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Yukitoshi Izumi, MD, PhD

Current Position
Professor of Psychiatry


Areas of Research Interests
I have over 30 years of experience in investigating synaptic plasticity including long-term potentiation (LTP), long-term depression (LTD) and modulation of hippocampal function by various drugs. We have had long-standing interests in understanding how synaptic function can be modulated under physiological and pathological conditions. Over 25 years I have been collaborating with Dr. Charles F. Zorumski. We have had long-standing interests in understanding how synaptic function can be modulated under physiological and pathological conditions.


Key Publications
Izumi Y, Clifford DB, Zorumski CF: Inhibition of long-term potentiation by NMDA-mediated nitric oxide release. Science 1992; 257:1273-1276.  Full Article ->

Izumi Y, Benz AM, Zorumski CF, Olney J: Effects of lactate and pyruvate on glucose deprivation in rat hippocampal slices. NeuroReport 1994; 5:617-620.  Full Article ->

Izumi Y, Benz AM, Katsuki H, Zorumski CF. Endogenous monocarboxylates sustain hippocampal synaptic function and morphological integrity during energy deprivation. J Neurosci. 1997 Dec 15;17(24):9448-57.   Full Article ->

Izumi Y, Ishii K, Katsuki H, Benz AM, Zorumski CF. beta-Hydroxybutyrate fuels synaptic function during development. Histological and physiological evidence in rat hippocampal slices. J Clin Invest. 1998 Mar 1;101(5):1121-32.   Full Article ->

Izumi Y, Benz AM, Kirby CO, Labruyere J, Zorumski CF, Price MT, Olney JW: An ex vivo rat retinal preparation for excitotoxicity studies. Journal of Neuroscience Methods 1995; 60:219-225.  Full Article ->

Izumi Y, Zorumski CF. NMDA receptors, mGluR5, and endocannabinoids are involved in a cascade leading to hippocampal long-term depression. Neuropsychopharmacology. 2012 Feb;37(3):609-617.   Full Article ->


Funded Research Projects
Juvenile Diabetes Research Foundation(Key Personnel):Hypoglycemia-Induced Synaptic Dysfunction in the Developing Brain
NIMH(Key Personnel):Modulation of Hippocampal Synaptic Plasticity