Reference Number: 201101790
The purpose of the study is to help understand why adding aripiprazole (a type of antidepressant) combined with another antidepressant is effective in people who have treatment resistant depression.
1. Volunteers must be nonsmokers, age 18-55
2. Volunteers must have not responded to at least one previous antidepressant
3. Volunteers must not have schizophrenia, bipolar disorder, or anxiety disorder
Duration: The study will last 18 weeks including follow-up. There will be 10 outpatient visits. Eight of the ten visits will last 60-90 minutes, the other two visits will last about 6 hours.
Tests/Procedures: Blood tests, urine drug screen, ECG, psychological assessments, 2 MRIs and 4 PET scans.
Risks: Risks will be discussed with volunteers as part of the informed consent process.
Benefits: All antidepressant medication will be provided at no cost to qualified volunteers for 16 weeks.
Compensation: Up to $550 is provided for time and effort.
Charles Conway, MD
Washington University School of Medicine
Martha Cornell at 314-362-0038