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Celeste Karch, PhD

Current Position
Assistant Professor of Psychiatry

Education and Training
2005 BA, Kalamazoo College, Kalamazoo, MI
2009 PhD, University of Florida, Gainesville, FL


  

Areas of Research Interests
neurodegeneration, neurogenetics, Alzheimer's disease, frontotemporal dementia, tau, amyloid precursor protein, induced pluripotent stem cells (iPSC), cell and molecular biology, molecular mechanisms


Key Publications
Karch Celeste M.,Ezerskiy Lubov A.,Bertelsen Sarah,Goate Alison M.,Huang Qingyang,;Alzheimer’s Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci;;  Full Article ->

Karch Celeste M,Ezerskiy Lubov,Redaelli Veronica,Giovagnoli Annarita,Tiraboschi Pietro,Pelliccioni Giuseppe,Pelliccioni Paolo,Kapetis Dimos,Ilaria D'Amato,Piccoli Elena,Ferretti Maria Giulia,Fabrizio Tagliavini,Rossi Giacomina,;Missense mutations in progranulin gene associated with frontotemporal lobar degeneration: study of pathogenetic features;February 2016;;  Full Article ->

Cruchaga C, Karch CM, Jin SC, Benitez BA, Cai Y, Guerreiro R, Harari O, Norton J, Budde J, Bertelsen S, Jeng AT, Cooper B, Skorupa T, Carrell D, Levitch D, Hsu S, Choi J, Ryten M, UK Brain Expression Consortium, Hardy J, Ryten M, Trabzuni D, Weale ME, Ramasamy A, Smith C, Sassi C, Bras J, Gibbs JR, Hernandez DG, Lupton MK, Powell J, Forabosco P, Ridge PG, Corcoran CD, Tschanz JT, Norton MC, Munger RG, Schmutz C, Leary M, Demirci FY, Bamne MN, Wang X, Lopez OL, Ganguli M, Medway C, Turton J, Lord J, Braae A, Barber I, Brown K, Alzheimer’s Research UK Consortium, Passmore P, Craig D, Johnston J, McGuinness B, Todd S, Heun R, Kölsch H, Kehoe PG, Hooper NM, Vardy ER, Mann DM, Pickering-Brown S, Brown K, Kalsheker N, Lowe J, Morgan K, David Smith A, Wilcock G, Warden D, Holmes C, Pastor P, Lorenzo-Betancor O, Brkanac Z, Scott E, Topol E, Morgan K, Rogaeva E, Singleton AB, Hardy J, Kamboh MI, St George-Hyslop P, Cairns N, Morris JC, Kauwe JS, Goate AM (2014 Jan 23). Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. Nature. 505(7484): 550-4.  Full Article ->

Cruchaga C, Kauwe JS, Harari O, Jin SC, Cai Y, Karch CM, Benitez BA, Jeng AT, Skorupa T, Carrell D, Bertelsen S, Bailey M, McKean D, Shulman JM, De Jager PL, Chibnik L, Bennett DA, Arnold SE, Harold D, Sims R, Gerrish A, Williams J, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Peskind ER, Galasko D, Fagan AM, Holtzman DM, Morris JC, GERAD Consortium, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer Disease Genetic Consortium (ADGC), Goate AM (2013 Apr 24). GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron. 78(2): 256-68.  Full Article ->

Karch CM, Jeng AT, Nowotny P, Cady J, Cruchaga C, Goate AM (2012). Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains. PLoS One. 7(11): e50976.  Full Article ->

Karch CM, Jeng AT, Goate AM (2012 Dec 14). Extracellular Tau levels are influenced by variability in Tau that is associated with tauopathies. J Biol Chem. 287(51): 42751-62.  Full Article ->


Funded Research Projects
NIA:Genetic Disruption of Tau Metabolism in Tauopathies

BrightFocus Foundation:Defining the Role of Phospholipase D3 in Alzheimer's Disease Pathogenesis

McDonnell Center for Cellular and Molecular Neurobiology:The role of MAPT mutations on tau kinetics in a human neuronal model of frontotemporal dementia

Hope Center Pilot: Neuronal subtype-specific vulnerability in tauopathies using reprogramming methods in human somatic and stem cells

Rainwater Charitable Foundation:Observational Study of Familial Frontotemporal Dementia Caused by MAPT Mutations

Rainwater Charitable Foundation(Key Personnel):MAPT A152T/Tauopathy Systems Neuropathology Project