John Pruett, Jr., MD, PhD
Associate Professor of Psychiatry, Radiology, and Psychological & Brain Sciences
-Member, The Division of Biology and Biomedical Sciences (DBBS), Neuroscience Section
Education and Training
-BA: Princeton University, Princeton, New Jersey, 1990
-Medical Degree: Washington University School of Medicine, St. Louis, Missouri, 2000
-Residency: Washington University School of Medicine, St. Louis, Missouri, 2003
-Fellowship: Child and Adolescent Psychiatry, Washington University School of Medicine, St. Louis, Missouri, 2005
-Postdoctoral Research Scholar/Instructor: Psychiatry, Washington University School of Medicine, St. Louis, Missouri, 7/1/05-11/30/07
-Instructor of Psychiatry Department of Psychiatry Division of Child and Adolescent Psychiatry, Washington University School of Medicine, St. Louis, MO 12/01/07-6/30/08
-Assistant Professor of Psychiatry (Child), Washington University School of Medicine, St. Louis, MO 7/01/08-6/30/14
-Associate Professor of Psychiatry (Child) and Radiology, Washington University School of Medicine, St. Louis, MO 7/01/14-current
-Associate Professor of Psychiatry (Child), Radiology, and Psychology and Brain Sciences, Washington University School of Medicine, St. Louis, MO 12/28/15-current.
-Back-Up Chair, NIH Developmental Brain Disorders (DBD) Study Section, 2017
-Chartered Member, NIH Developmental Brain Disorders (DBD) Study Section, 2015
-Board Member, Missouri Families for Effective Autism Treatment (MO-FEAT), 2010
-Promoted to full membership in Sigma Xi, The Scientific Research Society, 2009
-Awarded AACAP Program Committee Junior Faculty Travel Scholarship to attend the American Academy of Child and Adolescent Psychiatry Annual Meeting, October 27-November 1, 2009
-Awarded Position at the 9th Annual Future Leaders in Psychiatry Meeting Emory University School of Medicine, Atlanta GA, May 2007.
-The Eli Robins Award, for Excellence in Clinical Psychiatry, in Teaching and Research, Washington University School of Medicine, Department of Psychiatry, 2003
-Elected to membership: The Alpha Omega Alpha, Honor Medicial Society, 2003
-NIMH Outstanding Resident Award winner, 2002
-Letter of commendation from Washington University School of Medicine Committee on Academic Evaluation of Students for outstanding performance during the 1998-1999 academic year, 1999
-Finalist: The 22nd Annual James L. O'Leary Prizes for Research in Neuroscience. Washington University School of Medicine, Department of Anatomy and Neurobiology, 1999
-Awarded position: The James S. McDonnell Foundation Summer Institute in Cognitive Neuroscience at University of California, Davis, 1995
-Graduated with honors: Department of Biology, Princeton Universtiy, concentration in neurophysiology, 1990
-Elected to membership in Sigma Xi, The Scientific Research Society, 1990
-The Charles M. Cannon Memmorial Prize for presentation of senior thesis work, Princeton University, 1990
Areas of Clinical Interest
-Autism, general child and adolescent psychiatry, pediatric epilepsy patients
Areas of Research Interests
-The neuroscience of autism and related disorders, social cognition and comparative cognition
Shaw JA, Bryant LK, Malle BF, Povinelli DJ, Pruett JR, (2017 Apr). The relationship between joint attention and theory of mind in neurotypical adults. Conscious Cogn. 51: 268-278. Full Article ->
Eggebrecht AT, Elison JT, Feczko E, Todorov A, Wolff JJ, Kandala S, Adams CM, Snyder AZ, Lewis JD, Estes AM, Zwaigenbaum L, Botteron KN, McKinstry RC, Constantino JN, Evans A, Hazlett HC, Dager S, Paterson SJ, Schultz RT, Styner MA, Gerig G, Das S, Kostopoulos P, Schlaggar BL, Petersen SE, Piven J, Pruett JR, , (2017 Mar). Joint Attention and Brain Functional Connectivity in Infants and Toddlers. Cereb. Cortex. 27(3): 1709-1720. Full Article ->
Pruett JR, Kandala S, Hoertel S, Snyder AZ, Elison JT, Nishino T, Feczko E, Dosenbach NU, Nardos B, Power JD, Adeyemo B, Botteron KN, McKinstry RC, Evans AC, Hazlett HC, Dager SR, Paterson S, Schultz RT, Collins DL, Fonov VS, Styner M, Gerig G, Das S, Kostopoulos P, Constantino JN, Estes AM, , Petersen SE, Schlaggar BL, Piven J, (2015 Apr). Accurate age classification of 6 and 12 month-old infants based on resting-state functional connectivity magnetic resonance imaging data. Dev Cogn Neurosci. 12: 123-33. Full Article ->
Pruett JR, Hoertel S, Constantino JN, Moll AL, McVey K, Squire E, Feczko E, Povinelli DJ, Petersen SE, (2013 March). Impaired eye region search accuracy in children with autistic spectrum disorders. PLoS ONE. 8(3): e58167. Full Article ->
Feczko E, Miezin FM, Constantino JN, Schlaggar BL, Petersen SE, Pruett JR, (2012 Oct). The hemodynamic response in children with Simplex Autism. Dev Cogn Neurosci. 2(4): 396-408. Full Article ->
Pruett JR, Kandala S, Petersen SE, Povinelli DJ, (2015 Jul). Brief Report: Theory of Mind, Relational Reasoning, and Social Responsiveness in Children With and Without Autism: Demonstration of Feasibility for a Larger-Scale Study. J Autism Dev Disord. 45(7): 2243-51. Full Article ->
Funded Research Projects
R01 MH093510 (NIMH) (Pruett, PI) 4/17/12-1/31/18
"fcMRI in Infants at High Risk for Autism"
This study will test the altered brain functional connectivity hypothesis of autism during infancy.
R01 HD055741 (NICHD) (Piven, PI) 9/4/12-5/31/17
“A Longitudinal MRI Study of Infants at Risk for Autism” (fcMRI Imaging Processing Core)
This study is a competing continuation of an Autism Center of Excellence (ACE) Network grant supporting a prospective, longitudinal examination of brain and behavior at 6, 12 and 24 months in infants at high familial risk (HR) for autism.
Role: (fcMRI Imaging Processing Core) Sub-Contract PI
1 U54 HD087011-01 (NICHD) (Constantino and Schlaggar, Co-PIs) 9/18/15 – 5/31/20
“Sex-Specific Modulation of ASD Liability: Compensatory Mechanisms and Recurrence”
The Intellectual and Developmental Disabilities Research Center at the Washington University School of Medicine is a scientific program composed of three core facilities, one dedicated to studies of cellular and molecular mechanisms of causation in IDD, one dedicated to the identification of “signatures” of developmental disability that can be imaged in the developing brain, and one dedicated to in-depth clinical assessment of human subjects and the translation of new understanding of causal mechanisms into higher impact intervention.
WUIDDRC Pilot Fund (Pruett, PI) 5/27/16 – 5/26/17
“Toddler social motivation and communication”
The scientific objective of this study is to correlate dimensional measures of joint attention with ASD-relevant abilities.
The Drs. John R. (Sr.) and Patricia O. Pruett Fund for research in social cognition and for undergraduate training
The Azrieli Neurodevelopmental Research Program/ Brain Canada Multi-Investigator Research Initiative (A. Evans, PI) 4/1/14-3/31/19 "Structural and Functional Networks in Autism Spectrum Disorder and Fragile X Syndrome"
R01 MH104543 (NIMH) (L. Parr, PI)
"Effects of Oxytocin on Brain, Behavior, and Development" 5/1/15-4/30/20.
This project will examine the effects of repeated oxytocin administration on social behavior and neural development in infant monkeys as a first step towards understanding how this hormone modulates social behavior.