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Tamara Hershey, PhD

Current Position
Professor of Psychiatry, of Neurology and of Radiology

Education and Training
B.A., Psychology, Earlham College, IN
Ph.D., Clinical Psychology (Neuropsychology), Washington University in St. Louis


Areas of Research Interests
Neuropathophysiology underlying cognitive and mood aspects of Parkinson’s disease and other dopaminergic disorders.
Neuropathophysiological and behavioral effects of obesity and diabetes.
Using neuroimaging (MRI, fMRI and PET) and neuropsychological techniques, we study:
1) effects of severe hypoglycemia and hyperglycemia on the brain in children and adults with type 1 diabetes mellitus.
2) neurodevelopmental and neurodegenerative changes in Wolfram syndrome
3) relationship between obesity and dopamine receptors in the brain, their relationship to behavioral features and weight loss.
4) effects of Parkinson’s disease on cognitive and mood processes; how deep brain stimulation of the subthalamic nucleus affects brain function.

Key Publications
Lugar HM, Koller JM, Rutlin J, Marshall BA, Kanekura K, Urano F, Bischoff AN, Shimony JS, Hershey T, Washington University Wolfram Syndrome Research Study Group (2016). Neuroimaging evidence of deficient axon myelination in Wolfram syndrome. Sci Rep; 6: 21167. PMCID: PMC4758056  Full Article ->

Bischoff A, Reiersen A, Buttlaire A, Al-lozi A, Doty T, Marshall B, Hershey T (2015). Selective cognitive and psychiatric manifestations in Wolfram Syndrome. Orphanet J Rare Dis; 10(1): 66. PMCID: PMC4450481  Full Article ->

Eisenstein SA, Bischoff AN, Gredysa DM, Antenor-Dorsey JA, Koller JM, Al-Lozi A, Pepino de Gruev MY, Klein S, Perlmutter J, Moerlein SM, Black KJ, Hershey T (2015). Emotional eating phenotype is associated with central dopamine D2 receptor binding independent of body mass index. Sci Report; 5: 11283. PMCID: PMC4464302  Full Article ->

Eisenstein SA, Gredysa DM, Antenor-Dorsey J, Green L, Arbelaez AM, Koller JM, Black KJ, Perlmutter JS, Moerlein SM, Hershey T (2015). Insulin, central dopamine D2 receptors, and monetary reward discounting in obesity. PlosOne; 10(7): e0133621. PMCID: PMC4507849  Full Article ->

Eggebrecht AT, Ferradal SL, Robichaux-Viehoever A, Hassanpour MS, Dehghani H, Snyder AZ, Hershey T, Culver JP (2014). Mapping distributed brain function and networks with diffuse optical tomography. Nat Photonics; 8(6): 448-54. PMCID: PMC4114252  Full Article ->

Arbeláez AM, Semenkovich K, Hershey T (2013). Glycemic extremes in youth with T1DM: the structural and functional integrity of the developing brain. Pediatr Diabetes; 14(8): 541-53. PMCID: PMC3857606

Antenor-Dorsey JA, Meyer E, Rutlin J, Perantie D, White NH, Shimony J, Hershey T (2013). White matter microstructural integrity in youth with type 1 diabetes. Diabetes; 62(2): 581-9. PMCID: PMC3554385

Hershey T, Lugar H, Shimony J, Rutlin J, Koller JM, Perantie DC, Paciorkowski AR, Eisenstein SA, Permutt MA, the Washington University Wolfram Study Group (2012). Early brain vulnerability in Wolfram syndrome. PLoS One; 7(7): e40604. PMCID: PMC3394712

Funded Research Projects
NICHD (PI): Tracking Neurodegeneration in Early Wolfram Syndrome
NIDDK (PI): Early Predictors of Brain Health and Development in Youth with T1DM
NINDS (PI): Using Diffuse Optical Tomography to Understand Deep Brain Stimulations Impact on Cortical Networks
NIA (Key Personnel): Remediating Age Related Cognitive Decline: Mindfulness-Based Stress Reduction and Exercise
NINDS (Key Personnel): Glucose Metabolism and the Default Mode Network in Health and Disease
NIEHS (Key Personnel): Imaging Biomarkers of Neurotoxicity in Welders
NIEHS (Key Personnel): Motor and Cognitive Health Outcomes in a Mn-Exposed African Community
NICHD (Key Personnel): Type One Diabetes in the Brain in Children: Metabolic Interventions
NICHD (Key Personnel): Ischemic Conditioning as a Neurorecovery Agent for Stroke
Children's Discovery Institute (Key Personnel): Effects of Childhood Malnutrition on Brain Development
Barnes-Jewish Hospital Foundation (Key Personnel): Complex Effects of Dietary Manipulation on Metabolic Function, Inflammation and Health
NIDDK (Key Personnel): Clinical Trial of Dantrolene Sodium in Patients with Wolfram Syndrome