Professor of Psychiatry (Child) and Radiology
Professor of Psychiatry (Child) and Radiology
Education and Training
B.A.: Psychology, University of Kansas, Lawrence, Kansas, 1984
Medical Degree: University Of Kansas School of Medicine, Kansas City, KS, 1988
Residency: Psychiatry, Washington University School of Medicine, St. Louis, MO, 1991
Fellowship: Child Psychiatry, Washington University School of Medicine at St. Louis Children's Hospital, 1993
Peer selected for inclusion in St. Louis's Best Doctors, 1999-2005
Presidential Early Career Award for Scientists and Engineers; Executive Office of the President of the United States, 2001
Selected by NIH program staff to speak at the annual K Awardee meeting (Neuroscience Career Development Workshop) as a mentor for successful transition from K Award to independent funding (one investigator, selected annually), 2001
Kansas State University Dean's Scholar Scholarship, 1980
Betty Wahlstedt Memorial Scholarship - for outstanding achievement and academic promise in Anthropology, Psychology or Sociology, 1984
Areas of Clinical Interest
Child and adolescent psychiatry, early onset depression, schizophrenia, obsessive compulsive disorder, Tourette's disorder, bipolar affective disorder, autism, pervasive developmental disorder, neuropsychiatry
Areas of Research Interests
My research investigates structural brain differences in children and adolescents with affective disorders, attention deficit disorder and autism. Additionally, we are examining structural MRI differences in discordant twin populations. We are involved in a longitudinal study to characterize very early brain development with MRI in infants at risk for developing autism and infants with Fragile X. In addition, in order to better understand structural abnormalities which we and others are demonstrating in children with psychiatric disorders, we are seeking to better characterize the progress of normal structural development and associated cognitive & behavioral development, by MRI, in healthy control populations. This research is done in collaboration with Robert McKinstry, M.D., Ph.D (Radiology), Joan Luby, M.D. (Psychiatry), John R. Pruett, M.D., Ph.D. (Psychiatry), Deanna Barch, Ph.D. (Psychology), John N. Constantino, MD (Psychiatry, Pediatrics), Alex Todorov, Ph.D. (Psychiatry), and David Van Essen, Ph.D. (Anatomy).
Secondary to ongoing neurodevelopmental changes, image analysis methodologies need specific validation and potential modifications for use in child populations. We are involved with Dr. Michael Miller and Dr. Tilak Ratnanather’s lab (Johns Hopkins University) on the application of newer image analysis techniques, including automated 3-D, high resolution, warping atlases for child and adolescent populations.
Luby JL, Barch DM, Belden A, Gaffrey MS, Tillman R, Babb C, Nishino T, Suzuki H, Botteron KN (2012 Feb 21). Maternal support in early childhood predicts larger hippocampal volumes at school age. Proc Natl Acad Sci U S A. 109(8): 2854-9. Full Article ->
Wolff JJ, Gu H, Gerig G, Elison JT, Styner M, Gouttard S, Botteron KN, Dager SR, Dawson G, Estes AM, Evans AC, Hazlett HC, Kostopoulos P, McKinstry RC, Paterson SJ, Schultz RT, Zwaigenbaum L, Piven J, the IBIS Network (2012 Jun 1). Differences in White Matter Fiber Tract Development Present From 6 to 24 Months in Infants With Autism. Am J Psychiatry. 169(6): 589-600. Full Article ->
Ducharme S, Hudziak JJ, Botteron KN, Ganjavi H, Lepage C, Collins DL, Albaugh MD, Evans AC, Karama S, Brain Development Cooperative Group (2011 Aug 1). Right anterior cingulate cortical thickness and bilateral striatal volume correlate with child behavior checklist aggressive behavior scores in healthy children. Biol Psychiatry. 70(3): 283-90. Full Article ->
Brain Development Cooperative Group (2012 Jan). Total and regional brain volumes in a population-based normative sample from 4 to 18 years: the NIH MRI Study of Normal Brain Development. Cereb Cortex. 22(1): 1-12. Full Article ->
Gaffrey MS, Luby JL, Repovš G, Belden AC, Botteron KN, Luking KR, Barch DM.Subgenual cingulate connectivity in children with a history of preschool-depression. Neuroreport. 2010 Dec 29;21(18):1182-8.
Munn MA, Alexopoulos J, Nishino T, Babb CM, Flake LA, Singer T, Ratnanather JT, Huang H, Todd RD, Miller MI, Botteron KN (2007 Sep 1). Amygdala volume analysis in female twins with major depression. Biol Psychiatry. 62(5): 415-22. Full Article ->
Funded Research Projects
NIMH (PI):Neuroimaging in Early Onset Depression: Longitudinal Assessment of Brain Changes
NICHD(Key Personnel):A Longitudinal MRI Study of Infants at Risk for Autism
NIMH(Key Personnel):3D Shape Analysis for Computational Anatomy
NICHD(Key Personnel):A Longitudinal MRI Study of Brain Development in Infants with Fragile X Syndrome
NIMH(PI):Novel Cortical Limbic Analysis in Twins Discordant for ADHD
NIH(Key Personnel):IBIS-EARLI Collaboration "Collaboration Risk and Outcome Scientific Study (CROSS)"
NIMH(Key Personnel):Neuroimaging in Early Onset Depression: Longitudinal Assessment of Brain Changes