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Li-Shiun Chen, MD

Current Position
Assistant Professor of Psychiatry

Education and Training
M.D., National Taiwan University, Taiwan, 1993
M.P.H., Johns Hopkins University, Maryland,1995
Sc.D., Johns Hopkins University, Maryland, 1998
Psychiatry Residency, Washington University/Barnes-Jewish Hospital, St. Louis, 2004

Major Awards
Eli Robins Award, Washington University Department of Psychiatry, 2004
APA Resident Research Award, 2004
World Congress of Psychiatric Genetics Travel Award, 2009

Areas of Clinical Interest
Schizophrenia, Mood Disorder, Addiction, Personality Disorder, Community Psychiatry, Telepsychiatry, Cancer Psychiatry


Areas of Research Interests
1. Precision medicine
2. Clinical trials
3. Genetics of smoking cessation and treatment
4. Implementating smoking cessation treatment in patients with mental illness
5. Cross-population and longitudinal studies
6. Public health genomics

More articles and abstracts at the National Library of Medicine

Key Publications
Chen LS, Hung RJ., Baker TB, Horton A, Culverhouse R, Saccone NL, Cheng I, Deng B, et al, Spitz, MR, Kraft P, Amos CI, Bierut LJ, 2015. CHRNA5 Risk Variant Predicts Delayed Smoking Cessation and Earlier Lung Cancer Diagnosis-A Meta-Analysis. J Natl Cancer Inst. 2015 Apr 14;107(5)  Full Article ->

33. Chen LS, Baker TB, Jorenby D, Piper M, Saccone N, Johnson E, Breslau N, Hatsukami D, Carney RM, Bierut LJ. Genetic variation (CHRNA5), medication (combination nicotine replacement therapy vs. varenicline), and smoking cessation. Drug Alcohol Depend. 2015;154:278-282  Full Article ->

Chen LS, Bloom AJ, Baker TB, Smith SS, Piper ME, Martinez M, Saccone N, Hatsukami D, Goate A, Bierut L (2014 Jan). Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene (CYP2A6). Addiction. 109(1): 128-37.  Full Article ->

Chen LS, Baker TB, Piper ME, Breslau N, Cannon DS, Doheny KF, Gogarten SM, Johnson EO, Saccone NL, Wang JC, Weiss RB, Goate AM, Bierut LJ (2012 Jul 1). Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation success. Am J Psychiatry. 169(7): 735-42.  Full Article ->

Chen LS, Bach RG, Lenzini PA, Spertus JA, Bierut LJ, Cresci S (2014 Sep). CHRNA5 variant predicts smoking cessation in patients with acute myocardial infarction. Nicotine Tob Res. 16(9): 1224-31.  Full Article ->

Chen LS, Saccone NL, Culverhouse RC, Bracci PM, Chen CH, Dueker N, Han Y, Huang H, Jin G, Kohno T, Ma JZ, Przybeck TR, Sanders AR, Smith JA, Sung YJ, Wenzlaff AS, Wu C, Yoon D, Chen YT, Cheng YC, Cho YS, David SP, Duan J, Eaton CB, Furberg H, Goate AM, Gu D, Hansen HM, Hartz S, Hu Z, Kim YJ, Kittner SJ, Levinson DF, Mosley TH, Payne TJ, Rao DC, Rice JP, Rice TK, Schwantes-An TH, Shete SS, Shi J, Spitz MR, Sun YV, Tsai FJ, Wang JC, Wrensch MR, Xian H, Gejman PV, He J, Hunt SC, Kardia SL, Li MD, Lin D, Mitchell BD, Park T, Schwartz AG, Shen H, Wiencke JK, Wu JY, Yokota J, Amos CI, Bierut LJ (2012 May). Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25. Genet Epidemiol. 36(4): 340-51.  Full Article ->

Funded Research Projects
NIDA (PI): Genetic and Environmental Risks for Smoking Characteristics and Cessation
NIDA (PI): Genetically Informed Smoking Cessation Trial