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Eric Lenze, MD

Current Position
Professor of Psychiatry

University Roles
Geriatric Psychiatry Rotation Director

Education and Training
M.D.: Washington University School of Medicine, 1994
Psychiatry Residency: Washington University School of Medicine, 1998
Geriatric Psychiatry Fellowship: University of Pittsburgh School of Medicine, 1999

Major Awards
Best Doctors in America (2005-present)

Areas of Clinical Interest
Treatment of anxiety disorders and depression in older adults.
Forensic Psychiatry (expert witness in older adult cases).


Areas of Research Interests
I am the Director of the Healthy Mind Lab. My main research focus is developing and testing treatments for depression and anxiety in older and younger adults.

My expertise is in clinical trials and clinical observational research; my work includes novel treatments (including Ketamine & Kappa opioid antagonists), predictors of response, neuroendocrinology, neuropsychology, pharmacotherapy, mindfulness, exercise, mobile technology, and medical rehabilitation.

More articles and abstracts at the National Library of Medicine

Key Publications
Lenze Eric J., Rollman Bruce L., Shear M. Katherine, Dew Mary Amanda, Pollock Bruce G., Ciliberti Caroline, Constantino Michelle, Snyder Sara, Shi Peichang, Spitznagel Edward, Andreescu Carmen, Butters Meryl A., Reynolds Charles F. Escitalopram for Older Adults With Generalized Anxiety Disorder;  Full Article ->

Lenze Eric J., Hickman Steven, Hershey Tamara, Wendleton Leah, Ly Khanh, Dixon David, DorĂ© Peter, Wetherell Julie Loebach. Mindfulness-Based Stress Reduction for older adults with worry symptoms and co-occurring cognitive dysfunction; October 2014.  Full Article ->

Lenze Eric J, Dew Mary Amanda, Mazumdar Sati, Begley Amy E, Cornes Cleon, Miller Mark D, Imber Stanley D, Frank Ellen, Kupfer David J, Reynolds Charles F. Combined pharmacotherapy and psychotherapy as maintenance treatment for late-life depression: effects on social adjustment.159:466-8;  Full Article ->

Reynolds Charles F, Dew Mary Amanda, Pollock Bruce G, Mulsant Benoit H, Frank Ellen, Miller Mark D, Houck Patricia R, Mazumdar Sati, Butters Meryl A, Stack Jacqueline A, Schlernitzauer Mary Ann, Whyte Ellen M, Gildengers Ariel, Karp Jordan, Lenze Eric, Szanto Katalin, Bensasi Salem, Kupfer David J. Maintenance treatment of major depression in old age. 354:1130-8;  Full Article ->

Lenze Eric J., Hershey Tamara, Newcomer John W., Karp Jordan F., Blumberger Daniel, Anger Jennifer, DorĂ© Peter, Dixon David. Antiglucocorticoid therapy for older adults with anxiety and co-occurring cognitive dysfunction: results from a pilot study with mifepristone;September 2014;;  Full Article ->

Lenze EJ, Mulsant BH, Blumberger DM, Karp JF, Newcomer JW, Anderson SJ, Dew MA, Butters MA, Stack JA, Begley AE, Reynolds CF: Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomized placebo-controlled trial. The Lancet. [in press]

Funded Research Projects
NIA (PI): Remediating Age Related Cognitive Decline: Mindfulness-Based Stress Reduction and Exercise

NIMH (PI): Enhanced Medical Rehabilitation for Older Adults

NIMH (PI): 2/3 Buprenorphine for Treatment-resistant Late-life Depression

McDonnell Center for Systems Neuroscience (PI): Functional Connectivity Mechanisms of NMDA Antagonist Treatment for Major Depressive Disorder

Barnes-Jewish Hospital Foundation (PI): Fall-related Injury Prevention: Pharmacogenomics to Improve Antidepressant Safety

Food and Drug Administration (Key Personnel): Bioequivalence and Clinical Implications of Generic Bupropion