Associate Professor of Psychiatry
Areas of Research Interests
My research is concerned with genetic and neurobiological bases of human individual differences, including personality and psychopathology. I am particularly interested in behavioral traits that are associated with increased vulnerability to addictive disorders. A major theoretical premise of my work is that genetic influences on complex behaviors are mediated by variability in brain function. Therefore, the overall goal of my studies is to understand genes-brain-behavior relationships through the combination of genetic, neurocognitive, developmental, and psychological assessment methods. More specific goal is to identify "endophenotypes" for substance use disorders and associated deficits of behavioral self-regulation such as poor inhibitory control, decision making, and action monitoring. In addition, we are interested how alcohol and/or nicotine use (both acute and long-term) affects these "executive" functions.
Our research participants include twins, as well as non-twin volunteers. Assessment methods include 1) electroencephalogram (EEG) and event-related brain potentials (ERPs) recorded in a variety of experimental paradigms, such as visual oddball, Go/No-Go, attention tests, "gambling" experiment, flanker interference task, sensory gating, and affective pictures; 2) neuropsychological and behavioral tests, including card sorting, decision making, and risk taking; 3) psychological and psychiatric assessments including personality questionnaires and semi-structured diagnostic interviews. My lab is equipped for designing and conducting computer-based neuropsychological testing and behavioral experiments (STIM system), multi-channel acquisition and analysis of psychophysiological data (SCAN system, Neuroscan Labs), as well as for the measurements of breath alcohol, carbon monoxide, and collection of blood samples for genotyping.
Anokhin AP, Heath AC, Myers E: Genetics, prefrontal cortex, and cognitive control: a twin study of event-related potentials in a response inhibition task. Neuroscience Letters 2004; 368:314-318.
Anokhin AP, Muller V, Lindenberger U, Heath AC, Myers E: Genetic influences on dynamic complexity of brain oscillations. Neurosci Lett 2006; 397(1-2), 93-98.
Anokhin AP, Vedeniapin AB, Sirevaag EJ, Bauer LO, O'Connor S, Kuperman S, Porjesz B, Reich T, Begleiter H, Polich J, Rohrbaugh JW: The P300 brain potential is reduced in smokers. Psychopharmacology 2000; 149:409-413.
Anokhin AP, van Baal GCM, van Beijsterveldt CEM, de Geuss EJC, Grant J, Boomsma DI: Genetic correlation between P300 event-related brain potential and EEG power spectrum. Behavior Genetics 2001; 31:545-554.
Anokhin AP, Lutzenberger W, Birbaumer N: Spatiotemporal organization of brain dynamics and intelligence: An EEG study in adolescents. International Journal of Psychophysiology 1999; 33:259-273.
Funded Research Projects
NIAAA(PI):College Drinking: A Twin Study
NIDA(PI):Neurocognition, Genetics, and Adolescent Substance Abuse
NIAAA(PI):Neurocognitive Consequences of Underage Drinking
NICHD(Key Personnel):Autistic Traits: Life Course and Genetic Structure