Return to the Faculty List

Eric Lenze, MD

Current Position
Professor of Psychiatry

University Roles
Geriatric Psychiatry Rotation Director

Education and Training
M.D.: Washington University School of Medicine, 1994
Psychiatry Residency: Washington University School of Medicine, 1998
Geriatric Psychiatry Fellowship: University of Pittsburgh School of Medicine, 1999

Major Awards
Best Doctors in America (2005-present)

Areas of Clinical Interest
Treatment of anxiety disorders and depression in older adults.
Forensic Psychiatry (expert witness in older adult cases).


Areas of Research Interests
I am the Director of the Healthy Mind Lab. My main research focus is developing and testing treatments for depression and anxiety in older and younger adults.

My expertise is in clinical trials and clinical observational research; my work includes novel treatments (including Ketamine & Kappa opioid antagonists), predictors of response, neuroendocrinology, neuropsychology, pharmacotherapy, mindfulness, exercise, mobile technology, and medical rehabilitation.

More articles and abstracts at the National Library of Medicine

Key Publications
Lenze Eric J., Rollman Bruce L., Shear M. Katherine, Dew Mary Amanda, Pollock Bruce G., Ciliberti Caroline, Constantino Michelle, Snyder Sara, Shi Peichang, Spitznagel Edward, Andreescu Carmen, Butters Meryl A., Reynolds Charles F. Escitalopram for Older Adults With Generalized Anxiety Disorder;  Full Article ->

Lenze Eric J., Hickman Steven, Hershey Tamara, Wendleton Leah, Ly Khanh, Dixon David, DorĂ© Peter, Wetherell Julie Loebach. Mindfulness-Based Stress Reduction for older adults with worry symptoms and co-occurring cognitive dysfunction; October 2014.  Full Article ->

Lenze Eric J, Dew Mary Amanda, Mazumdar Sati, Begley Amy E, Cornes Cleon, Miller Mark D, Imber Stanley D, Frank Ellen, Kupfer David J, Reynolds Charles F. Combined pharmacotherapy and psychotherapy as maintenance treatment for late-life depression: effects on social adjustment.159:466-8;  Full Article ->

Reynolds Charles F, Dew Mary Amanda, Pollock Bruce G, Mulsant Benoit H, Frank Ellen, Miller Mark D, Houck Patricia R, Mazumdar Sati, Butters Meryl A, Stack Jacqueline A, Schlernitzauer Mary Ann, Whyte Ellen M, Gildengers Ariel, Karp Jordan, Lenze Eric, Szanto Katalin, Bensasi Salem, Kupfer David J. Maintenance treatment of major depression in old age. 354:1130-8;  Full Article ->

Lenze Eric J., Hershey Tamara, Newcomer John W., Karp Jordan F., Blumberger Daniel, Anger Jennifer, DorĂ© Peter, Dixon David. Antiglucocorticoid therapy for older adults with anxiety and co-occurring cognitive dysfunction: results from a pilot study with mifepristone;September 2014;;  Full Article ->

Lenze EJ, Mulsant BH, Blumberger DM, Karp JF, Newcomer JW, Anderson SJ, Dew MA, Butters MA, Stack JA, Begley AE, Reynolds CF: Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomized placebo-controlled trial. The Lancet. [in press]

Funded Research Projects
NCATS(Significant Contributor):Maximizing the Impact of the Multicenter Clinical Trial Enterprise
NIMH(PI):2/3 Buprenorphine for Treatment-resistant Late-life Depression
NIMH(PI):Enhanced Medical Rehabilitation for Older Adults
NIMH(Significant Contributor):2/3 Buprenorphine for Treatment-resistant Late-life Depression
James S. McDonnell Foundation(Significant Contributor):Reconstructing Consciousness and Cognition, Phase 2
NIMH(PI):Mechanisms of Cognitive Decline in Late-Life Anxiety Disorders
Patient-Centered Outcomes Research Institute(PI):Re-engineering Geriatric Post-acute Rehabilitation for Higher Engagement and Higher Intensity
NIMH(Key Personnel):An Efficient Method of Testing Pharmacological Enhancement for Treating Anxiety
NIMH(PI):2/3 Antiglucocorticoid Therapy for Cognitive Dysfunction in Late-life Anxiety
NIH(Significant Contributor):Novel Therapeutics Research Training Program
Food and Drug Administration(Key Personnel):Bioequivalence and Clinical Implications of Generic Bupropion
Barnes-Jewish Hospital Foundation(PI):Fall-related Injury Prevention: Pharmacogenomics to Improve Antidepressant Safety
NIA(Significant Contributor):Self-management to Prevent Falls in Older Adults with Cancer
NIA(Significant Contributor):Electroencephalograph Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES)
NIA(Significant Contributor):Implementation of Home Modifications to Prevent Falls for Older Adults at High Risk
NIA(PI):Remediating Age Related Cognitive Decline: Mindfulness-Based Stress Reduction and Exercise
McDonnell Center for Systems Neuroscience(PI):Functional Connectivity Mechanismsof NMDA Antagonist Treatment for Major Depressive Disorder
NCCIH(PI):Optimizing Interventions to Reverse Stress Effects on the Aging Brain
Patient-Centered Outcomes Research Institute(PI):Optimizing Outcomes in Treatment-Resistant Depression in Older Adults
NCATS(Significant Contributor):The NCATS Clinical Trial Mobile Suite
NIAMSD(Significant Contributor):Molecular Transducers of Physical Activity Adult Clinical Center
NIH(Key Personnel):Mindfulness-Based Stress Reduction on Insomnia for Adults with Chronic Pain due to Rheumatoid Arthritis