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Steven Mennerick, PhD

Current Position
Professor of Psychiatry

University Roles
Ph.D. teaching
T32 Training Directors group
Faculty Director of Ph.D. Admissions, DBBS
Member of Taylor Family Institute for Innovative Psychiatric Research

Education and Training
PhD, Neurosciences, Washington University
postdoctoral, SUNY Stony Brook

Major Awards
Klingenstein Award in the Neurosciences
NARSAD Young Investigator Award
Graduate Student Mentorship Award


  

Areas of Research Interests
The broad aim of my research is to understand control of neuronal excitation and inhibition by neurotransmitters in the central nervous system. This is an important goal because neurotransmitter actions can be double-edged, underlying normal neurotransmission on the one hand and underlying dysfunction and neurotoxicity on the other. In one project we are exploring the cellular and synaptic responses to powerful neuromodulators that affect inhibition and excitation. These molecules may modulate normal and abnormal brain function endogenously but also represent targets for novel therapeutic approaches. Another project investigates the effect that astrocytes, a class of glial cell, have on neuronal development and function. Finally, we have been engineering a biosensor for the neurotransmitter dopamine, allowing us a unique perspective on the control of dopamine release. For our studies we use electrophysiological, molecular, and imaging techniques applied to simple culture preparations, to heterologous expression systems, and to intact brain slices.


More articles and abstracts at the National Library of Medicine

Key Publications
Paul SM, Doherty JJ, Robichaud AJ, Belfort GM, Chow BY, Hammond RS, Crawford DC, Linsenbardt AJ, Shu HJ, Izumi Y, Mennerick SJ, Zorumski CF (2013 Oct 30). The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors. J Neurosci. 33(44): 17290-300.  Full Article ->

Emnett CM, Eisenman LN, Taylor AM, Izumi Y, Zorumski CF, Mennerick S (2013 Dec). Indistinguishable synaptic pharmacodynamics of the N-methyl-D-aspartate receptor channel blockers memantine and ketamine. Mol Pharmacol. 84(6): 935-47.  Full Article ->

Lyons-Warren AM, Kohashi T, Mennerick S, Carlson BA (2013 Nov). Detection of submillisecond spike timing differences based on delay-line anticoincidence detection. J Neurophysiol. 110(10): 2295-311.  Full Article ->

Zorumski CF, Mennerick S (2013 Jul). Neurosteroids as therapeutic leads in psychiatry. JAMA Psychiatry. 70(7): 659-60.  Full Article ->

Linsenbardt AJ, Chisari M, Yu A, Shu HJ, Zorumski CF, Mennerick S (2013 Feb). Noncompetitive, voltage-dependent NMDA receptor antagonism by hydrophobic anions. Mol Pharmacol. 83(2): 354-66.  Full Article ->

Crawford DC, Jiang X, Taylor A, Mennerick S (2012 Sep 19). Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro. J Neurosci. 32(38): 13100-10.  Full Article ->


Funded Research Projects
NIMH(PI):Control of Synaptic Glutamate Release
NIMH(Key Personnel):Modulation of Hippocampal Synaptic Plasticity
NIDA (PI): Nicotinic modulation of dopamine release studied with a channel-based biosensor
NIMH (PI): Receptor populations underlying tonic GABA currents in inhibition