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Yvette I. Sheline, MD

Current Position
Professor of Psychiatry

University Roles
Director, Center for Depression Stress & Neuroimaging
Director, Faculty Development

Education and Training
B.A.: Biology, Harvard College, Cambridge, Massachusetts, 1974
M.S.: Neurophysiology, Yale University, New Haven, Connecticut, 1975
Medical Degree: Boston University, Boston, Massachusetts, 1979
Residency: Psychiatry, Harvard University at Beth Israel Hospital, Boston, Massachusetts, 1983

Major Awards
NIH Mid-Career Investigator Award,2002-2007
NIH-Mid-Career Investigator Award, 2007-2012
NARSAD Klerman Award Award Honorable Mention, 2005
NARSAD Klerman Award Honorable Mention, 2002
NARSAD Independent Investigator Award, 2002
NARSAD Young Investigator Award, 1998
NIMH Academic Career Development Award (K07), 1996



Areas of Clinical Interest
Depression & stress disorders


Areas of Research Interests
Dr. Sheline is currently conducting studies on treatment outcome in late-life depression, fMRI studies of emotional dysregulation in depression and PTSD, and studies investigating abnormal amyloid binding in late life depression, among others.


More articles and abstracts at the National Library of Medicine

Key Publications
Cirrito JR, Disabato BM, Restivo JL, Verges DK, Goebel WD, Sathyan A, Hayreh D, D’Angelo G, Benzinger T, Yoon H, Kim J, Morris JC, Mintun MA, Sheline YI. Serotonin signaling is associated with lower amyloid –{beta} levels and plaques in transgenic mice and humans. Proc Natl Acad Sci USA 108: 14968-73 (2011). PMCID: PMC3169155.

Sheline YI, Pieper CF, Barch DM, Welsh-Bohmer K, McKinstry RC, MacFall JR, D'Angelo G, Garcia KS, Gersing K, Wilkins C, Taylor W, Steffens DC, Krishnan RR, Doraiswamy PM (2010 Mar). Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial. Arch Gen Psychiatry. 67(3): 277-85.  Full Article ->

Sheline YI, Price JL, Yan Z, Mintun MA (2010 Jun 15). Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus. Proc Natl Acad Sci U S A. 107(24): 11020-5.  Full Article ->

Sheline YI, Morris JC, Snyder AZ, Price JL, Yan Z, D’Angelo G, Liu C, Dixit S, Benzinger T, Fagan A, Goate A, Mintun MA. APOE4 Allele Disrupts Resting State fMRI Connectivity in the Absence of Amyloid Plaques or Decreased CSF Aß42. J Neurosc. 30:17035-40 (2010). PMCID: PMC3023180.

Fales CL, Barch DM, Rundle MM, Mintun MA, Mathews J, Snyder AZ, Sheline YI (2009 Jan). Antidepressant treatment normalizes hypoactivity in dorsolateral prefrontal cortex during emotional interference processing in major depression. J Affect Disord. 112(1-3): 206-11.  Full Article ->

Sheline YI, Gado MH, Kraemer HC (2003 Aug). Untreated depression and hippocampal volume loss. Am J Psychiatry. 160(8): 1516-8.  Full Article ->


Funded Research Projects
NIMH(PI):Vascular Depression: Longitudinal Followup
NIMH(PI):fMRI Studies of Emotional Circuitry in Depression
NIMH(PI):Neuroimaging in Depression Treatment Studies
NIA(PI):Citalopram Decreases Amyloid-B Synthesis in Human CSF
NIA(Key Personnel):Antecedent Biomarkers for the AD: The Adult Children Study