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Eric Lenze, MD

Current Position
Professor of Psychiatry

University Roles
Geriatric Psychiatry Rotation Director

Education and Training
M.D.: Washington University School of Medicine, 1994
Psychiatry Residency: Washington University School of Medicine, 1998
Geriatric Psychiatry Fellowship: University of Pittsburgh School of Medicine, 1999

Major Awards
Best Doctors in America (2005-present)
Resident Mentoring award from Washington University Department of Psychiatry (2012)

Areas of Clinical Interest
Treatment of anxiety disorders and depression in older adults.


  

Areas of Research Interests
I am the Director of the Healthy Mind Lab. My main research focus is developing and testing treatments for depression and anxiety in older and younger adults.

My expertise is in clinical trials and clinical observational research; my work includes novel treatments (including Ketamine & Kappa opioid antagonists), predictors of response, neuroendocrinology, neuropsychology, pharmacotherapy, mindfulness, exercise, mobile technology, and medical rehabilitation.


More articles and abstracts at the National Library of Medicine

Key Publications
Lenze EJ, Rollman BL, Shear MK, Dew MA, Pollock BG, Ciliberti C, Costantino M, Snyder S, Shi P, Spitznagel E, Andreescu C, Butters MA, Reynolds CF, (2009 Jan). Escitalopram for older adults with generalized anxiety disorder: a randomized controlled trial. JAMA. 301(3): 295-303.  Full Article ->

Lenze EJ, Hickman S, Hershey T, Wendleton L, Ly K, Dixon D, Doré P, Wetherell JL, (2014 Oct). Mindfulness-based stress reduction for older adults with worry symptoms and co-occurring cognitive dysfunction. Int J Geriatr Psychiatry. 29(10): 991-1000.  Full Article ->

Lenze EJ, Mulsant BH, Blumberger DM, Karp JF, Newcomer JW, Anderson SJ, Dew MA, Butters MA, Stack JA, Begley AE, Reynolds CF, (2015 Dec). Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebo-controlled trial. Lancet. 386(10011): 2404-12.  Full Article ->

Lenze EJ, Mulsant BH, Blumberger DM, Karp JF, Newcomer JW, Anderson SJ, Dew MA, Butters MA, Stack JA, Begley AE, Reynolds CF, (2015 Dec). Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebo-controlled trial. Lancet. 386(10011): 2404-12.  Full Article ->

Wetherell JL, Hershey T, Hickman S, Tate SR, Dixon D, Bower ES, Lenze EJ, (2017 Jul). Mindfulness-Based Stress Reduction for Older Adults With Stress Disorders and Neurocognitive Difficulties: A Randomized Controlled Trial. J Clin Psychiatry. 78(7): e734-e743.  Full Article ->


Funded Research Projects
NCATS(Significant Contributor):Maximizing the Impact of the Multicenter Clinical Trial Enterprise
NIMH(PI):2/3 Buprenorphine for Treatment-resistant Late-life Depression
NIMH(PI):Enhanced Medical Rehabilitation for Older Adults
James S. McDonnell Foundation(Significant Contributor):Reconstructing Consciousness and Cognition, Phase 2
NIMH(PI):Mechanisms of Cognitive Decline in Late-Life Anxiety Disorders
Patient-Centered Outcomes Research Institute(PI):Re-engineering Geriatric Post-acute Rehabilitation for Higher Engagement and Higher Intensity
NIMH(Key Personnel):An Efficient Method of Testing Pharmacological Enhancement for Treating Anxiety
NIMH(PI):2/3 Antiglucocorticoid Therapy for Cognitive Dysfunction in Late-life Anxiety
NIH(Significant Contributor):Novel Therapeutics Research Training Program
Barnes-Jewish Hospital Foundation(PI):Fall-related Injury Prevention: Pharmacogenomics to Improve Antidepressant Safety
NIA(Significant Contributor):Self-management to Prevent Falls in Older Adults with Cancer
NIA(Significant Contributor):Electroencephalograph Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES)
NIA(Significant Contributor):Implementation of Home Modifications to Prevent Falls for Older Adults at High Risk
NIA(PI):Remediating Age Related Cognitive Decline: Mindfulness-Based Stress Reduction and Exercise
McDonnell Center for Systems Neuroscience(PI):Functional Connectivity Mechanismsof NMDA Antagonist Treatment for Major Depressive Disorder
NIH(Significant Contributor):Loving-Kindness Meditation and Yoga in the Return to Normal Psychological Functioning in Chronic Traumatic Brain Injury
NCCIH(PI):Optimizing Interventions to Reverse Stress Effects on the Aging Brain
NCATS(Significant Contributor):A Mechanistic Approach to Optimize MBSR for Tinnitus
Patient-Centered Outcomes Research Institute(PI):Optimizing Outcomes in Treatment-Resistant Depression in Older Adults
NCATS(Significant Contributor):The NCATS Clinical Trial Mobile Suite
NIAMSD(Significant Contributor):Molecular Transducers of Physical Activity Adult Clinical Center
NCCIH(Significant Contributor):Neural Mechanisms of Mindfulness: A Discordant Twin Design
ICTS(PI):High Dose Ketamine for Treatment Resistant Depression in Older Adolescents
NIDCD(Significant Contributor):Relieving the Emotional Stress of Tinnitus and Improving Attentional Focus Trial
NIH(Key Personnel):Mindfulness-Based Stress Reduction on Insomnia for Adults with Chronic Pain due to Rheumatoid Arthritis
NCATS(Significant Contributor):Fully-Remote Clinical Trial of Exercise in Older Adults: Focus on Rigor and Reproducibility
NCATS(Significant Contributor):Washington University Institute of Clinical and Translational Sciences: Network Capacity – Liaison to Trial Innovation Centers
NIMH(Significant Contributor):5/5 Neurocognitive and neuroimaging biomarkers: predicting progression toward dementia in patients with treatment resistant late-life depression