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Michele Pergadia, PhD

Current Position
Associate Professor of Psychiatry

Education and Training
B.A. Psychology and Biology, Washington University
Ph.D. Clinical Psychology, FUHS/The Chicago Medical School
Health Psychology Internship, Rush Presbyterian St. Luke's
Postdoctoral Fellowship, Washington University School of Medicine

Areas of Clinical Interest
Smoking Cessation, Cognitive-Behavioral Therapy

Areas of Research Interests
My research centers on factors associated with use of tobacco products, particularly nicotine withdrawal and related conditions such as major depression. The perspective is translational and seeks to integrate various methods to improve our understanding of smoking behavior, including epidemiologic, genetic, human laboratory, and animal models. It also considers translation to practice, by examining dissemination of empirically supported treatment for smoking cessation.

Key Publications
Pergadia ML, Der-Avakian A, D'Souza MS, Madden PAF, Heath AC, Shiffman S, Markou A, Pizzagalli DA, (2014 Nov). Association between nicotine withdrawal and reward responsiveness in humans and rats. JAMA Psychiatry. 71(11): 1238-1245.  Full Article ->

Pergadia ML, Glowinski AL, Wray NR, Agrawal A, Saccone SF, Loukola A, Broms U, Korhonen T, Penninx BW, Grant JD, Nelson EC, Henders AK, Schrage AJ, Chou YL, Keskitalo-Vuokko K, Zhu Q, Gordon SD, Vink JM, de Geus EJ, Macgregor S, Liu JZ, Willemsen G, Medland SE, Boomsma DI, Montgomery GW, Rice JP, Goate AM, Heath AC, Kaprio J, Martin NG, Madden PA (2011 Aug). A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families. Am J Psychiatry. 168(8): 848-52.  Full Article ->

Breen G, Lewis CM, Vassos E, Pergadia ML, Blackwood DH, Boomsma DI, Penninx B, Sullivan PF, Pedroso I, Collier D, McGuffin P (2011 Jan). Replication of association of 3p21.1 with susceptibility to bipolar disorder but not major depression. Nat Genet. 43(1): 3-5; author reply 5.  Full Article ->

Pergadia ML, Heath AC, Martin NG, Madden PA (2006 Jul). Genetic analyses of DSM-IV nicotine withdrawal in adult twins. Psychol Med. 36(7): 963-72.  Full Article ->

Pergadia ML, Agrawal A, Loukola A, Montgomery GW, Broms U, Saccone SF, Wang JC, Todorov AA, Heikkila K, Statham DJ, Henders AK, Campbell MJ, Rice JP, Todd RD, Heath AC, Goate AM, Peltonen L, Kaprio J, Martin NG, Madden PA (2009 Oct 5). Genetic linkage findings for DSM-IV nicotine withdrawal in two populations. Am J Med Genet B Neuropsychiatr Genet. 150B(7): 950-9.  Full Article ->

Pergadia ML, Heath AC, Agrawal A, Bucholz KK, Martin NG, Madden PA (2006 Jul). The implications of simultaneous smoking initiation for inferences about the genetics of smoking behavior from twin data. Behav Genet. 36(4): 567-76.  Full Article ->

Funded Research Projects
NIDA (Co-I, site-PI): Predictors of Light Smoker Trajectories
NSF (Co-PI): CC*DNI Networking Infrastructure: Enabling Multi-Campus, Data-Driven Science and Engineering through a 10Gb FAU DMZ
Barnes-Jewish Hospital Foundation (PI): Smoking Cessation Services: An Integrated Care Model for the Primary Care Medicine Clinic
NIDA (PI):Refining Phenotypic Measures of Nicotine Withdrawal
NIAAA (Key Personnel):Alcoholism: Epidemiologic High Risk Family Study - MOFAM
NIAAA (Key Personnel):Molecular Epidemiology of Alcoholism 3 - EDAC Families
NIDA (Key Personnel): The Genetics of Vulnerability to Nicotine Addiction