Return to the Faculty List

Scott Saccone, PhD

Current Position
Associate Professor of Psychiatry

Areas of Research Interests
I am interested in statistical genetics and bioinformatics. I am currently working on methods of integrating genomic databases into the design, analysis and interpretation of SNP association studies of human disease. While these methods are general and can be applied to any disease, I am primarily interested in nicotine dependence, alcoholism and other addiction related phenotypes.

Key Publications
Saccone SF, Quan J, Mehta G, Bolze R, Thomas P, Deelman E, Tischfield JA, Rice JP (2011 Jan). New tools and methods for direct programmatic access to the dbSNP relational database. Nucleic Acids Res. 39(Database issue): D901-7.  Full Article ->

Agrawal A, Lynskey MT, Hinrichs A, Grucza R, Saccone SF, Krueger R, Neuman R, Howells W, Fisher S, Fox L, Cloninger R, Dick DM, Doheny KF, Edenberg HJ, Goate AM, Hesselbrock V, Johnson E, Kramer J, Kuperman S, Nurnberger Jr JI, Pugh E, Schuckit M, Tischfield J, The GENEVA Consortium, Rice JP, Bucholz KK, Bierut LJ (2011 Jul). A genome-wide association study of DSM-IV cannabis dependence. Addict Biol. 16(3): 514-518.  Full Article ->

Pergadia ML, Glowinski AL, Wray NR, Agrawal A, Saccone SF, Loukola A, Broms U, Korhonen T, Penninx BW, Grant JD, Nelson EC, Henders AK, Schrage AJ, Chou YL, Keskitalo-Vuokko K, Zhu Q, Gordon SD, Vink JM, de Geus EJ, Macgregor S, Liu JZ, Willemsen G, Medland SE, Boomsma DI, Montgomery GW, Rice JP, Goate AM, Heath AC, Kaprio J, Martin NG, Madden PA (2011 May 15). A 3p26-3p25 Genetic Linkage Finding for DSM-IV Major Depression in Heavy Smoking Families. Am J Psychiatry.   Full Article ->

Saccone SF, Bolze R, Thomas P, Quan J, Mehta G, Deelman E, Tischfield JA, Rice JP (2010 Jul). SPOT: a web-based tool for using biological databases to prioritize SNPs after a genome-wide association study. Nucleic Acids Res. 38(Web Server issue): W201-9.  Full Article ->

McEachin RC, Chen H, Sartor MA, Saccone SF, Keller BJ, Prossin AR, Cavalcoli JD, McInnis MG (2010 Nov 19). A genetic network model of cellular responses to lithium treatment and cocaine abuse in bipolar disorder. BMC Syst Biol. 4158.  Full Article ->

Knight J, Rochberg NS, Saccone SF, Nurnberger JI Jr, NIMH Genetics Initiative Bipolar Disorder Consortium, Rice JP (2010 Oct 5). An investigation of candidate regions for association with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 153B(7): 1292-7.  Full Article ->

Funded Research Projects
NIDA (PI): Design and Interpretation of SNP Association Studies of Addiction
ACS (PI): Identifying Genetic Risk Loci for Nicotine Dependence
NCI (Key Personnel): The Collaborative Genetic Study of Nicotine Dependence
NIMH (Key Personnel): NIMH Center for Collaborative Genetic Studies - Data Analysis
NIDA (Key Personnel): The Genetics of Vulnerability to Nicotine Addictions
NIAAA (SUNY)(Key Personnel): Collaborative Study on the Genetics of Alcoholism
NIDA (Key Personnel): Case Control Candidate Gene Study of Addiction
NIDA (Key Personnel): NIDA Center for Genetic Studies