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John Rice, PhD
Current
Position
Professor of Mathematics in Psychiatry
Education and Training
PI of NIMH T32 Training Grant
Areas of Research Interests
Dr. Rice's current research interests include methods development in genetic epidemiology and family study techniques, and the collection and analysis of family data on the affective disorders, schizophrenia, smoking, alcoholism and other substance-use disorders.
He is the PI in St. Louis for the Collaborative Depression Study (CDS) a five-site study which began in 1978 to collectively follow 955 probands with affective disorders and to assess 612 of their families. He has numerous publications from the CDS data. He is also PI on a multi-site case-control study of Bipolar Disorder. He is a co-investigator on studies of schizophrenia, alcohol dependence and nicotine dependence.
Another area of expertise is in the management and analysis of data from genetic repositories. Dr. Rice maintains the genetic database for the NIMH and NIDA Centers for Genetic Studies. The NIMH repository has existing genetic data on Bipolar Disorder, Schizophrenia, Autism, Major Depression and Alzheimer disease, and these existing datasets are housed in St. Louis. He also distributes the COGA data to other investigators.
Dr. Rice is CO-PI of a GEI project for a Genome-wide Association Study (GWAS) of addiction(PI, Dr. Laura Bierut). This is a case control study with one million SNPs.
Key Publications
Bierut LJ, Madden PAF, Breslau N, Johnson EO, Hatsukami D, Pomerleau OF, Swan GE, Rutter J, Bertelsen S, Fox L, Fugman D, Goate AM, Hinrichs AL, Konvicka K, Martin NG, Montgomery GW, Saccone NL, Saccone SF, Wang JC, Chase GA, Rice JP, Ballinger DG: Novel genes identified in a high-density genome wide association study for nicotine dependence. Hum Mol Genet 2007; 16(1):24-35.
Saccone SF, Hinrichs AL, Saccone NL, Chase GA, Konvicka K, Madden PAF, Breslau N, Johnson EO, Hatsukami D, Pomerleau O, Swan GE, Goate AM, Rutter J, Bertelsen S, Fox L, Fugman D, Martin NG, Montgomery GW, Wang JC, Ballinger DG, Rice JP, Bierut LJ: Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum Mol Genet 2007; 16(1):36-49.
Sanders AR, Duan J, Levinson DF, Shi J, He D, Hou C, Burrell GJ, Rice JP, Nertney DA, Olincy A, Rozic P, Vinogradov S, Buccola NG, Mowry BJ, Freedman R, Amin F, Black DW, Silverman JM, Byerley WF, Crowe RR, Cloninger CR, Martinez M, Gejman PV: No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. Am J Psychiatry 2008; 165(4):497-506.
NCI-NHGRI Working Group on Replication in Association Studies, Chanock SJ, Manolio T, Boehnke E, Hunter DJ, Thomas G, Hirschhorn JN, Abecasis G, Altshuler D, Bailey-Wilson JE, Brooks LD, Cardon LR, Daly M, Donnelly P, Fraumeni Jr. JF, Freimer NB, Gerhard DS, Gunter C, Guttmacher AE, Guyer MS, Harris EL, Hoh J, Hoover R, Kong CA, Merikangas KR, Morton CC, Palmer LJ, Phimister EG, Rice JP, Roberts J, Rotimi C, Tucker MA, Vogan KJ, Wacholder S, Wijsman EM, Winn DM, Collins FS: Replicating genotype-phenotype associations: What constitutes replication of a genotype-phenotype association, and how best can it be achieved?. Nature 2007; 447(7145):655-660.
Payne JL, Mackinnon DF, Mondimore FM, McInnis MG, Schweizer B, Zamoiski RB, McMahon FJ, Nurnberger JI Jr, Rice JP, Scheftner W, Coryell W, Berrettini WH, Kelsoe JR, Byerley W, Gershon ES, Raymond Depaulo J Jr, Potash JB: Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees. Bipolar Disord 2008; 10(1):38-44.
Grucza RA, Bucholz KK, Rice JP, Bierut LJ: Secular trends in the lifetime prevalence of alcohol dependence in the United States: a re-evaluation. Alcohol Clin Exp Res 2008; 32(5):763-770.
Funded Research Projects
NIMH(PI):Collaborative Depression Study
NIMH(Key Personnel):NIMH Center for Collaborative Genetic Studies - Data Analysis
NIAAA (SUNY)(Key Personnel):Collaborative Study on the Genetics of Alcoholism
NIMH(PI):A Collaborative Genomic Study of Bipolar Disorder
NIMH(PI):Research Training in Clinical Sciences
NIDA(Key Personnel):Candidate Genes for Smoking in Related and Unrelated Individuals
NIDA(Key Personnel):NIDA Center for Genetic Studies
NIDA(Key Personnel):The Genetics of Vulnerability to Nicotine Addictions
NINDS(Key Personnel):Washington University Center for Translational Neuroscience (Core F)
NCRR(Key Personnel):Washington University Institute of Clinical and Translational Sciences - Biomedical Informatics (Nagarajan, PI)
NHGRI(Key Personnel):Study of Addiction: Genetics and Environment
NIDA(Key Personnel):Case Control Candidate Gene Study of Addiction
NCI(Key Personnel):The Collaborative Genetic Study of Nicotine Dependence