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Charles Conway, MD

Current Position
Professor of Psychiatry

University Roles
Director, Treatment Resistant Depression and Neurostimulation Clinic
Director, Washington University Center for the Advancement of Research in Resistant Mood and Affective Disorders (CARRMA)
Interventional Psychiatry Rotation Director

Education and Training
B.A., Biology; B.A., Psychology
St. Louis University, 1987

Medical Degree: University of Missouri, Columbia, 1995

Residency: General Psychiatry, Duke University Medical Center, 1999

Major Awards
-Ziskind-Somerfeld Research Award, Society of Biological Psychiatry 2016 (selected for Nagele 2015 publication for highest priority score during peer review)
-Best Doctors in America, (Best Doctors, Inc.) 2006-present
-Resident Faculty Teaching Award 2014 (chosen by residents), Washington University Department of Psychiatry
-Resident Mentor Award 2011 (chosen by residents), Washington University Department of Psychiatry
-NARSAD Sidney Baer Award 2007
-St. Louis University Psych Dept. Resident Faculty Teaching Award (selected by residents) 2004,2007
-Exemplary Psychiatrist Award, National Alliance for the Mentally Ill (NAMI) 2004
-St. Luke Award, Saint Louis University Hospital; (selected as a physician who 'Best lived out the Christian mission of St. Louis University Hospital') 2001
-Chief Resident, John Umstead Hospital, Duke University Psychiatry Residency 1998-1999
-Phi Beta Kappa 1986

Areas of Clinical Interest
mood disorders, treatment-resistant mood disorders, bipolar disorders


Areas of Research Interests
treatment-resistant depression (TRD) phenomenology, novel treatments for TRD, neuroimaging of mood disorders, bipolar disorders


Key Publications
Aaronson ST, Sears P, Ruvuna F, Bunker M, Conway CR, Dougherty DD, Reimherr FW, Schwartz TL, Zajecka JM. A 5-Year Observational Study of Patients With Treatment-Resistant Depression Treated With Vagus Nerve Stimulation or Treatment as Usual: Comparison of Response, Remission, and Suicidality. Am J Psychiatry, 2017 Mar. PMID: 28359201.  Full Article ->

Conway CR, George MS, Sackeim HA. Toward an Evidence-Based, Operational Definition of Treatment-Resistant Depression: When Enough Is Enough. JAMA Psychiatry, 2017. 74(1): 9-10. PMID: 27784055.  Full Article ->

Conway CR, Gebara MA, Walker MC, Lessov-Schlaggar CN, Janski AM, Chibnall JT, Cristancho P, Sheline YS, Gott BM, Svrakic DM. Clinical Characteristics and Management of Treatment-Resistant Depression. J Clin Psych, 2015; Nov; 76(11): 1569-70. PMID: 26646033.

Nagele P, Duma A, Kopec M, Gebara MA, Parsoei A, Walker M, Janski A, Panagopoulos VN, Cristancho P, Miller JP, Zorumski CF, Conway CR. Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial. Biological Psychiatry. 2015; Jul 1; 78(1). PMID: 25577164.

Conway CR, Chibnall JT, Gebara MA, Price JL, Snyder AZ, Mintun MA, Craig AD, Cornell ME, Perantie DC, Giuffra LA, Bucholz RD, Sheline YI. Association of cerebral metabolic activity changes with vagus nerve stimulation antidepressant response in treatment-resistant depression. Brain Stimulation, 2013; 6(5): 788-97. PMCID: PMC3954813.

Conway CR, Sheline YI, Chibnall JT, George MS, Fletcher JW, Mintun MA.
Cerebral Blood Flow Changes during Acute Vagus Nerve Stimulation for Depression.
Psychiatry Res: Neuroimaging, 2006; 146(2):179-184. PMID: 16510266.


Funded Research Projects
American Foundation of Suicide Prevention (Co-PI). Adjunctive Nitrous Oxide for Acute Suicidal Ideation in Unipolar Depressed Hospitalized Patients.

Assurex Health (PI). Combinatorial Pharmacogenomics Testing in Treatment-Naïve Major Depressive Disorder (MDD).

Brain and Behavior Research Foundation (Co-I). Inhaled Nitrous Oxide for Treatment-Resistant Depression: Optimizing Dosing Strategies.

Stanley Medical Research Institute (Co-PI). Nitrous Oxide for Bipolar Depression.

NIMH R21 (Co-PI). Targeting Affective Circuits Using the N-methyl-D-Aspartate (NMDA) Antagonist Nitrous Oxide.

McDonnell Center for Systems Neuroscience (Co-PI): Assessing Effects of Nitrous Oxide Inhalation on Functional Connectivity.

Taylor Family Institute for Innovative Psychiatric Research (PI): Biological and Psychological Phenomenology Studies of Treatment-Resistant Depressive Disorder.