Professor of Mathematics in Psychiatry
1) Genetic epidemiology of psychiatry disorders, particularly affective disorders and alcoholism.
2) Statistical methodology, particularly logistic regression and survival analysis.
3) Methods for linkage analysis and linkage disequilibrium mapping.
Specific Research Activities
I have focused on the use of covariates in an affective sib pair linkage design to model levels of diagnosis, comorbid disorders, and candidate gene genotypes. I am also involved with SNP (single nucleotide polymorphism) genotyping and working on the problem of construction a LD (linkage disequilibrium) map in humans.
I am actively involved in analyses of the genetics of alcoholism, bipolar disorder and nicotine dependence.
Special Research Activities
The Collaborative Depression Study consists of data on approximately 1,000 probands currently being followed for 15-20 years and 2,500 of their first degree relatives who were personally interviewed.
I am Head of the Data Management Committee for COGA (Collaborative Study on the Genetics of Alcoholism) and have contracts to manage publicly available genetic data for NIMH and NIDA.
Judd LL, Akiskal HK, Maser JD, Rice JP, et al: A Prospective 12 Years Study of Subsyndromal and Syndromal Depressive Symptoms in Unipolar Depressive Disorders. Arch Gen Psychiatry 1998; 55:694-700.
Rice JP, Rochberg N, Neuman RJ, Saccone NL, Kiu K-Y, et al: Covariates in Likage Analysis. Genetic Epidemiology 1999; 17:S691-S695.
Foroud T, Edenberg HJ, Goate A, Rice J, et al: Alcoholism Susceptibility Loci: Confirmation Studies in a Replicate Sample and Further Mapping. Alcoholism: Clinical and Experimental Research 2000; 24(7):933-945.
Taillon-Miller P, Bauer-Sardina I, Saccone NL, Puetzel J, Laitinen T, Cao A, Kere J, Pilia G, Rice JP, Kwak PY: Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28. Nature Genetics 2000; 25:324-328.
Rice J: Diagnosis as a Covariate in Sib-Pair Linkage Analysis. Am J Med Genetics 2001; 105:55-56.
Rice JP, Saccone NL, Suarez BK: The Design of Studies for Investigating Linkage and Association. Analysis of Multifunctional Diseases 37-62.
Rice JP, Saccone NL, Corbett J: The LOD Score Method. Advances in Genetics 2001; 42:99-113.
Rice JP, Saccone NL, Rasmussen E: Definition of a Phenotype. Advances in Genetics 2001; 42:69-76.