Return to the Faculty List
John Rice, PhD
Current
Position
Professor of Mathematics in Psychiatry
Education and Training
PI of NIMH T32 Training Grant
CO-PI of NIDA R25 Training Grant
Areas of Research Interests
Current research interests in my lab include method development in genetic epidemiology and the collection and analysis of family and population data on bipolar disorder, major depression, schizophrenia and substance abuse. Methodologic work includes: (i) the development of new measures of linkage disequilibrium to define SNPs for association analysis; (ii) assessing the accuracy of imputation; and (iii) developing statistical methods to assess CNV (copy number variation) prediction. I continue to apply these new techniques to a number of currently existing data sets. My emphasis has been shifting from linkage analysis using several hundred repeat markers to association analysis using 1 million SNPs in GWAS (Genome-wide Association Studies). This new trend in the genetics of complex traits represents many challenges in data management and in analysis. My lab also maintains the phenotypic component of the genetic repository for NIMH, NIDA and NIAAA. Future emphasis will be the use of statistical genetics and bioinformatics for the meta-analysis of the genetic data available.
Key Publications
Pinto D, Pagnamenta AT, Klei L, Anney R, Merico D, Regan R, Conroy J, Magalhaes TR, Correia C, Abrahams BS, Almeida J, Bacchelli E, Bader GD, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bölte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Bryson SE, Carson AR, Casallo G…Rice JP et al. Functional impact of global rare copy number variation in autism spectrum disorders. Nature 2010 Jun 9. PMID: 20531469 Full Article ->
Sanders AR, Levinson DF, Duan J, Dennis JM, Li R, Kendler KS, Rice JP, Shi J, Mowry BJ, Amin F, Silverman JM, Buccola NG, Byerley WF, Black DW, Freedman R, Cloninger CR, Gejman PV. The Internet-Based MGS2 Control Sample: Self Report of Mental Illness. Am J Psychiatry 2010 Jun 1. PMID: 20516154 Full Article ->
Sanders AR, Duan J, Levinson DF, Shi J, He D, Hou C, Burrell GJ, Rice JP, Nertney DA, Olincy A, Rozic P, Vinogradov S, Buccola NG, Mowry BJ, Freedman R, Amin F, Black DW, Silverman JM, Byerley WF, Crowe RR, Cloninger CR, Martinez M, Gejman PV (2008 Apr). No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. Am J Psychiatry. 165(4): 497-506. Full Article ->
Hartz SM, Lin P, Edenberg HJ, Xuei X, Rochberg N, Saccone S, Berrettini W, Nelson E, Nurnberger J, Bierut LJ, Rice JP. Genetic association of bipolar disorder with the ß3 nicotinic receptor subunit gene. Psychiatr Genet 2010 Dec 28 (in press). PMID: 21191315 Full Article ->
Elks CE, Perry JR, Sulem P, Chasman DI, Franceschini N, He C, Lunetta KL, Visser JA, Byrne EM, Cousimer DL, Gudbjartsson DF, Esko T, Feenstra B, Hottenga JJ, Koller DL, Kutalik Z, Lin P, Mangino M, Marongiu M, McArdle PF, Smith AV, Stolk L, van Wingerden SH, Zhao JH, Albrecht E, Corre T, Ingelsson E, Hayward C, Magnusson PK, Smith EN, Ulivi S, WarringtonNM, Zgaga L, Alavere H, Amin N…Rice JP, et al. Thirty new loci for age at menarche indentified by a meta-analysis of genome-wide association studies. Nat Genet 2010; 42(12):1077-1085. PMID: 21102462 Full Article ->
Lin P, Hartz SM, Zhang Z, Saccone SF, Wang J, Tischfield JA, Edenburg HJ, Kramer JR, Goate AM, Bierut LJ, Rice JP; COGA Collaborators COGEND Collaborators, GENEVA. A new statistic to evaluate imputation reliability. PLoS One 2010; 5(3):e9697. PMCID: PMC2837741 Full Article ->
Funded Research Projects
NIMH (PI): Research Training in Clinical Sciences
NIDA (Key Personnel): The Genetics of Vulnerability to Nicotine Addictions
NCRR (Key Personnel): Washington University Institute of Clinical and Translational Sciences - Biomedical Informatics (Nagarajan, PI)
NHGRI (Key Personnel): NHGRI EpiGenVar Coordinating Center
NIMH (Key Personnel): NIMH Center for Collaborative Genetic Studies
NIDA (Key Personnel): Case Control Candidate Gene Study of Addiction
NIAAA (Key Personnel): Alcohol Dependence in African-Americans: A Case-Control Genetic Study
NCI (Key Personnel): The Collaborative Genetic Study of Nicotine Dependence
NIDA (Key Personnel): NIDA Center for Genetic Studies
NIAAA (Key Personnel): Collaborative Study on the Genetics of Alcoholism (COGA)
NIDA (Key Personnel): Human Genetic Variation in Smoking and Addiction Risk
NIDA (Key Personnel): Research Education Program in Aspects of Statistical Genetics and Addiction