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Tamara Hershey, PhD

Current Position
Professor of Psychiatry

Education and Training
B.A., Earlham College, IN
Ph.D., Clinical Psychology (Neuropsychology), Washington University in St. Louis


Areas of Research Interests
Neuropathophysiology underlying cognitive and mood aspects of Parkinson’s disease and other dopaminergic disorders.
Neuropathophysiological and behavioral effects of obesity and diabetes.
Using neuroimaging (MRI, fMRI and PET) and neuropsychological techniques, we study:
1) effects of severe hypoglycemia and hyperglycemia on the brain in children and adults with type 1 diabetes mellitus.
2) neurodevelopmental and neurodegenerative changes in Wolfram syndrome
3) relationship between obesity and dopamine receptors in the brain, their relationship to behavioral features and weight loss.
4) effects of Parkinson’s disease on cognitive and mood processes; how deep brain stimulation of the subthalamic nucleus affects brain function.

Key Publications
Hershey T, Lugar HM, Shimony JS, Rutlin J, Koller JM, Perantie DC, Paciorkowski AR, Eisenstein SA, Permutt MA, the Washington University Wolfram Study Group (2012). Early Brain Vulnerability in Wolfram Syndrome. PLoS One. 7(7): e40604.  Full Article ->

Eisenstein SA, Koller JM, Piccirillo M, Kim A, Antenor-Dorsey JA, Videen TO, Snyder AZ, Karimi M, Moerlein SM, Black KJ, Perlmutter JS, Hershey T (2012 Sep). Characterization of extrastriatal D2 in vivo specific binding of [(18) F](N-methyl)benperidol using PET. Synapse. 66(9): 770-80.  Full Article ->

Perantie DC, Koller JM, Weaver PM, Lugar HM, Black KJ, White NH, Hershey T (2011 Nov). Prospectively determined impact of type 1 diabetes on brain volume during development. Diabetes. 60(11): 3006-14.  Full Article ->

Pickett KA, Duncan RP, Paciorkowski AR, Permutt MA, Marshall B, Hershey T, Earhart GM, the Washington University Wolfram Study Group (2012 Jul). Balance impairment in individuals with Wolfram syndrome. Gait Posture. 36(3): 619-624.  Full Article ->

Hershey T, Campbell MC, Videen TO, Lugar HM, Weaver PM, Hartlein J, Karimi M, Tabbal SD, Perlmutter JS (2010 Dec). Mapping Go-No-Go performance within the subthalamic nucleus region. Brain. 133(Pt 12): 3625-34.  Full Article ->

Arbelaez AM, Hershey T, Poweers WJ, Videen TO, Cryer PE. Selective thalamic activation and sympathoadrenal activation during hypoglycemia in humans. Diabetes, In press 2012

Funded Research Projects
NINDS(PI):Mapping Mood in the Subthalamic Nucleus in PD

NIDDK(PI):Glycemic Control, Brain Structure and Cognition in Youth with T1DM

NICHD(Key Personnel):DirecNet Study Group - Bedtime Beta2-adrenergic Agonist Therapy to Prevent Hypoglycemia in Children with Type 1 Diabetes

NIDDK(PI):Central Dopamine Receptors in Obesity

NINDS(Key Personnel):Mechanisms of Deep Brain Stimulation

ICTS(Key Personnel):Translating Mechanisms for a Genetic Neurodegenerative Disease into New Therapies

NCCAM(Key Personnel):Mindfulness-based Stress Reduction and Cognitive function in Stress and Aging

NIMH(Key Personnel):Testing the Phasic Dopamine Release Hypothesis in Tourette Syndrome