Return to the Faculty List

Li-Shiun Chen, MD

Current Position
Associate Professor of Psychiatry

Education and Training
M.D., National Taiwan University, Taiwan, 1993
M.P.H., Johns Hopkins University, Maryland,1995
Sc.D., Johns Hopkins University, Maryland, 1998
Psychiatry Residency, Washington University/Barnes-Jewish Hospital, St. Louis, 2004

Major Awards
Eli Robins Award, Washington University Department of Psychiatry, 2004
APA Resident Research Award, 2004
World Congress of Psychiatric Genetics Travel Award, 2009

Areas of Clinical Interest
Schizophrenia, Mood Disorder, Addiction, Personality Disorder, Community Psychiatry, Telepsychiatry, Cancer Psychiatry


Areas of Research Interests
1. Precision medicine
2. Clinical trials
3. Genetics of smoking cessation and treatment
4. Implementation of smoking cessation treatment
5. Cross-population and longitudinal studies
6. Public health genomics

More articles and abstracts at the National Library of Medicine

Key Publications
Chen LS, Baker T, Brownson RC, Carney RM, Jorenby D, Hartz S, Smock N, Johnson M, Ziedonis D, Bierut LJ, (2016 Nov). Smoking Cessation and Electronic Cigarettes in Community Mental Health Centers: Patient and Provider Perspectives. Community Ment Health J. .  Full Article ->

Chen LS, Baker T, Hung RJ, Horton A, Culverhouse R, Hartz S, Saccone N, Cheng I, Deng B, Han Y, Hansen HM, Horsman J, Kim C, Rosenberger A, Aben KK, Andrew AS, Chang SC, Saum KU, Dienemann H, Hatsukami DK, Johnson EO, Pande M, Wrensch MR, McLaughlin J, Skaug V, van der Heijden EH, Wampfler J, Wenzlaff A, Woll P, Zienolddiny S, Bickeböller H, Brenner H, Duell EJ, Haugen A, Brüske I, Kiemeney LA, Lazarus P, Le Marchand L, Liu G, Mayordomo J, Risch A, Schwartz AG, Teare MD, Wu X, Wiencke JK, Yang P, Zhang ZF, Spitz MR, Amos CI, Bierut LJ, (2016 Sep). Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes - A Meta-Analysis. EBioMedicine. 11: 219-226.  Full Article ->

Chen LS, Hung RJ., Baker TB, Horton A, Culverhouse R, Saccone NL, Cheng I, Deng B, et al, Spitz, MR, Kraft P, Amos CI, Bierut LJ, 2015. CHRNA5 Risk Variant Predicts Delayed Smoking Cessation and Earlier Lung Cancer Diagnosis-A Meta-Analysis. J Natl Cancer Inst. 2015 Apr 14;107(5)  Full Article ->

Chen LS, Bloom AJ, Baker TB, Smith SS, Piper ME, Martinez M, Saccone N, Hatsukami D, Goate A, Bierut L (2014 Jan). Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene (CYP2A6). Addiction. 109(1): 128-37.  Full Article ->

Chen LS, Baker TB, Piper ME, Breslau N, Cannon DS, Doheny KF, Gogarten SM, Johnson EO, Saccone NL, Wang JC, Weiss RB, Goate AM, Bierut LJ (2012 Jul 1). Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation success. Am J Psychiatry. 169(7): 735-42.  Full Article ->

Chen LS, Baker, TB, Korpecki, JM, Johnson KE, Hook JP, Brownson RC, Bierut LJ. Low-burden strategies to promote smoking cessation treatment in patients with serious mental illness. Psychiatric Services. 2018 in press.  Full Article ->

Funded Research Projects
NIDA (PI): Genetically Informed Smoking Cessation Trial
NCI (Supplement PI): Cancer Center Tobacco Cessation
NIDA (Co-I): Nicotine Dependence to Smoking Cessation: Sequencing Common and Rare Variants
NCI (Co-I): Integrative Analysis of Lung Cancer Etiology and Risk
Taiwan NHRI (Co-I): Genetic Study of Addiction and Smoking Cessation