction in Late-life Anxiety
NIH(Significant Contributor):Novel Therapeutics Research Training Program
Food and Drug Administration(Key Personnel):Bioequivalence and Clinical Implications of Generic Bupropion
Barnes-Jewish Hospital Foundation(PI):Fall-related Injury Prevention: Pharmacogenomics to Improve Antidepressant Safety
NIA(Significant Contributor):Self-management to Prevent Falls in Older Adults with Cancer
NIA(Significant Contributor):Electroencephalograph Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES)
NIA(Significant Contributor):Implementation of Home Modifications to Prevent Falls for Older Adults at High Risk
NIA(PI):Remediating Age Related Cognitive Decline: Mindfulness-Based Stress Reduction and Exercise
McDonnell Center for Systems Neuroscience(PI):Functional Connectivity Mechanismsof NMDA Antagonist Treatment for Major Depressive Disorder
NCCIH(PI):Optimizing Interventions to Reverse Stress Effects on the Aging Brain
Patient-Centered Outcomes Research Institute(PI):Optimizing Outcomes in Treatment-Resistant Depression in Older Adults
NCATS(Significant Contributor):The NCATS Clinical Trial Mobile Suite
NIAMSD(Significant Contributor):Molecular Transducers of Physical Activity Adult Clinical Center
NIH(Key Personnel):Mindfulness-Based Stress Reduction on Insomnia for Adults with Chronic Pain due to Rheumatoid Arthritis
Shannon Lenze, PhD NIMH(PI):Perinatal Depression: Dyadic-IPT to Improve Health of Mother and Baby

McDonnell Center for Systems Neuroscience (PI): Baby on the Brain: Neurobiological Mechanisms of Parenting in Postpartum Depression

BJHF/ICTS (PI): Improving Perinatal Depression Outcomes with Mobile Technology
Christina Lessov-Schlaggar, PhD NIMH(Significant Contributor):NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits
NIA(Significant Contributor):Alzheimer's Disease Research Center
NICHD(Significant Contributor):Washington University Intellectual and Developmental Disabilities Research Center
NIDA(Significant Contributor):3/13 ABCD-USA Consortium: Twin Research Project
NINDS(Significant Contributor):Parkinson Disease Clinical Subtypes: Validation, Clinical Utility, and Biological Correlates
Collins Lewis, MD NIMH(Key Personnel):Mapping Abnormal Neurodevelopment in Schizophrenia
NIAAA(Key Personnel):Alcoholism: Epidemiologic High Risk Family Study - MOFAM
NIMH(Key Personnel):Follow-Up of Vietnam Veterans at Risk for Suicide
Joan Luby, MD -Co-P.I. (with Deanna M. Barch Ph.D.)
Developmental Neuroscience and Child Psychopathology 1T32MH100019-01
2013-2018

-Principal Investigator
A Randomized Controlled Trial of PCIT-ED for Preschool Depression
1R01MH098454-01A1
2013-2018

-Principal Investigator (with Deanna Barch, Ph.D.)
Neuroimaging in Early Onset Depression: Longitudinal Assessment of Brain Changes
2R01MH090786-06
2015-2020

Patrick Lustman, PhD NIMH(PI):Improving Depression Treatment Outcomes with an Insulin-Sensitizing Agent
Barnes-Jewish Hospital Foundation(PI):Developing Novel Treatments and Target in Major Depressive Disorder
Pamela Madden, PhD NIDA(PI): The Genetics of Vulnerability to Nicotine Addictions
NIDA(Co-PI): Research Education Program in Aspects of Statistical Genetics and Addiction
NIAAA(Key Personnel): MARC: Risk Mechanisms in Alcoholism and Comorbidity
NIDA(Key Personnel): Cannabis and Other Illicit Drug Use: A Twin Study
NIDA(Key Personnel): Cannabis and Tobacco Involvement: A Twin Study
NIAAA(Key Personnel): Alcohol Use Disorder in Young Women: Genetic Epidemiology: MOAFTS Wave 7
Daniel Mamah, MD, MPE NIMH (PI): Connectomics in Psychiatric Classification
NIMH (PI): Neuromorphometry of Psychosis in Bipolar Disorder
NIMH (PI): Genes, Behavior and Psychosis Risk in Kenya
NIMH (PI): Identification of Psychosis Risk Traits in Africa
McDonnell Center for Systems Neuroscience (PI): Optimizing Brain Connectomics in Psychiatric Disorders
NARSAD (PI): Neuromorphometry of Schizophrenia Spectrum Disorders
Natasha Marrus, MD, PhD McDonnell Center for Systems Neuroscience Grant, “Infant Social Dynamics,” co-Principal Investigator
Jose Mathews, MD NARSAD(PI):Characterizing Human Taste Reward Function diromg Olanzapine Treatment Using fMRI
NIMH(PI):Primary Reward Mechanism Dysfunction in Depression
Kim McCallum, MD Disordered Eating and Health Related Beahviors Pilot Study with Melissa Munn-Chernoff
Vivia McCutcheon, PhD NIAAA (SUNY) (Key Personnel): Collaborative Study on the Genetics of Alcoholism
Steven Mennerick, PhD NIMH(Key Personnel):Oxysterols and NMDAR Function
Sage Therapeutics(PI):In Vitro for NMDA Receptor Encephalitis
NIDA(Key Personnel):Biomedical Research Training in Drug Abuse
NIMH(PI):Neurosteroids and Anxiety Related Network Function
NIMH(PI):Control of Synaptic Glutamate Release
Elliot Nelson, MD NIDA(PI):Using Transgenic Mice to Examine the Role of CHIH3 Variants in Opioid Dependence
NIDA(Co-I) Cannabis, Depression and Suicidal Thoughts and Behaviors
NIAAA(Co-I):Center on Women and Alcoholism

NIDA(PI of Center for Inherited Disease Research Project (CIDR)): A GWAS of Heroin Dependence
NIAAA(PI): Project 7: Examining genotype x environment interaction in the context of a GWAS (P60 Lead PI: A.Heath)
NIDA(PI):Opioid Dependence: Candidate Genes and G x E Effects
NIAAA (& NICHD / NIMH) (PI): Childhood Trauma, Parental Alcoholism, and Comorbidity
Ginger Nicol, MD 1. Co-Principal Investigator, Otuska America funded Investigator Initiated Clinical Trial, Collaborative Protocol Number #031-104-00014: An Open-label, Multi-center, Longitudinal, Within-subject Comparison Study to Evaluate the Effects of Aripiprazole Once Monthly in Subjects with Schizophrenia on 30-, 90- and 180-day Re-hospitalization Rates Following Hospital Discharge Compared with Retrospective Re-hospitalization Rates while on Oral Antipsychotic Medication
2. Consultant (PI: Zohreh Talebizadeh, PhD) Patient-Centered Outcomes Research Institute (PCORI); Incorporating Genetic Data in PCOR studies: Building a Roadmap for Stakeholder Engagement
Kevin Noguchi, PhD R01 NICHD (PI): Anesthesia toxicity in neonatal primate brain

R01 NICHD Administrative Supplement (PI): Anesthesia toxicity in neonatal primate brain

R01 NICHD (Key Personnel): Hypothermia to prevent neurotoxic side effects of pediatric drugs

U54 NICHD (Neuropathology Unit: Core Faculty): Washington University Intellectual And Developmental Disabilities Research Center
Rumi Kato Price, PhD, MPE DoD DMRDP (PI): Family as a Total Package (FAMPAC): Restoring and Enhancing Psychological Health of Citizen Soldiers.

Washington University Institute for Public Health (PI): Human trafficking in the St. Louis Metropolitan Area

DoJ/OJJDP (consortium PI): St. Louis Girls At Risk Initiative.

Washington University Institute for Public Health/Center for Dissemination and Implementation (PI): Feasibility and Acceptability of a Sensor-assisted E-therapy for PTSD
John Pruett, Jr., MD, PhD ACTIVE:

R01 MH093510 (NIMH) (Pruett, PI) 4/17/12-1/31/18
"fcMRI in Infants at High Risk for Autism"
This study will test the altered brain functional connectivity hypothesis of autism during infancy.
Role: PI

R01 HD055741 (NICHD) (Piven, PI) 9/4/12-5/31/17
“A Longitudinal MRI Study of Infants at Risk for Autism” (fcMRI Imaging Processing Core)
This study is a competing continuation of an Autism Center of Excellence (ACE) Network grant supporting a prospective, longitudinal examination of brain and behavior at 6, 12 and 24 months in infants at high familial risk (HR) for autism.
Role: (fcMRI Imaging Processing Core) Sub-Contract PI

1 U54 HD087011-01 (NICHD) (Constantino and Schlaggar, Co-PIs) 9/18/15 – 5/31/20
“Sex-Specific Modulation of ASD Liability: Compensatory Mechanisms and Recurrence”
The Intellectual and Developmental Disabilities Research Center at the Washington University School of Medicine is a scientific program composed of three core facilities, one dedicated to studies of cellular and molecular mechanisms of causation in IDD, one dedicated to the identification of “signatures” of developmental disability that can be imaged in the developing brain, and one dedicated to in-depth clinical assessment of human subjects and the translation of new understanding of causal mechanisms into higher impact intervention.
Role: Co-Investigator

WUIDDRC Pilot Fund (Pruett, PI) 5/27/16 – 5/26/17
“Toddler social motivation and communication”
The scientific objective of this study is to correlate dimensional measures of joint attention with ASD-relevant abilities.
Role: PI

The Drs. John R. (Sr.) and Patricia O. Pruett Fund for research in social cognition and for undergraduate training

The Azrieli Neurodevelopmental Research Program/ Brain Canada Multi-Investigator Research Initiative (A. Evans, PI) 4/1/14-3/31/19 "Structural and Functional Networks in Autism Spectrum Disorder and Fragile X Syndrome"
Role: Mentor/Collaborator

R01 MH104543 (NIMH) (L. Parr, PI)
"Effects of Oxytocin on Brain, Behavior, and Development" 5/1/15-4/30/20.
This project will examine the effects of repeated oxytocin administration on social behavior and neural development in infant monkeys as a first step towards understanding how this hormone modulates social behavior.
Role: Consultant
Alex Ramsey, PhD NIDA (K12 Scholar): Washington University Career Development Program in Drug Abuse and Addiction

Foundation for Barnes-Jewish Hospital (PI): Reducing Disparities in Hospital Prescribing of Smoking Cessation Pharmacotherapy

PCORI (Collaborator): Optimizing Outcomes in Treatment-Resistant Depression in Older Adults

Washington University Institute for Public Health, Center for Dissemination and Implementation (PI): Unpacking Successful Implementation of Electronic Screening and Brief Intervention
Angela Reiersen, MD NIMH(Significant Contributor):Molecular Basis of Selected GxE Effects in Combined Type ADHD
John Rice, PhD NIMH (PI): Research Training in Clinical Sciences

NIDA (Key Personnel): The Genetics of Vulnerability to Nicotine Addictions

NIMH (Key Personnel): NIMH Center for Collaborative Genetic Studies

NIDA (Key Personnel): Case Control Candidate Gene Study of Addiction

NCI (Key Personnel): The Collaborative Genetic Study of Nicotine Dependence

NIDA (Key Personnel): NIDA Center for Genetic Studies

NIAAA (Key Personnel): Collaborative Study on the Genetics of Alcoholism (COGA)

NIDA (Key Personnel): Research Education Program in Aspects of Statistical Genetics and Addiction
Cheryl Richards, PhD Tourette Syndrome Association(PI):Testing a Pathophysiological Model of Complex Tics
Brain and Behavior Research Foundation(Significant Contributor):MRI Studies Testing Hypotheses about How Behavior Therapy Works in Tic Disorders
Cynthia Rogers, MD t

NIMH(PI):Predicting Preschool Psychopathology with Brain Connectivity in Preterm Neonates

Steward Family(PI):Perinatal Behavioral Health Service

Maternal, Child & Family Health Coalition(PI):Washington University Perinatal Behavioral Health Service
Maternal, Child & Family Health Coalition(PI):The Washington University-PBHI-Psychiatric Training and Consultation

Doris Duke Charitable Foundation(PI):Doris Duke Fund to Retain Clinical Scientists (DDFRCS)
John Rohrbaugh, PhD U.S. Army(PI):Physiological Measurement Using Laser Doppler Vibrometry - TSWG Task IS-ST-3319
Department of Defense(PI):IR LDV SYSTEM 001 588/0002/10
Eugene Rubin, MD, PhD NIA(Key Personnel):Dominantly Inherited Alzheimer's Network Trial: An Opportunity to Prevent Dementia
NIA(Significant Contributor):Alzheimer's Disease Research Center
NHLBI(Key Personnel):Omega-3 for Depression and Other Cardiac Risk Factors
NIA(Significant Contributor):Healthy Aging and Senile Dementia
NHLBI(Significant Contributor):Stepped Care for Depression in Heart Failure
Scott Saccone, PhD NIDA (PI): Design and Interpretation of SNP Association Studies of Addiction
ACS (PI): Identifying Genetic Risk Loci for Nicotine Dependence
NCI (Key Personnel): The Collaborative Genetic Study of Nicotine Dependence
NIMH (Key Personnel): NIMH Center for Collaborative Genetic Studies - Data Analysis
NIDA (Key Personnel): The Genetics of Vulnerability to Nicotine Addictions
NIAAA (SUNY)(Key Personnel): Collaborative Study on the Genetics of Alcoholism
NIDA (Key Personnel): Case Control Candidate Gene Study of Addiction
NIDA (Key Personnel): NIDA Center for Genetic Studies
Dragan Svrakic, PhD, MD NIMH(Key Personnel):Molecular Genetics of Schizophrenia

VAST D study of refractory depression
Mini Tandon, DO NIDA/K12/AACAP DA000357 (PI) Prenatal Cigarette Exposure and Course of Childhood ADHD. 2010
Alexandre Todorov, PhD NIAAA(Key Personnel):Molecular Epidemiology of Alcoholism 2 - Big Sibships
NIDA(Key Personnel):Cannabis Use, Abuse and Dependence: Exploring Phenotypes
NIAAA(Key Personnel):Midwest Alcoholism Research Center: Genetic Epidemiology of Alcoholism & Comorbidity
NIDA(PI):Genetic Epidemiology of Opioid Dependence in Bulgaria
NIDA(Key Personnel):Genetic Studies of Substance Abuse in Iowa Adoptees
NICHD(Key Personnel):Autistic Traits: Life Course & Genetic Structure
NIMH(PI):Molecular Basis of Selected GxE Effects in Combined Type ADHD
NIMH(Key Personnel):2/5 The Psychiatric GWAS Consortium: Integrated & Coordinated GWAS Meta-Analysis
NIMH(Key Personnel):Molecular Genetics of Inattention in Australia
NIDA(Key Personnel):Prenatal Tobacco Exposure: Effects on Neuropsychological Outcomes and ADHD
Jen-Chyong Wang, PhD NIAAA (SUNY)(Key Personnel):Collaborative Study on the Genetics of Alcoholism
NIDA(Key Personnel):Case Control Candidate Gene Study of Addiction
NIDA(Key Personnel):The Genetics of Vulnerability to Nicotine Addictions
Robinson Welch, PhD NIMH(Key Personnel):Family Therapy and Fluoxetine in the Treatment of Adolescent Anorexia Nervosa
NIDDK(Key Personnel):Statistics Center for Pediatric Type 2 Diabetes Therapy - Clinical Performance Site
Denise Wilfley, PhD NHLBI 1T32HL130357-01 (PI)
WUSTL Transdisciplinary Pre- and Postdoctoral Training Program in Obesity and Cardiovascular Disease

NHLBI 5U01HL131552-02 (Co-PI)
The Effectiveness of Family-based Weight Loss Treatment Implemented in Primary Care

AHRQ 1R13HS022816 (PI)
Evidence-based Childhood Obesity Treatment: Improving Access to Systems of Care

NHLBI 2 T32 HL007456-26 (PI)
Nutrition-Behavioral Cardiovascular Disease Prevention

NIMH 1R01MH095748-01 (PI)
Implementation of Evidence-based Treatments for On-campus Eating Disorders

NIMH 1R01MH100455-01 (PI)
Using Technology to Improve Eating Disorders Treatment

NICHD 2 R01 HD036904-06 (PI)
Childhood Obesity Treatment: A Maintenance Approach

NIDDK 1 U01 DK61230 (Subcontract PI)
Studies to Treat or Prevent Type 2 Diabetes in Adolescents & Youth

NIDDK 1R01DK104115-01 (Co-I)
Preventing Obesity in Military Communities – Adolescents

NICHD R01HD080292-01 (Co-I)
Using Prospection to Improve Obesity Treatment

National Eating Disorders Association (PI)
Harnessing Technology for Training Clinicians to Deliver Interpersonal Psychotherapy

Shire Pharmaceuticals (PI)
Training in Interpersonal Psychotherapy (IPT) to Treat Binge Eating Disorder

General Mills Champions for Healthy Kids Grant (PI)
KIPP Victory Academy Healthy Habits Program

Norwegian Regional Health Authorities (Co-I)
Treatment of Severely Obese Children and Adolescents in Common Health Care Settings: An Effectiveness Study Employing Family based Behavioral Social Facilitation Treatment (FBFST)
Fay Womer, MD NIMH(PI):Structure and Function of the Cerebellar Vermis Across Schizophrenia Bipolar Disorder and Major Depressive Disorder
David Wozniak, PhD NINDS(Key Personnel):Pathophysiology and Novel Therapies for Batten's Disease
NICHD(Key Personnel):Washington University Intellectual and Developmental Disabilities Research Center (Co-Director, Core E: Animal Models Core (AMC); Director: Behavior Subcore of AMC)
NINDS(Key Personnel): Optical Imaging and Functional Connectivity Mapping in Mice.
NINDS (Key Personnel): Mechanisms of Seizure-Induced Dendritic Injury.
NINDS (Key Personnel): Influence of Interhemispheric Connectivity on Recovery of Focal Ischemia
NINDS (Key Personnel): Novel Therapies for Globoid-Cell Leukodystrophy
NINDS (Key Personnel): The Role of BK Channels in Neuropathology of Fragile X Syndrome
Charles Zorumski, MD NIMH(co-PI):Oxysterols and NMDAR Function