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John Pruett, Jr., MD, PhD

Current Position
Associate Professor of Psychiatry, Radiology, and Psychological & Brain Sciences

University Roles
-Member, The Division of Biology and Biomedical Sciences (DBBS), Neuroscience Section

Education and Training
-BA: Princeton University, Princeton, New Jersey, 1990
-Medical Degree: Washington University School of Medicine, St. Louis, Missouri, 2000
-Residency: Washington University School of Medicine, St. Louis, Missouri, 2003
-Fellowship: Child and Adolescent Psychiatry, Washington University School of Medicine, St. Louis, Missouri, 2005
-Postdoctoral Research Scholar/Instructor: Psychiatry, Washington University School of Medicine, St. Louis, Missouri, 7/1/05-11/30/07
-Instructor of Psychiatry Department of Psychiatry Division of Child and Adolescent Psychiatry, Washington University School of Medicine, St. Louis, MO 12/01/07-6/30/08
-Assistant Professor of Psychiatry (Child), Washington University School of Medicine, St. Louis, MO 7/01/08-6/30/14
-Associate Professor of Psychiatry (Child) and Radiology, Washington University School of Medicine, St. Louis, MO 7/01/14-current
-Associate Professor of Psychiatry (Child), Radiology, and Psychology and Brain Sciences, Washington University School of Medicine, St. Louis, MO 12/28/15-current.

Major Awards
-Chartered Member, NIH Developmental Brain Disorders (DBD) Study Section, 2015
-Board Member, Missouri Families for Effective Autism Treatment (MO-FEAT), 2010
-Promoted to full membership in Sigma Xi, The Scientific Research Society, 2009
-Awarded AACAP Program Committee Junior Faculty Travel Scholarship to attend the American Academy of Child and Adolescent Psychiatry Annual Meeting, October 27-November 1, 2009
-Awarded Position at the 9th Annual Future Leaders in Psychiatry Meeting Emory University School of Medicine, Atlanta GA, May 2007.
-The Eli Robins Award, for Excellence in Clinical Psychiatry, in Teaching and Research, Washington University School of Medicine, Department of Psychiatry, 2003
-Elected to membership: The Alpha Omega Alpha, Honor Medicial Society, 2003
-NIMH Outstanding Resident Award winner, 2002
-Letter of commendation from Washington University School of Medicine Committee on Academic Evaluation of Students for outstanding performance during the 1998-1999 academic year, 1999
-Finalist: The 22nd Annual James L. O'Leary Prizes for Research in Neuroscience. Washington University School of Medicine, Department of Anatomy and Neurobiology, 1999
-Awarded position: The James S. McDonnell Foundation Summer Institute in Cognitive Neuroscience at University of California, Davis, 1995
-Graduated with honors: Department of Biology, Princeton Universtiy, concentration in neurophysiology, 1990
-Elected to membership in Sigma Xi, The Scientific Research Society, 1990
-The Charles M. Cannon Memmorial Prize for presentation of senior thesis work, Princeton University, 1990

Areas of Clinical Interest
-Autism, general child and adolescent psychiatry, pediatric epilepsy patients


Areas of Research Interests
-The neuroscience of autism and related disorders, social cognition and comparative cognition

More articles and abstracts at the National Library of Medicine

Key Publications
Lewis JD, Evans AC, Pruett JR, Botteron K, Zwaigenbaum L, Estes A, Gerig G, Collins L, Kostopoulos P, McKinstry R, Dager S, Paterson S, Schultz RT, Styner M, Hazlett H, Piven J (2014 May 6). Network inefficiencies in autism spectrum disorder at 24 months. Transl Psychiatry. 4e388.  Full Article ->

Feczko Eric J,Bliss-Moreau Eliza,Walum Hasse,Pruett John R,Parr Lisa A,The Macaque Social Responsiveness Scale (mSRS): A Rapid Screening Tool for Assessing Variability in the Social Responsiveness of Rhesus Monkeys (Macaca mulatta).2016 Jan 05;11:e0145956;  Full Article ->

Pruett JR Jr, Kandala S, Hoertel S, Snyder AZ, Elison JT, Nishino T, Feczko E, Dosenbach NU, Nardos B, Power JD, Adeyemo B, Botteron KN, McKinstry RC, Evans AC, Hazlett HC, Dager SR, Paterson S, Schultz RT, Collins DL, Fonov VS, Styner M, Gerig G, Das S, Kostopoulos P, Constantino JN, Estes AM, IBIS Network, Petersen SE, Schlaggar BL, Piven J (2015 Apr). Accurate age classification of 6 and 12 month-old infants based on resting-state functional connectivity magnetic resonance imaging data. Dev Cogn Neurosci. 12123-33.  Full Article ->

Elison JT, Wolff JJ, Reznick JS, Botteron KN, Estes AM, Gu H, Hazlett HC, Meadows AJ, Paterson SJ, Zwaigenbaum L, Piven J, Infant Brain Imaging Study (IBIS) Network (2014 Nov). Repetitive behavior in 12-month-olds later classified with autism spectrum disorder. J Am Acad Child Adolesc Psychiatry. 53(11): 1216-24.  Full Article ->

Pruett JR Jr, Kandala S, Petersen SE, Povinelli DJ (2015 Jan 29). Brief Report: Theory of Mind, Relational Reasoning, and Social Responsiveness in Children With and Without Autism: Demonstration of Feasibility for a Larger-Scale Study. J Autism Dev Disord.   Full Article ->

Faughn C, Marrus N, Shuman J, Ross SR, Constantino JN, Pruett JR Jr, Povinelli DJ (2015 May). Brief Report: Chimpanzee Social Responsiveness Scale (CSRS) Detects Individual Variation in Social Responsiveness for Captive Chimpanzees. J Autism Dev Disord. 45(5): 1483-8.  Full Article ->

Funded Research Projects

R01 MH093510 (NIMH) (Pruett, PI) 4/17/12-1/31/17
“fcMRI in Infants at High Risk for Autism”
This study will test the altered brain functional connectivity hypothesis of autism during infancy.
Role: PI

R01 HD055741 (NICHD) (Piven, PI) 9/4/12-5/31/17
“A Longitudinal MRI Study of Infants at Risk for Autism” (fcMRI Imaging Processing Core)
This study is a competing continuation of an Autism Center of Excellence (ACE) Network grant supporting a prospective, longitudinal examination of brain and behavior at 6, 12 and 24 months in infants at high familial risk (HR) for autism.
Role: (fcMRI Imaging Processing Core) Sub-Contract PI

McDonnell Center for Systems Neuroscience

The Drs. John R. (Sr.) and Patricia O. Pruett Fund for research in Theory of Mind and for undergraduate training

The Azrieli Neurodevelopmental Research Program/ Brain Canada Multi-Investigator Research Initiative (A. Evans, PI) 4/1/14-3/31/19 "Structural and Functional Networks in Autism Spectrum Disorder and Fragile X Syndrome"
Role: Mentor/Collaborator

R01 MH104543 (NIMH) (L. Parr, PI)
"Effects of Oxytocin on Brain, Behavior, and Development" 5/1/15-4/30/20.
This project will examine the effects of repeated oxytocin administration on social behavior and neural development in infant monkeys as a first step towards understanding how this hormone modulates social behavior.
Role: Consultant