Professor of Psychiatry
Director of geriatrics rotation for PGY2 psychiatry residents
Education and Training
M.D.: Washington University School of Medicine, 1994
Psychiatry Residency: Washington University School of Medicine, 1998
Geriatric Psychiatry Fellowship: University of Pittsburgh School of Medicine, 1999
Areas of Research Interests
My main research focus is developing and testing treatments for depression and anxiety in older adults.
My expertise is in clinical trials and clinical observational research; my work includes gene-environment interactions, pharmacogenetics and other predictors of response, neuroendocrinology, neuropsychology, pharmacotherapy, cognitive behavioral therapy, and medical rehabilitation.
Lenze EJ, Rollman BL, Shear MK, Dew MA, Pollock BG, Ciliberti C, Costantino M, Snyder S, Shi P, Spitznagel E, Andreescu C, Butters MA, Reynolds CF 3rd (2009 Jan 21). Escitalopram for older adults with generalized anxiety disorder: a randomized controlled trial. JAMA. 301(3): 295-303. Full Article ->
Lenze EJ, Wetherell JL. Bringing the bedside to the bench, and then to the community: a prospectus for intervention research in late-life anxiety disorders. Int J Geriatr Psychiatry. 2009 Jan;24(1):1-14.
Full Article ->
Lenze EJ, Sheffrin M, Driscoll HC, Mulsant BH, Pollock BG, Dew MA, Lotrich F, Devlin B, Bies R, Reynolds CF 3rd. Incomplete response in late-life depression: getting to remission.
Dialogues Clin Neurosci. 2008;10(4):419-30.
Lenze EJ, Munin MC, Skidmore ER, Dew MA, Rogers JC, Whyte EM, Quear T, Begley A, Reynolds CF 3rd (2007 Jan). Onset of depression in elderly persons after hip fracture: implications for prevention and early intervention of late-life depression. J Am Geriatr Soc. 55(1): 81-6. Full Article ->
Whyte EM, Lenze EJ, Butters M, Skidmore E, Koenig K, Dew MA, Penrod L, Mulsant BH, Pollock BG, Cabacungan L, Reynolds CF 3rd, Munin MC. An open-label pilot study of acetylcholinesterase inhibitors to promote functional recovery in elderly cognitively impaired stroke patients.
Cerebrovasc Dis. 2008;26(3):317-21.
Lenze EJ, Munin MC, Ferrell RE, Pollock BG, Skidmore E, Lotrich F, Rogers JC, Quear T, Houck P, Reynolds CF 3rd (2005 May). Association of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fracture. Am J Geriatr Psychiatry. 13(5): 428-32.
Funded Research Projects
NIMH(PI):Risk Genes for Late-Life Depression after Hip Fracture
NIMH(Key Personnel):CBT Augmentation of SSRI Treatment for Geriatric GAD
NIMH(Key Personnel):Improving Quality of Primary Care for Anxiety Disorders
NIMH(PI):Pharmacotherapy of Latelife Generalized Anxiety Disorder
NIMH(Key Personnel):fMRI Studies of Emotional Circuitry in Depression