Brian K. Suarez, PhD
Professor of Psychiatry
Departments of Psychiatry and Genetics
Areas of Research Interests
My long term research interest continues to be the development and testing of quantitative methods to assess the transmission of complex phenotypes. These efforts are aimed at resolving the etiological heterogeneities suspected for most of the common diseases. Complex phenotypes currently under study include prostate cancer, type 2 diabetes, schizophrenia, asthma and Parkinson's disease. In addition, I continue to study 11 closely related Midwest Amish communities. The members of this population are among the most inbred in North America and, as expected, are segregating a number of rare recessive diseases.
Goddard KAB, Witte JS, Suarez BK, Catalona WJ, Olson JM: Model-free linkage analysis with covariates confirms linkage of prostate cancer to chromosomes 1 and 4. Am J Hum Genet 2001; 68:1197-1206.
Suarez BK, Gerhard DS, Lin J, Haberer B, Nguyen L, Kesterson NK, Catalona WJ: Polymorphisms in the prostate cancer susceptibility gene HPC2/ELAC2 in multiplex families and healthy controls. Cancer Res 2001; 61:4982-4984.
Todorov A, Suarez BK: Liability model. In Biostatistical Genetics and Genetic Epidemiology [Elston RC, Olson J, Palmer L. eds.], Wiley, New York, 2002, pp 430-435.
Racette BA, Rundle M, Wang JC, Goate A, Saccone NL, Farrer M, Lin J, Suarez BK, Parsian A, Perlmutter JS: A multiincident, Old-Order Amish family with parkinson disease. Neurology 2002; 58:568-574.
Culverhouse R, Suarez BK, Lin J, Reich T: A perspective on epistasis: Limits of models displaying no main effect. Am J Hum Genet 2002; 70:461-471.
Funded Research Projects
Urological Research Foundation(PI):Studies on the Genetics of Prostate Cancer and Follow-up of Men Diagnosed with Prostate Cancer in the PSA Study